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Metabolic Disorders Related to Carbohydrate Metabolism

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Metabolic Disorders Related to Carbohydrate Metabolism Metabolic Disorders Related to Carbohydrate Metabolism Acidosis Laminitis (founder) Liver abscesses Diabetes ... – PowerPoint PPT presentation

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Title: Metabolic Disorders Related to Carbohydrate Metabolism


1
Metabolic Disorders Related to Carbohydrate
Metabolism
2
Metabolic Disorders Related to Carbohydrate
Metabolism
  • Acidosis
  • Laminitis (founder)
  • Liver abscesses
  • Diabetes

3
Acidosis in Ruminants
  • Decreased pH of body fluids

Lactic acid production
CHO supply
Rumen pH
Systemic acidosis
Rumenitis
Laminitis
4
Laminitis
  • Lameness due to lactic acidosis
  • Chronic inflammation of hoof
  • Abnormal growth
  • Inadequate perfusion of laminae
  • Degeneration of bond between hoof and bone

5
Liver Abscesses
High Grain Diet
Rumen
Portal blood
Liver
Acidosis Rumenitis Bacteria
Liver abscesses
Rumen bacteria
6
Diabetes
  • Diabetes insipidus
  • Diabetes mellitus
  • Excessive urination, water loss
  • Due to shortage of antidiuretic hormone (ADH)
  • ADH causes H2O reabsorption in the kidney
  • Lack of insulin or lack of insulin response
  • Blood glucose is not metabolized or utilized
  • Loss of glucose in urine
  • Ketosis can occur, shift from CHO to fat
    metabolism

7
Diabetes
  • Type I
  • Type II
  • Gestational
  • Pancreas islet cells destroyed
  • Decreased production of insulin
  • Non-insulin dependent
  • Insulin receptors less functional
  • Occurs in pregnant woman

8
Glucose in Cats
  • True carnivore
  • VERY little carbohydrate in normal diet
  • Must rely on gluconeogenesis
  • No VFAs like herbivores
  • Rely on amino acids as source of carbon
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