About My Journal Publications

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About My
Journal Publications

• By
• ADEBAYO, A.H.
• DEPARTMENT OF BIOLOGICAL SCIENCES (BIOCHEMISTRY
  UNIT)
• COVENANT UNIVERSITY, OTA.

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RESEARCH INTERESTS

• BIOCHEMICAL/CLINICAL TOXICOLOGY
• ETHNOPHARMACOLOGY
• (MEDICINAL PLANT TOXICOLOGY)

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MOTIVATION INTO MEDICINAL PLANT RESEARCH

• Two Incidences stimulated my interest into
  medicinal plant research.
• 1. The Port Harcourt Incidence In 1999, 10
  people died after receiving medication from
  Traditional Herbal Practitioners.
• 2. The Calabar Incidence In 2000, 7 people
  died after being treated for Diabetes Mellitus
  with Medicinal plants.

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IMPLICATIONS

• Some Medicinal Plants contain active substances
  which may be toxic to the body.
• There is also the need to determine suitable
  therapeutic dosage of any plant that will be used
  for medicinal purposes.
• These and many other reasons stimulated my
  interest in Medicinal plant Research.

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PUBLISHED JOURNAL ARTICLES

• 1.The Effects of Ethanolic Leaf Extract of
  Commiphora africana (Burseraceae) on Lipid
  Profile in Rats. International Journal of
  Pharmacology 20062 (6) 618-622.
• 2. Anti Ulcer Activity of the Aqueous Leaf
  Extract of Ficus thonningii Moraceae (Chinese
  Banyan). Journal of Medicine in the Tropics 2006
  8 (1) 27-32.

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Papers In Press

• The Effects of Ethanolic Leaf Extract of
  Commiphora africana (Burseraceae) on Rat Liver
  and Kidney Functions. Journal of Pharmacology and
  Toxicology 2007 (Academic Journal Inc., USA).
• Article is accessible online http//198.170.104.1
  38/jpt/0/100-JPT.pdf

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• Some Lysosomal Enzyme Profiles in Children with
  Nephroblastoma The Effect of Nephrectomy. Trends
  in Medical Research (Academic Journal Inc. USA).
  Article is accessible online
• http//198.170.104.138/tmr/0/31TMR.pdf

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Summary of Work.

• Two of the papers were generated from my MSc.
  Thesis.
• The title of my first paper is The Effects of
  Ethanolic Leaf Extract of Commiphora africana
  (Burseraceae) on Lipid Profile in Rats.

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Commiphora africana

• Commiphora africana is a medicinal plant and
  belongs to
• Family Burseraceae
• Group Myrrh
• It is used by traditional healers for the
  treatment of
• Wounds
• Menstrual pain
• Painful Swelling
• Typhoid Fever

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Local Names of the Plant

• In Hausa, it is called, Dashi
• The Fulanis called it, Badadi and,
• The Kanuris called it, Kabi.
• The plant is not common in the southern part of
  the country.

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Effects of Leaf Extract of Commiphora africana
on Lipid Profile in Rats

• Aim To determine the effects of ethanolic Leaf
  extract of Commiphora africana on some Lipid
  profiles (Total Cholesterol, TG, HDL-Cholesterol
  and LDL-Cholesterol) in Rats.

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Justification of Study

• Insufficient information with regards to the
  effects of Commiphora africana on Lipid profiles
  and
• The search for suitable medicinal plants among
  the Commiphora species against the high incidence
  of cardiovascular disorders becomes imperative.

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Experimentation

• Study was conducted on experimental rats (albino
  wistar rats) by administering graded doses of the
  leaf extract intraperitoneally for a period of 10
  days.
• Both acute and sub-acute studies were conducted.
• The rats were anaesthetized with ether and the
  blood taken for Cholesterol, TG, HDL and LDL
  Cholesterol analyses.

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Results

• Showed significant decrease in
• Total Cholesterol (plt0.05),
• Triglycerides (plt0.01), and
• LDL- Cholesterol (plt0.05)
• Significantly increased
• HDL-Cholesterol (plt0.01).
• in Serum samples.

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Conclusion

• Commiphora africana contains antilipidemic
  properties and therefore may be used for the
  treatment of cardiovascular disorders and other
  related disorders within the safety limit.
• For further details, access on-line on
• ansijournals.com/ijp/2006/618-622.pdf

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Effects of Leaf Extract of Commiphora africana
on Rat Liver and Kidney Functions

• Aim of the Study To determine the toxicological
  risk of the consumption of the plant as
  antimicrobial and antilipidemic agents by
• Measuring biochemical markers of liver and kidney
  functions in the rats sera.
• Extracting the liver and kidney for
  histopathological assessment.

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Justification of Study

• Commiphora africana is widely used in the
  northern part of Nigeria by the traditional
  Medicine Practitioner for the treatment of
  typhoid fever and other ailments.
• Absence of relevant information on the safety of
  the plant through appropriate biochemical
  parameters necessitated this research.

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Experimentation

• Study was conducted on experimental rats by
  intraperitoneally administering graded doses of
  the extract for a period of 10 days.
• Both acute and sub-acute studies were conducted.
• Blood samples were then taken from rats after
  anaesthesia in ether for LFTs and Kidney function
  test.
• The rats livers and kidneys were removed for
  histopathological studies.

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Results of Study

• Results showed no damage to the liver and kidney
  at lower conc. (lt100mg/ml). but at higher conc.,
  the kidney was damaged (i.e. glomerulonephritis
  and proliferation of mesanger cells).

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Recommendation

• The Commiphora africana may therefore be used as
  antimicrobial and antilipidemic agents within the
  acceptable limit of safety.
• For further details, access it on- line
• http//198.170.104.138/jpt/0/100-JPT.pdf

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The Place of Covenant University

• CU provided conducive environment (i.e. Serene
  and 24 Hrs electricity and water supply).
• All publications were done via the internet
  facilities of the School at no cost.
• The research base of CU is being projected.
• The God Factor.

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On-Line Journal Publication

• The following websites will be useful for sending
  your articles for publication
• academicjournals.net (USA Publication cost is
  Free).
• ansijournals.com (Pakistan Publication cost is
  100 per Publication)

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Appreciation

• God, who gave me the ability to write these
  papers.
• Chancellor, for his motivation and inspiration.
• Vice-Chancellor for her high level of humility
  and good leadership.
• Registrar, for all his kind gestures.
• HOD, for his good leadership qualities and
  insisted that management must know.

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• THANK YOU FOR LISTENING!!!