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Manitoba’s Health Sciences

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BIOAWARE 1.5 Biography David Blicq: Instructor - Chem. Biosciences RRC ISO Research Manager (Biodiagnostics) Researcher NSERC (UM) Consultant (strategic development ... – PowerPoint PPT presentation

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Title: Manitoba’s Health Sciences


1
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2
BIOAWARE 1.5
Opportunity Innovation
Life Sciences in Manitoba
3
Biography
  • David Blicq
  • Instructor - Chem. Biosciences RRC
  • ISO Research Manager (Biodiagnostics)
  • Researcher NSERC (UM)
  • Consultant (strategic development)
  • Multimedia learning resource design

4
Agenda
  • Employment numbers (life sciences)
  • Health sector activities
  • Types of work environments
  • Research
  • Production
  • Quality Assurance / Control
  • Health companies
  • Health research

5
Employment figures
  • Life sciences sector 4,200 employees
  • 41 companies (17 agri-food, 22 biomedical, 2
    environmental)
  • 2300 are in 5 companies (Cangene, Biovail,
    Apotex, Monsanto VitaHealth)
  • 30 research and development establishments employ
    1900 people
  • There are 23 service firms that support the life
    sciences industries.

6
Life Sciences Activities
  • Pharmaceutical research production
  • Infectious diseases
  • Cardiovascular diseases
  • Cancer / oncology / child health
  • Non-invasive biodiagnostics
  • Molecular biology, Mapping Gene Cloning
  • Proteomics Bioinformatics

7
Life Sciences Activities
  • Bacterial Fermentation Metabolic Engineering
  • Marker-assisted Gene Selection
  • Proteomics
  • Level 3 4 Bio-containment
  • Biological Mass Spectrometry
  • Role of nutrition in health

8
Work Environment
  • Three Main Areas
  • RD Research and Development
  • Production
  • QA/QC Quality Assurance / Quality Control

9
Research Team
  • Works in a laboratory environment
  • Find product / idea with value
  • Characterize composition, potency, etc.
  • Establish product specifications
  • Develop analytical / manufacture methods
  • Microbiological considerations
  • Raw materials equipment specifications

10
Research Job Titles
  • Scientist
  • Research Scientist
  • Research Associate
  • Research Technician
  • Laboratory Technician
  • Laboratory Scientist
  • Media Preparation Technician

11
Production Team
  • Works in a Production (GMP) facility
  • Makes the product biochemical, etc.
  • Work with large volumes / equipment
  • Routine operation, cleaning, calibration and
    maintenance of equipment
  • Monitoring and control
  • Follow SOP (standard operating procedure)
  • Complete forms, labels, log-books (GMP)

12
Production Job Titles
  • Manufacturing Operator
  • Manufacturing Technician
  • Manufacturing Supervisor
  • Production Technician
  • Pilot Plant Operator
  • Pilot Plant Technician

13
QA / QC Team
  • Works in office, lab and inspects facility
  • Monitor equipment, facilities, personnel, product
  • Review all production procedures
  • Ensures document / record accuracy
  • Test samples of product and raw materials
  • Compare results to established standards
  • Approve product release

14
QC / QA Job Titles
  • Quality Assurance Technician
  • Quality Control Technician
  • Assay Analyst
  • Documentation Specialist
  • Compliance Specialist
  • Internal Auditor

15
Work Environments
  • Life Sciences Regulated Industries
  • Strict controls for materials affecting human
    health
  • Facilities have to meet exact requirements
  • Methods have to be inspected and approved (Health
    Canada, FDA, etc.)
  • People have to trained, tested and authorized to
    participate

16
Work Environments
  • Academic / Gov. Research
  • University or Research Organization lab
  • Investigate fundamental problems in biology /
    chemistry (etc.)
  • Product is knowledge or information
  • Research may have to be validated following GLP /
    ISO
  • Require degree(s)

17
Work Environments
  • RD Laboratories in Industry
  • Work in-house laboratory (small / large)
  • Investigate with intent of a commercial product,
    conduct scale-up / pilot plant
  • Focused, aggressive, highly effective
  • Work conducting following recognized protocols
    ISO, GLP, etc.
  • Require diploma / degree

18
Work Environments
  • Production Facilities
  • Warehouse-scale manufacturing operations
  • May be highly sanitary
  • May be noisy and damp
  • Can be simple job or highly complex
  • Entry from college / high school

19
Work Environments
  • Testing Labs (QA, Microbiol, Clinical)
  • Independent or governmental labs
  • Perform tests on samples / devices
  • May be highly routine
  • May be occasionally variable
  • Facility is often certified GLP / ISO
  • Diploma / degree required

20
Health Companies
21
Health Companies
  • Apotex Fermentation Inc.
  • AFI uses fermentation-based technologies for the
    production of Active Pharmaceutical Ingredients
    (APIs).
  • The Winnipeg facility is the largest
    fermentation-based GMP facility in Canada.

22
Health Companies
  • Biovail Corporation
  • Formulation, clinical testing, manufacturing of
    pharmaceutical products.
  • Biovail has operations in the US and Canada, and
    a research facility in Ireland.

