Drugs from the Sea: Bioactive Compounds from Marine and Freshwater Sources

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Drugs from the Sea Bioactive Compounds from
Marine and Freshwater Sources (CHM 5306 Special
Topics in Biological Chemistry) Fall 2006
Dr. John P. Berry Tel. [phone] E-mail
John.Berry_at_fiu.edu Office CP 346 (W, F), Marine
Sci. 354/332 Office Hours W 315-515 (CP 346),
or by appointment Credits 3 Time/Day Fridays,
800 am to 1040 am Location CP 107
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Overview

• Oceans Are Diverse Habitats (e.g. coral reefs)
• Oceans Diversity Mediated by Chemistry (i.e.
  biologically active compounds)
• Diversity of Compounds from Marine Animals are
  Rich Source of Drugs

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Ocean Habitats are Diverse
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Freshwater Habitats
Lakes and Ponds Rivers and Streams
Wetlands Swamps, Bogs, Fens, etc.
also estuarine (i.e. brackish) habitats!
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Coral Reefs
23.5 N
23.5 S
255,330 sq. km. lt 0.25 of the area of the ocean
Coral Reefs 50 m deep (ocean is 3.8 km deep)
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Coral reefs are among the most complex habitats
on Earth
25 of oceans fish
1 million species identified
estimated 8 million to go!
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Why are coral reefs so complex?
Shore
Deep Water
Colonization
High oxygen
Architecture
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Many of the interactions in the coral reef are
based on CHEMISTRY
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Biologically Active Compounds
Toxins (Toxicology)
Drugs (Pharmacology)
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Drugs from the Sea Marine Animals
Percent Compounds Tested by NCI with Significant
Cytotoxicity
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Vast Majority of Drugs from Marine Invertebrates
Microorganisms
Green Algae
Sponges
Brown Algae
Red Algae
Tunicates
Echinoderms
Mollusca
Cnidarians (e.g. Corals)
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Why so many biologically active compounds from
invertebrates?