Bank your Baby s Cord Blood Stem Cells and secure your

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Bank your BabysCord Blood Stem Cellsand secure
your familys Health
_at_ Your Stem
Cell Bank
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Why Stem Cells ?

• Self renewal capacity.
• Long term culture mode.
• Elevated proliferation rate.
• Insignificant response to naïve cord blood T
  cells.
• Extremely high probability of cure.
• Master cells.
• Repair, Regenerate Replace damaged cells.
• Form heart, liver, nervous system, spinal cord
  etc.
• Over 200 types of tissues Clinical
  significance.
• Ability to divide, differentiate continuously
  to address diseases like Heart failures,
  Alzheimers, Parkinsons, Thalassemia, Leukemia,
  Liver, Diabetes problems.

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Sources of Stem Cells
Stem Cell
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Umbilical Cord/Blood

• Umbilical Cord/Blood Stem Cells
• Traditional discard - by-product of the birth
  process
• Multipotent - stem-cell - rich blood found in the
  umbilical cord has proven useful in treating the
  diseases
• Umbilical cord blood stem cell transplants - less
  prone to rejection than either bone marrow or
  peripheral blood stem cells - the cells have not
  yet developed the features that can be recognized
  and attacked by the recipient's immune system

• Also, because umbilical cord blood lacks
  well-developed immune cells, there is less chance
  that the transplanted cells will attack the
  recipient's body, a problem called graft versus
  host disease
• Versatility and availability of umbilical cord
  blood stem cells - potent resource for transplant
  therapies
• These cells have no morbidity, it is possible to
  isolate huge numbers and they do not belong to an
  ethically controversial source

Fewer limitations - not tumorigenic, maintain for
several serial passages - short population
doubling time
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Advantages...Cord/Blood Source

• Collection process is easy
• There is no harm done either to the mother or the
  baby
• High probability of HLA matching
• Medical waste Rich source of high therapeutic
  potential stem cells

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Cord Blood Easier Safer
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Adult Stem Cells

• Peripheral Blood Stem Cells
• While most blood stem cells reside in the bone
  marrow, a small number are present in the
  bloodstream. These multipotent PBSCs, can be used
  just like bone marrow stem cells to treat
  leukemia, other cancers and various blood
  disorders
• PBSCs are easier to collect than bone marrow stem
  cells
• PBSCs - less invasive treatment option than bone
  marrow stem cells
• PBSCs are sparse in the bloodstream
• Collecting enough to perform a transplant can
  pose challenge

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Adult Stem Cells - Sources

• Present throughout the body from head to toe
• Brain
• Liver
• Skin
• Dental pulp
• Adipose tissue
• Placenta
• Menstrual blood
• Synovial fluid
• Umbilical cord
• Heart
• Pancreas
• Intestine

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Adult Stem Cells

MSC are the most preferred cell types in
clinical applications During the past 50 years,
intensive studies into the characteristics of
hematopoietic stem cell transplantation
immunology with the emergence of new
immunosuppressant and anti-infective drugs have
significantly improved the clinical result of
hematopoietic stem cell transplantation .
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Advantageous Features

• Already somewhat specialized Inducement may be
  simpler
• Immune hardy Recipients who receive the products
  of their own stem cells will not experience
  immune rejection
• Flexible Adult stem cells may be used to form
  other tissue types
• Mixed degree of availability Some adult stem
  cells are easy to harvest and others, such as
  neural (brain) stem cells, can be dangerous to
  the donor

The surprising property of adult stem cells
transdifferentiation
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CB Stem Cells For Patients Suffering from

• Acute Leukemia
• Chronic Leukemia
• Myelodysplastic Syndrome
• Myeloproliferative Disorder
• Lymphoproliferative Disorder
• Familial Erythrophagocytic
• Lymphohistiocytosis
• Histiocytic Disorder
• Inherited Metabolic Disorder
• Platelet Abnormality
• Plasma Cell Disorder
• Thalassemia
• Other Malignancies

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What is a Stem cell transplant?

