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IOL Chemicals and Pharmaceuticals Limited

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IOL Chemicals and Pharmaceuticals Limited Product Range Active Pharmaceutical Ingredients Ibuprofen Proton Pump Inhibitors (PPI s) (Proposed) Capacity By ... – PowerPoint PPT presentation

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Title: IOL Chemicals and Pharmaceuticals Limited


1
IOL Chemicals and Pharmaceuticals Limited
2
Geographical Location Map
3
Mile Stones Crossed
  • 1986 IOLCP Established
  • 1991 Commenced Acetic Acid Production
  • 1996 Commissioned Ethyl Acetate Plant
  • 1999 Commenced Acetic Anhydride Production
  • 2000 Commissioned Ibuprofen Plant
  • 2006 Commissioned Power Cogeneration

4
Product Range
  • Active Pharmaceutical Ingredients
  • Ibuprofen
  • Proton Pump Inhibitors (PPIs) (Proposed)

Chemical Products Acetic Acid
Ethyl Acetate
Acetic Anhydride MCA Acetyl
Chloride IBB
5
Capacity By Product
Capacity ( TPA )
Acetic Acid
Ethyl Acetate
Acetic Anhydride
Ibuprofen
Products
6
Revenues
USD 48 mln
USD 36 mln
USD 20 mln
USD 75 mln
USD 70 mln

Years
7
Operating Profit
USD 1.8 mln
USD 7.7 mln
USD 3.9 mln
USD 3.8mln
USD 7.2 mln
Years
8
Net Profit After Tax
USD 0.53 mln
USD 2.57 mln
USD 1.57 mln
USD 1.51 mln
USD 2.64 mln
Years
9
Revenue Distribution By Product ()
Products
10
Export Sales
USD 0.41 mln
USD 10.4 min
USD 4.79 min
USD 2.70mln
USD 9.16mln
Years
11
GROWTH - Projects Under Implementation
  • Recently increased Ibuprofen capacity from 1800
    TPA to 3600 TPA .
  • Currently implementing projects for Capacity
    Expansions, Forward Backward Integration
    Power Cogeneration, involving a capital
    expenditure of Rs 256 Crores (approx USD 53.3
    million).
  • Commencing a new project for the production of
    PPIs i.e. Rabiprazole, Omeprazole, Pantoprazole
    Esomeprazole and Lansoprazole in Jan 2010 at a
    cost of Rs 100 Crores ( approx USD 20.83 million).

