Outline of Bioinorganic Chemistry

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Outline of Bioinorganic Chemistry

• Chapter 1 Introduction
• Chapter 2 Alkali and Alkaline Earth Metals
• Chapter 3 Metalloproteins and Metalloenzymes
• Chapter 4 Bioinorganic Chemistry of Nonmetallic
  
• Inorganic Compounds
• Chapter 5 The Frontiers of Bioinorganic
• Chemistry

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Chapter 1 Introduction

• 1. What is Bioinorganic Chemistry?
• 2. Inorganic Elements in Biological Systems
• 3. Biological Ligands (Biologically Important
  Compounds)
• 4. Experimental Methods (Physicochemical Methods
  and Biological Methods)

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1.1 What is Bioinorganic Chemistry?

• 1.1.1 Bioinorganic Chemistry is a leading
  discipline at the interface of chemistry and
  biology
• Many critical processes require metal ions,
  including respiration, much of metabolism,
  nitrogen fixation, photosynthesis, development,
  nerve transmission, muscle contraction, signal
  transduction, and protection against toxic and
  mutagenic agents.
• Synthetic Chemists, Spectroscopists,
  Electrochemists, Theoreticians, Biochemists, and
  molecular Biologists meet at the frontiers of
  chemistry and biology and are challenged by
  exciting problems.

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1.1.2 Development of Bioinorganic Chemistry

• Molecule, Cell, and Humanity
• elements small molecules amino
  acids,
• nucleotides,carbohydrates, fatty acids
  
• protein(enzymes), lipids,
  poly-carbohydrates
• poly-nucleotides metalloproteins
• (metalloenzymes), other macromolecules
• procaryocyte, eucaryocyte
  bacteria,
• microorganisms, plants, animals, humanity

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The first symposium on bioinorganic chemistry was
initiated by inorganic chemists in 1970 The
first book called Bioinorganic Chemistry was
written by 45 authors and published in 1973
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1.1.3 Current Situation

• Inorganic Biochemistry An Introduction
• James A. Cowan
• The Ohio State University 1993,
  1997
• Principles of Bioinorganic Chemistry
• Stephen J. Lippard
• Maqssachusett Institute of
  Technology
• Jeremy M. Berg
• John Hopkins School of Medicine

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The International Conference on Biological
Inorganic Chemistry

• 1983 in Florence, Italy
• 1985 in the Algarve, Portugal
• 1987 in Noordwijkerhout, The Netherlands
• 1989 in Cambridge, USA
• 1991 in Oxford, UK
• 1993 in La Jolla, USA
• 1995 in Lubeck, Germany
• 1997 in Yokohama, Japan
• 1999 in Minneapolis, Minnestoa

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5th International Symposium on Applied
Bioinorganic Chemistry

• Metalloenzymes - Model Compounds
• Biomaterials Bioelectronics
• Metal Based Drugs Metals in Medicine
• Metals Toxicology and Metals in the Environment
• Metal Interaction with DNA and RNA Constituents
• Spectroscopic Applications

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• J. Am. Chem. Soc
• Biochemistry
• Chem. Rev
• Acc. Chem. Res.
• Annual Reports on the Progress of Chemistry
• Nature
• Science
• J. Inorg. Biochem

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1.2 Inorganic Elements in Biological Systems

• Bulk Elements O, C, H, N, Ca, S, P,
• Na, K, Cl, Mg, etc.
• Trace Elements Mo, Mn, Fe, Co, Cu,
• Zn, I, Si, etc.
• Ultra-trace Elements V, Cr, Se, Br, Sn,
• F, etc.

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1.3 Biological Ligands

• Proteins, Carbohydrates, Lipid, Steroids,
  Nucleotides
• Prosthetic Groups
• Coenzyme B12
• Bleomycin and Siderophores
• Complex Assembies

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1.4 Methodology

• Physicochemical Methods
• Biological Methods
• Native, Modification, Mimesis
• Structure--Property--Function--Reaction
• Structure--PropertyActivity--Relationship