23
Health Companies
  • Medicure Inc.
  • Development of drugs for cardiovascular diseases
    and stroke.
  • The company's lead product, MC-1, reduces
    ischemic injury caused by restrictions in blood
    flow.

24
Health Companies
  • Viventia Biotech Inc
  • Innovative therapeutics based upon the human
    immune response to cancer.
  • Develops monoclonal antibodies to fight multiple
    forms of cancer.

25
Manitoba Research
26
Infectious Diseases
  • Canadian Science Centre for Human and Animal
    Health (CSCHAH)
  • A leading research location for infectious
    disease
  • Study human pathogens zoonotic diseases, prion
    diseases, influenza virus, enterics, STDs,
    hepatitis, tuberculosis, genomics, antimicrobial
    resistance, foreign animal diseases.

27
Infectious Diseases
  • Canadian Science Centre for Human and Animal
    Health
  • The laboratory is the first and only global
    centre with level-4 bio-containment capabilities
    for the study of both human and animal diseases.

28
Cardiovascular
  • Institute of Cardiovascular Sciences
  • Involved in drug discoveries for the treatment of
    heart failure, ischemic heart disease, and
    diabetes.
  • Located at the St. Boniface General Hospital
    Research Centre

29
Nutrimedicine
  • National Centre for Agri-food Research in
    Medicine
  • Within St. Boniface General Hospital Research
    Centre
  • Studies health-related benefits of natural health
    products
  • Evaluates health benefits, medical side effects,
    athletic performance through research and
    clinical trials.

30
Clinical Trials
  • I.H. Asper Clinical Research Institute
  • Links basic medical research programs at the St.
    Boniface General Hospital Research Centre with
    patient care.
  • Conducts Phase I and Phase II clinical trials on
    cutting edge pharmaceuticals for heart disease
    stroke.

31
Medical Diagnostics
  • Institute for Biodiagnostics (IBD)
  • The National Research Council's IBD investigates
    instrumentation and methods for noninvasive
    diagnosis of serious health conditions (cancer,
    arthritis, heart disease, neurological
    conditions, and osteoporosis).
  • Has the largest concentration of MRIs and NMRs
    for RD purposes in Canada.

32
Child Health
  • Manitoba Institute of Child Health
  • Dedicated to pediatric research
  • Has expertise in developmental pharmacology,
    respirology, genetics, and toxicology.

33
Oncology
  • CancerCare Manitoba
  • A key RD facility (HSC) involved with the
    prevention, care, and research of cancer
  • Recently constructed a 3 million breast cancer
    research facility (HSC)
  • Also involved with Radiation Protection
    consultations and measurement services.

34
Oncology
  • Manitoba Institute of Cell Biology
  • Studies the molecular origins of cancer and the
    role of signal transduction pathways in
    regulating cell proliferation.
  • Also involved in developing markers of risk of
    developing invasive breast cancer

35
Oncology
  • Genomic Centre for Cancer Research and Diagnosis
    (GCCRD)
  • Conducts research in genomic instability and
    mechanisms of neoplasia (formation of new
    tissue).
  • GCCRD is part of the Manitoba Institute of Cell
    Biology (MICB), CancerCare Manitoba, and the
    University of Manitoba.

36
Oncology
  • Mammalian Functional Genomics Centre
  • Creates diverse human disease models in mice, for
    rapid assessment of gene function.
  • Created a library of mouse embryonic stem cells,
    each with a defined mutation in a cellular gene
    to help disease modeling

37
Proteomics
  • Manitoba Centre for Proteomics
  • Analyzes human inflammatory diseases using
    proteomic approaches and identifies biomarkers
    for these diseases.
  • The Centre is partnered with Applied Biosystems,
    Ciphergen Biosystems, and Chemicon International
    Corp.

38
Proteomics
  • Biomedical Proteomics Program, University of
    Manitoba
  • The Biomedical Proteomics Program seeks to
    connect basic biological, agricultural and
    biomedical scientists with those scientists
    developing instrumentation and analytical
    software.

39
  • 32,000 students, 110-plus programs
  • Applied Biopharmaceutical Processing
  • Applied Biology
  • Applied Chemistry
  • Applied Pharmaceutics
  •  Chemical and Biosciences Tech Co-op
  • Environmental Protection Technology
  • Medical Laboratory Sciences
  • Medical Radiologic Technology
  • MRI and Spectroscopy
  • QA/QC in Pharmaceutical Industry

40
Chemical and Biosciences Technology
  • 2-year applied program at RRC
  • Features
  • Co-op job placement
  • Exceptional laboratory training
  • Provides skills employers want
  • Enormous range of grad opportunities
  • Joint 4-year degree program with UW

41
Additional Resources
  • Bioscience Websites - David Blicq / RRC
  • Science Job postings
  • Manitoba Bioscience news
  • Course summaries and lab manuals
  • Resumé and Cover letters
  • On-line courses (viewable content)

42
Additional Resources
  • Other Content
  • Study skills for science
  • Employer-requested skill-sets
  • Interview tips
  • Lab documentation GLP / ISO
  • Student pages

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BIOAWARE 1.5
Opportunity Innovation
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