12
Under Implementation Projects Contd
Product UOM Existing Capacities Proposed Capacities Expected Completion Date
Capacity Enhancement      
Acetic Acid TPA 50000 75000 Nov,2009
Acetic Anhydride TPA 12000 18000 Nov,2009
Ethyl Acetate TPA 33000 36000 Nov,2009
Ibuprofen TPA 3600 6000 Dec., 2009
Cogeneration MW 4 17 Nov,2009
Backward Integration      
Iso Butyl Benzene (Used as RM For Ibuprofen) TPA - 6600 Nov,2009
Forward Integration      
Monochloroacetic Acid Acetyl Chloride Acetic Anhydride as RM End use in Ibuprofen TPA - 7200 Nov,2009
Monochloroacetic Acid Acetyl Chloride Acetic Anhydride as RM End use in Ibuprofen TPA - 5200 Nov,2009
Upcoming Projects
PPIs TPA - 480 March , 2011
13
Co-generation
Expanding captive power cogeneration
capacity to 17 MW, from 4 MW currently
Present captive energy generation include Steam
and Power Generation
14
Monochloroacetic Acid Acetyl ChlorideProcess
Flow
Acetic Anhydride
Acetic Acid
HCl
Acetic Acid (By Product)
Chlorine Gas
HCl (By Product)
Acetyl Chloride
MCA
15
Uses of Iso-Butyl Benzene
IBB PLANT
SPENT GAS
IBB
HIGH HYDRO CARBON
LOW HYDRO CARBON
POTASIUM CARBONATE
THERMO PACK
ACETIC ANHY DRIDE
MARKET
CAPTIVE CONSUMP TION
CO- GEN
ACETIC ANHY DRIDE
ACETIC ANHY DRIDE
MARKET
THERMO PACK
MARKET
THE END PACK
REUSE IN IBB PROCESS
CO- GEN
16
Projected Capacity Fiscal Year 2011-12
Product UOM Then Capacities Potential Capacities
Capacity Enhancement      
Acetic Anhydride TPA 18000 33000
Ethyl Acetate TPA 36000 50000
Ibuprofen TPA 6000 8000
Iso Butyl Benzene TPA 6600 10000
Monochloroacetic Acid TPA  7200  10000 
Acetyl chloride TPA 5200 8000
ALL OF THESE PROJECTS WILL HAVE TO BE FINANCED
FROM INTERNAL ACCRUALS AND TERM DEBT WITHOUT
FURTHER DILUTION IN EQUITY. THIS WILL RESULT IN
SIGNIFICANT GROWTH IN PROFITABILITY AND EARNINGS
PER SHARE
17
Global Market Presence
The various international markets catered till
date include 1.BANGLADESH 15.IRAN
29.SPAIN
43.ITALY 2.EGYPT 16.VEITNAM
30.PHILIPPINES 44.MAURITIUS 3.UGANDA
17.KUWAIT 31.CHILE
45.CHILE 4.SYRIA 18.GERMAN
32.ZIMBABWE 46.TAIWAN
5.AUSTRALIA 19.COLOMBIA
33.URUGUAY 47.TASMANIA 6.DUBAI
20.SINGAPORE 34.GHANA
48.OMAN 7.PAKISTAN 21.HONG
KONG 35.TURKEY
49.COLOMBIA 8.THAILAND 22.MALAWI
36.CHINA 50.SOUTH
AMERICA 9.MALAYSIA 23.BRAZIL
37.CONGO 51.YEMEN
10.BOLIVIA 24.SOUTH KOREA
38.SUDAN 11.MEXICO 25.PERU
39.NIGERIA 12.VENEZUELA
26.GUATEMALA 40.KENYA 13.ALGERIA
27.NEPAL 41.NEW ZEALAND
14.LATAVIA 28.DENMARK
42.SRI LANKA
18
Our Products - Our Pride
19
Ibuprofen
  • Non-Steroidal Anti Inflammatory Drug (NSAID)
  • Reduces Hormones Causing Inflammation Pain in
    Body
  • Usage in Treatment of Variety of Ailments
  • Grades Available
  • - IP / BP /USP / EP /JP
  • - Micronized
  • - Dexibuprofen
  • - DC ( Directly
    compressible )

20
Applications End Usage - Ibuprofen
Application End Use User
Pharma Industry as an NSAID ( Non- steroidal Anti - inflammatory Drug ) Inflammation Aristo Pharmaceuticals Ltd
Pharma Industry as an NSAID ( Non- steroidal Anti - inflammatory Drug ) Acute / Chronic Pains Sri Krishna Pharmaceuticals Ltd
Pharma Industry as an NSAID ( Non- steroidal Anti - inflammatory Drug ) Rheumatoid Pain Tablets India Limited
Pharma Industry as an NSAID ( Non- steroidal Anti - inflammatory Drug ) Primary Dysmenorrhea Indoco Remedies Limited
Pharma Industry as an NSAID ( Non- steroidal Anti - inflammatory Drug ) Post Operative Pain Fourrts Lab Limited
Pharma Industry as an NSAID ( Non- steroidal Anti - inflammatory Drug ) Fever Strides Arcolabs ltd
Application End Use User
Pharma Industry as an NSAID ( Non- steroidal Anti - inflammatory Drug ) Inflammation Aristo Pharmaceuticals Ltd
Pharma Industry as an NSAID ( Non- steroidal Anti - inflammatory Drug ) Acute / Chronic Pains Sri Krishna Pharmaceuticals Ltd
Pharma Industry as an NSAID ( Non- steroidal Anti - inflammatory Drug ) Rheumatoid Pain Tablets India Limited
Pharma Industry as an NSAID ( Non- steroidal Anti - inflammatory Drug ) Primary Dysmenorrhea Indoco Remedies Limited
Pharma Industry as an NSAID ( Non- steroidal Anti - inflammatory Drug ) Post Operative Pain Fourrts Lab Limited
Pharma Industry as an NSAID ( Non- steroidal Anti - inflammatory Drug ) Fever Strides Arcolabs ltd
21
Indian Scenario - Ibuprofen
22
Global Production Ibuprofen
23
Ibuprofen Production Capacities - IOLCP
24
Ibuprofen - Market Share
Domestic Market
Global Market
Indian Market 8000 MT per Annum
Global Market 25,000 MT per Annum
25
Acetic Acid
  • Acetic Acid or Ethanoic Acid Commonly Known as
    Vinegar
  • Sour Taste Pungent Smell
  • Widely used as Chemical Reagent Industrial
    Chemical
  • Derivatives application almost in all fields