• Infusion of healthy cells to replace diseased or
  damaged ones
• The healthy replacement stem cells will
  integrate into the body and give rise to more
  cells that can all take on the necessary
  functions for a specific tissue

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Diseases Treatable by Stem Cell Transplantation

• Today
• Leukemia's
• Lymphomas
• Multiple myeloma
• Radiation sickness
• Autoimmune Dx
• Tissue repair and Burns
• Breast and Ovarian cancers

• Near Future
• Diabetes
• Cardiovascular Dx
• Spinal Cord Injuries
• Skin Rejuvenation
• Rheumatologic
• Orthopedics
• Stroke

Sources include www.marrow.org www.viacord.com
www.cryo-cell.com
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Stem Cells in Gynecology Obstetrics
For Solid Tumors Renal Carcinoma Melanoma Ovarian
Cancers Metastatic Breast Cancers In utero HSC
transplantation In vitro Generation of
Gamestes Treating Abdominal Wall
Defects Umbilical Hernia Spina Bifida
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Flexibility
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Who Should Bank Their Stem Cells

• Health conscious individuals
• Individuals with family history of cancer,
  diabetes and heart diseases
• Individuals diagnosed with cancer
• Individuals - exposed to toxins or harmful
  radiation because of their jobs
• First responders, who may be exposed to lethal
  levels of radiation

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Why Tran-Scell ?

• Tran-Scell is state of the art stem cell banking
  and processing centre.
• Tran-Scell is highly equipped with expertise and
  optimal microenvironment for processing and
  preserving your childs precious stem cells for
  all the potential future medical requirements.
• Personal commitment from enrollment, collecting
  the source, processing the stem cells,
  cryopreserving the customized stem cell units for
  future therapeutic options, reporting associated
  with safe service delivery.

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• Stringent quality control and quality assurance
  ensured.
• Standard operating procedures and automated
  processing protocols followed.
• Samples are stored in an fire and earthquake
  proof vaults with 24x7 monitored ambience.
• Emergency UPS, Access restriction systems and
  Backup arrangements installed.

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Services _at_ Tran-Scell

• Umbilical Cord Blood Collection, Processing
  Storage of Haemopoitic stem cells.
• Umbilical Cord Tissue Collection, Processing,
  Cell expansion Storage of harvested Mesenchymal
  stem cells.
• Processing of Bone Marrow for adult stem cells
  storage.
• Processing storage of Peripheral Blood stem
  cells.
• Generation of stem cells from various sources for
  therapeutic applications on various dread full
  diseases.
• Private Banking facilities.

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Research _at_ Tran-Scell

• Isolation Expansion of Stem cells from Dental
  Pulp for therapeutic application on dental
  disorders.
• Isolation Expansion of Acinar cells from Human
  lacrimal gland for treating Dry eye syndrome.
• Isolation of stem cells from Human adipose
  tissue.

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_at_ Tran-Scell?

• Safety and Security
• Tran-Scell maintains optimal conditions for
  processing and storing stem cells
• Quality control measures for each stage of the
  stem cell banking process

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Processing

• Automated Processing using SEPAX.
• Manual processing allows trained scientists to
  perform quality control at every step
• Standard Operating Procedures Batch wise
  specifications
• Certificate of Analysis of the final finished
  personalized product
• On average, the process employed recover over 90
  of total nucleated cells and high density of
  mesenchymal stem cells from the sample

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Storage

• Initial quarantine
• Long-term storage in liquid nitrogen maintains
  temperatures at -196C, far below the recommended
  minimum standard for storage at -150C
• On-site tank feeds a constant supply of liquid
  nitrogen, even during a power outage
• Electronic systems constantly monitor temperature
  and liquid nitrogen levels
• Functional In-built remote alarm system

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Advantage with Tran-Scell

• HLA for every sample
• Associate Banking
• Formulation
• For Immediate Therapy Future Applications
• Application Specific
• Duplicates Multiple Vials
• Expansion Whole Diseases Management
• Automated and Semi automated process
• Regenerative medicine factor

FDA APPROVED REAGENTS
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Alone we can do so little together we can do so
much.
Thank You