26
Applications End Usage Acetic Acid
Application End use User
As in preparation of Pharmaceuticals Eg. In the preparation of Sulphamethoxazole, Chloroquin, Metronidazole etc. IPCA, CADILA ,SR Drugs Intermediates Ltd,Avon Organics Ltd
As in Polyester Staple Fiber industries In making Purified telepthalic acid (PTA) Reliance , Indian Oil , Mitsubishi Chemical Corporation
As Acidulant Preservative Eg Vinegar, Jams, Pickles, Ketchups etc Cremica , Nestle ,Bonn industries ltd,
As in preparation of Acetates Eg. Cellulose acetate, Ethyl Acetate, Zinc acetate, Amyl acetate etc IOLCP, Ester India ltd, Shatabdi Chem. Pvt Ltd, Kashyap Organics Ltd
As a Chemical synthesize solvent For e.g. Monochloroacetic acid (MCA) , Vinyl Acetate Monomer (VAM) Farmson, Swati, Reliance Cellulose products Ltd,S.R.Drugs and Intermediates (P) Ltd,Sree Rayalaseema Hi-Strength Hypo Ltd,Karnavati Chemical
IOLCP is Entering into the Manufacturing of MCA
with the Capacity of 7200 TPA.
27
Applications End Usage- Acetic Acid
Application End use User
As an intermediate in Pesticides Eg. Chlorpyriphos, Acephate Aimco Pesticides Ltd,Bharat Rasayan Ltd,Meghmani Organics Ltd,Rallis India Ltd, Gujarat Ltd,United Phosphorous Ltd
Diketene its derivatives Eg. Monomethyl acetoacetamide, ethyl acetoacetamide, Methylaceto Acetate Colourchem Ltd.,Mumbai ,Indian Dyestuff Industries,Gujarat ,Avon Organics Ltd., Hyderabad
As Tanning agent Laundry sour, printing calico dyeing Nahar spinning , Vardhman , JCT
As Reaction Solvents For gums, resins volatile oils Turpentine and Oil Co, Camphor and allied Co
28
Indian Scenario Acetic Acid
29
Global Production Acetic Acid
30
Acetic Acid Production Capacities - IOLCP
31
Captive Consumption Vs Merchant Sales Acetic Acid
32
Acetic Acid Market Share
Domestic Market
Global Market
Indian Market 4,50,000 MT per Annum
Global Market 92,00,000 MT per Annum
33
Ethyl Acetate
  • Ethyl Acetate or Ethyl Ethanoate Fragrant,
    Colorless Liquid
  • Diverse Industrial Application as Solvent
  • Usage as Synthetic Fruit Essence
  • Flavor in Pharmaceuticals
  • Coextractant of Camphor, Fats, Oils Antibiotics
  • Ability to replace Aromatic Solvents like
    Toulene, Xylene Methyl Isobutyl Ketone.

34
Applications End Usage Ethyl Acetate
Application End use User
As Lacquer sandling sealer, Glasswood lacquer, Lacquer thinner, LP inks, quickset inks, heatset coldset inks etc Inks Paints Industry Berger Paints India, Goodlac Nerolac Paints Ltd, Resins Solvents,Camlin Ink Pvt Ltd,Kores India
As a media Solvent / wraper shining and protection Flexible Packaging lamination Uflex Ltd , Dharmapal Satyapal industries , PG foil Ltd ,Cosmo films ltd,Essel packaging
For production of Glues etc. Adhesives Converter Adhesives Chemicals Ltd
In Pharmaceutical Rantidine HCL Sulphamethoxazole etc IPCA, CADILA ,SR Drugs Intermediates Ltd,Avon Organics Ltd,Shasun
For creating lustre in photgraphic films to last long Photographic Films Plates Kodak 
Solvents for nitrocellulose lacquers , varnishes and thinners.Least toxic of organic solvents Surface coatings and thinners Godrej,Schenectedy,Bakelite Hylam
Extensively used in the preparation of synthetic fruit essences, flavours and perfumes Flavours and essences Privi Organics, Vadilal Industries Ltd , Narula foods
35
Indian Scenario- Ethyl Acetate
36
Global Production- Ethyl Acetate
37
Ethyl Acetate Production Capacities - IOLCP
38
Ethyl Acetate - Market Share
Domestic Market
Global Market
Indian Market 1,90,000 MT per Annum
Global Market 14,00,000 MT per Annum
39
Acetic Anhydride
  • Ethanoic Anhydride or Acid Anhydride
  • Declared As Controlled Substance under the
    Narcotics Drugs Psychotropic Substances (NDPS)
    Act 1985 by Narcotics Control Bureau, India
  • Usage in Pharmaceutical, Agrochemical, Dyes
    Pigments, Cellulose Acetate Production

40
Applications End Usage-Acetic Anhydride
Application End use User
Drugs Pharmaceuticals Eg. In the making of Paracetamol, Aspirin, Caffeine, Theophylline, Ephedrine HCl Sri Krishna Pharmaceuticals Ltd ,Triton Laboratories Ltd, Ltd,Granules India , Kudos Chemie
Agrochemicals E.g. Acephate Aimco Pesticides Ltd,Bharat Rasayan Ltd,Meghmani Organics Ltd,Rallis India Ltd, United Phosphorous Ltd
Perfume Industry E.g. Acetanilide Maschmejir Aromatics (India) Ltd ,Hindustan Polyamide,Camphor Allied Products, Gujarat
As an reactive agent E.g. Vinyl Acetate Monomer  Jubliant Organysys Ltd, Vinyl Chemicals Ltd
Dyestuff Intermediaries E.g. Acetyl Chloride Gujarat Industrial Chemicals Corporation, Gwalior Chemical Industries Ltd, Indu Organic Chemicals, Amarjas Chemicals, Praveen Organics
IOLCP is installing the Manufacturing Plant of
Acetyl Chloride with the Capacity of 5200 TPA.
41
Indian Scenario-Acetic Anhydride
42
Global Production- Acetic Anhydride
43
Acetic Anhydride Production Capacities - IOLCP
44
Acetic Anhydride - Market Share
Domestic Market
Global Market
Indian Market 55,000 MT per Annum
Global Market 2,00,000 MT per Annum
45
Upcoming ProjectsMCA Acetyl Chloride
  • 1. Producing MCA without using hydrogenation.
  • 2. MCA Plant is equipped with bubble cap
    graphite
  • distillation Column instead of packed column.
  • 3. Plant is equipped with Scrubbing System to
    take
  • care of Environment Aspects.
  • 4. In the Plant 900 critical parameters
    controlled by
  • DCS for maintaining product quality and
    quantity

46
Contd..
  • 5.Plant is based on forward and backward
    integration of existing products.
  • 6.Acetyl Chloride is manufactured with HCL root
    instead of other root to reduce its cost and
    byproduct.
  • 7.Process Parameters are designed using
    Simulation Software CHEMCAD Supplied by
    Chemstations USA.
  • 8.Equipped with Teflon coated pipe and fitting to
    minimize maintenance problem.

47
Iso Butyl Benzene
  • 1.IBB Plant is equipped with
  • Pneumatic transfer System
  • instead of pumps to save
  • power.
  • 2.In the Plant 1400 Critical
  • parameters controlled by
  • DCS to maintain product quality and Yield.
  • 3.In the Plant Air Compressors are equipped with
  • Variable Frequency to get Energy Efficiency.
  • 4. IBB Plant is the Backward integration of
    existing
  • product of IOLCP.

48
Manufacturing Consumption (India) (
MCA, IBB, Acetyl Chloride )
49
Manufacturer's in India
MCA Acetyl Chloride IBB
S.R Drugs and Intermediates Ltd Excel Industeries Limited Vinati Organics
Reliance Cellulose Aqua Pharma SI Group
Meridian Chem-Bond Ltd Gwalior Chemicals India Ltd
Anugrah In-Org ( P ) Ltd Sanghvi Organics Pvt Ltd
Kanrnavati Seem Products
A.V.Organosys Rencal Chemicals India Ltd
Abhishek Impex Misc-Others
Deedy Chem
Maruti Organics
ACI Ind
Swati Chemicals
50
Upcoming Diversification PlansAnti-ulcerants-
Proton Pump Inhibitors (PPIs)
  • The company has planned for installation of new
    manufacturing facilities of PPIs- i.e.
    Rabiprazole, Omeprazole, Esomeprazole,
    Lansoprazole Pantoprazole .
  • Rabiprazole is used to treat conditions where the
    stomach produces too much acid, including ulcers,
    gastroesophageal reflux disease (GERD), and
    Zollinger-Ellison syndrome.
  • The total amount of Capital Expenditure will be
    about Rs 100 Crores ( approx USD 20.83 million).
  • The Project of Rabiprazole is planned to be
    implemented from 2009-10.

51
Proton Pump Inhibitors (PPIs)
  • Bind to Proton Pump and Prevent it from Producing
    Acid in to the Stomach.
  • Usage in Treatment of Variety of Gastric
    Ailments.
  • Generally have More Potent Effect on Suppressing
    Acid than H-2 Blockers ( like Ranitidine,
    Cimetidine, Nizatidine ).
  • PPIs Available
  • - Rabeprazole
  • - Lansoprazole
  • - Omeprazole
  • - Pantoprazole
  • - Esomeprazole

52
Comparison of PPIs and Antacids
PPIs ANTACIDS
Prevent Secretion of Gastric Acid by Inhibiting Proton Pump in Stomach. Neutralize Gastric Acid. e.g. Aluminium Hydroxide Magnesium Hydroxide.
Their Onset of Action is comparatively late but have comparatively very Long Duration of Action. They Provide Faster Relief from Heartburn but have very Brief Duration of Action.
Work in Gastric Lumen. So Useful in Almost All Gastric Ailments. Work almost in Esophageal Lumen which Limits its Use only for Spontaneous Relief from Heartburn.
Very Low Rate of Recurrence of Disease. Rate of Recurrence of Disease is Higher.
Ref www.medscape.com/viewarticle/464898
53
Comparison of PPIs and H-2 Blockers
PPIs H-2 Blockers
Prevent Secretion of Gastric Acid by Inhibiting Proton Pump in stomach. Prevent or Block Histamine from Stimulating the Production of Acid. e.g. Cimetidine, Famotidine, Nizatidine Ranitidine.
Works at the Site where Acid is being made. Thats why More Effective in Suppressing Gastric Acid secretion Works at the Site which Stimulates the Production of Gastric Acid.
Longer Duration of Action, more than 24 hrs. Duration of Action is 2-3 hrs
Comparatively More Efficacious in Treatment of GERD, Gastric Ulcers and Healing of Erosive Esophagitis Comparatively Less Efficacious in Treatment of GERD, Gastric Ulcers and Healing of Erosive Esophagitis.
Dose is 20 mg / day. Usual Dose is 300 mg / day, but Long Term 150 mg / day
1.Am J Gastroenterol. 2000 Apr95(4)936-42 2.
Dig Dis Sci. 2001 Mar46(3)587-96 3. ISSN
1007-9327 CN 14-1219/R World J Gastroenterol
2005 July 1411(26)4067-4077
54
Applications End Usage- PPIs
Application End Use User
Pharma Industry as an ANTI- ULCER Drug Dyspepsia Dr Reddys Lab.
Pharma Industry as an ANTI- ULCER Drug Peptic ulcer Disease Cipla
Pharma Industry as an ANTI- ULCER Drug GERD / GORD Mankind
Pharma Industry as an ANTI- ULCER Drug Zollinger - Ellison Syndrome Lupin Labs.
Pharma Industry as an ANTI- ULCER Drug Gastrinomas Aurobindo Pharma
Pharma Industry as an ANTI- ULCER Drug Barretts Syndrome Nicholas
55
Indian Scenario of PPIs
56
Global Scenario of PPIs
Capacity In MT
Years
57
Growth Potential
  • Potential for growth of these products is
    demonstrated by their growing usage in various
    industries.
  • While the demand growth is being accompanied by
    an increase in production capacities, there is
    still a significant projected demand supply gap
    for these products in the market.
  • Ethanol, major raw material, available in
    abundance from Distilleries of Punjab UP.
  • Companys markets for these products are being
    significantly enhanced with the commencement of
    Indian Oils Refinery nearby at Panipat from
    another upcoming HPCL-Mittal Refinery nearby at
    Bhatinda

58
Organisation Chart
59
Manpower
60
Recognition
Awarded with 2nd National Energy Conservation
Award Consecutively for the Years 2005,
2006,2007 2008 By Ministry of Power,
Government of India
61
Commitment to Quality
  • The Company is committed to utilizing
    state-of-the- art and globally competitive
    technology in its manufacturing and processing
    facilities.
  • High Quality Products with Quality Checks at
    each and every stage, starting from Raw Material
    to Finished products with latest Technology
    Instruments.

62
Certifications
  • Certificate of Pharmaceuticals
    Product-WHO for Ibuprofen.
  • Certificate of Foreign Drug Manufacturer
    from Japan.
  • Koshar Certificate for all finished
    products
  • Halal Committee Registration Certificate
    for Finished products
  • ISO 90012008 for Quality Management
    System
  • ISO 140012004 for Environmental
    Management System
  • Certificate for Foreign Trade Policy-STAR EXPORT
    HOUSE

63
Corporate Ethics
  • The company believes that adherence to the
    corporate ethics and transparent working results
    in substantial and sustainable improvements in
    the performance. The Company has adopted the
    following practices
  • Code of Corporate Governance Conduct
  • Code to Prevent the Insider Trading
  • Code of Corporate Disclosure of Insider
    Trading
  • Whistle Blower Policy

64
Process Automation Distribution Control Based
Operations
  • Complete Automation of Process
  • Computerized Parameter recording
  • Better control of Process Parameters
  • - Operations on single mouse click

65
Our Technical Specializations
REACTION
SEPARATION
DISTILLATION
66
Research Development
  • Equipped with latest infrastructure
  • Highly competent research team
  • Manufacturing technology for all the products
    developed in-house
  • Capacity to produce single to multi-kilogram
    quantities of organic compounds
  • Pilot plant studies for new products / molecules
  • ChemCAD (Simulation Software)

67
Energy Saving Measures
  • Energy Conservation - Major Emphasis Area
  • The most cost effective way for sustainable
    energy development is by improving end-use
    efficiency.
  • We Utilize Waste Process Energy to produce
    660 TR/Day of Chilled Water generated through
    VAM Machines.

68
Environment Friendly Plant
Untreated Effluent Treated
Effluent Standard pH 4.0 - 5.0 7.0
8.0 7.0 - 8.0 TDS (mg/L) 2100 - 2500
1600 - 1800 lt2100 BOD (mg/L) 10000 - 12000
20 - 30 lt 30 COD (mg/L) 14000 - 18000
175 - 200 lt 250
69
  • Contact Us
  • Head Office 85 , Industrial Area
    A
  • Ludhiana-
    141003 India
  • Tele 91-161-2225531-35
  • Fax
    91-161-2608784 , 2226929
  • Works Village
    Fatehgarh Channa

  • Mansa Road Barnala-148101
  • Tele 91-1679-285285-88
  • Fax 91-1679-285292
  • Contact Persons Mr Varinder Gupta

  • varindergupta_at_iolcp.com
  • Mr. Rakesh
    Mahajan

  • rakeshmahajan_at_iolcp.com

70
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