Prevention and Treatment - PowerPoint PPT Presentation

Loading...

PPT – Prevention and Treatment PowerPoint presentation | free to download - id: 3b0c37-MzE3M



Loading


The Adobe Flash plugin is needed to view this content

Get the plugin now

View by Category
About This Presentation
Title:

Prevention and Treatment

Description:

* * cancer therapies Cabrera 2010 * * cancer therapies Cabrera 2010 * * cancer therapies Cabrera 2010 * * cancer therapies Cabrera 2010 All meats ... – PowerPoint PPT presentation

Number of Views:90
Avg rating:3.0/5.0
Slides: 59
Provided by: Thierr45
Category:

less

Write a Comment
User Comments (0)
Transcript and Presenter's Notes

Title: Prevention and Treatment


1
Prevention and Treatment of Cancer with Diet
and Herbs
Chanchal Cabrera
MSc FNIMH AHG
2
Startling Statistics
Cancer is the second leading cause of death in
children and adults in North America. (It is
second to accidents in children and to heart
disease in adults).
3
33 35 Percentage of cancer deaths that
experts link to what we eat. (Journal of
the American Dietetic Association 5, 1
88-91) 18 Percentage of Americans that eat 5
7 servings of fruit and vegetable daily.
(National Cancer Institute) 35 Percentage
of fruit and vegetables eaten daily in America
in the form of French fries and potato chips.
(National Cancer Institute)
4
50 How much we can reduce our risk of death from
cancer, heart disease and other chronic ailments
when we exercise. (New England Journal of
Medicine 345 793-801)
5
diet
smoking
hormones
infection
alcohol
EMF
toxins
inactivity
work
(The Cancer Prevention Book, Rosy Daniel MD,
Hunter House)
6
Immune system activation / regulation
Hormonal modulation detoxification
Inhibition of Inflammation
Management of symptoms
Cytotoxic and apoptotic activating agents
Anti angiogenic pathways
Modulators of growth factors and CAM
7
Some key features of cancer cells Aberrant DNA ?
functional and structural protein changes ?
up-regulation of growth factors and their
receptor sites, immune evasion or
suppression Defective Krebs cycle little
energy derived that way High rate of glycolysis
and high demand for sugar Low requirement for
oxygen Production of lactic acid contributes to
local inflammatory environment Loss of controls
of cell cycling Crowding and eventual recruitment
of adjacent cells Requirement for new blood
vessels angiogenesis Metastasis and invasion
8
Anti-tumorigenics Calendula officinalis
(Marigold) Camellia sinensis (Green
tea) Chelidonium majalis (Celandine) Corydalis
ambigua (Corydalis) Curcuma longa (Turmeric)
9
Juglans nigra (Black walnut) Phytolacca spp.
(Pokeroot) Podophylum peltatum (Mayapple) Rosmarin
us officinalis (Rosemary) Schizandra chinensis
(seed) (Schizandra) Thuja occidentalis (Arbor
vitae) Viola odorata (Sweet violet) Vitis
vinifera (Grape leaf, seed skin)
10
Artemisia annua Bitter, acrid and cooling. Used
in TCM to clear damp heat. Artemisinin is a
sesquiterpene lactone with 2 oxygen atoms linked
by an endo-peroxide bridge. This readily reacts
with iron to form free radicals ? oxidative
stress to cell. Preferentially taken up with
iron therefore test for iron, ferritin, total
iron binding capacity and soluble transferrin
receptors
11
ART inhibits multi drug resistance pathways
Decreases mitochondrial membrane potential in
cancer cells leading to 30 50 decrease in
available cellular energy. Pulse dose alternate
weeks in increasing doses
12
Week one taken with grapefruit juice ART 150 mg
(1 cap) twice daily Butyric acid up to 10
g Vitamin C to bowel tolerance H2O2 if
desired Iron if levels are low GLA 1000 mg DHA
500 mg EPA 750 mg Week two Cytotoxics blend
13
Week three ART 150 mg (1 cap) three times
daily Week four Cytotoxics blend Week five ART
300 mg (2 caps) three times daily Week
six Cytotoxics blend Week seven ART 450 mg (3
caps) three times daily
14
Asimina triloba (Annonaceae) Contains over 50
acetogenins, concentrated mostly in the
seed Powerful inhibition of mitochondrial ATP
production Up-regulates p21 Inhibition of multi
drug resistance
15
Liver detox supplements to take before bed
Calcium D glucarate 500 mg Chrysin 50
mg Di-indolylmethane 750 mg Glycine 200 mg
Magnesium 500 mg Melatonin 0.5 15 mg
NAC 1000 mg Selenium 300 mcg Taurine
500 mg Milk thistle seed 500 mg
16
Alteratives Arctium lappa (Burdock) Baptisia
tinctoria (Wild indigo) Crocus sativa (Autumn
crocus) Iris versicolor (Blue flag) Phytolacca
spp. (Pokeroot) Podophylum peltatum (Mayapple)
Rumex crispus (Yellow dock)
17
Scrophularia nodosa (Figwort) Tabebuia spp.
(Taheebo / Pau darco) Thuja occidentalis (Arbor
vitae) Trifolium pratense (Red clover) Uncaria
tomentosa (Cats claw) Urtica dioica leaf, root
seed (Nettle) Zanthoxylum americanum (Prickly
ash)
18
  • 7 KEY PROCESSES IN CANCER DEVELOPMENT
  • Induction of genetic instability
  • Abnormal gene expression
  • Abnormal signal transduction
  • Abnormal cell to cell communication
  • Induction of angiogenesis
  • Invasion and metastases
  • Immune evasion

19
Factors to Consider in Integrative Oncology
  • Specifics of the patient (stress situation,
    weaknesses, other ailments, psychological and
    physical environment, support system, etc.)
  • Specifics of the cancer (Growth factors IGF,
    VEGF, hormones gene mutations, angiogenic rate,
    etc.)
  • Symptoms present (nausea, pain, indigestion,
    etc.)
  • Other treatments (interactions between NHPs and
    conventional medicine chemotherapy, radiotherapy
    or other medication)
  • Other co-existing health conditions

20
1) Tumor biopsy Confirmation and identification
of cancer type and biomarkers, together with drug
sensitivity screening, if applicable
21
1) Tumor biopsy Confirmation and identification
of cancer type and together with drug sensitivity
screening, if applicable 2) Pathology testing
a) Proliferative markers, b) Characteristics
identification of gene mutations and
abnormalities in cell behavior, c) Tissue
biomarkers, d) Growth factors, including
important regulators of angiogenesis
22
  • Blood testing
  • Establishing tumor marker baseline
  • b) Assessing terrain identification of any
    disturbances within the internal environment that
    can and should be altered including nutritional
    status, pH, lipids, inflammation, glucose and
    insulin, and other contributing hormonal
    imbalances, and hypercoagulation.

23
  • Blood testing
  • a) Establishing tumor marker baseline,
  • b) Assessing terrain identification of any
    disturbances within the internal environment that
    can and should be altered including nutritional
    status, pH, lipids, inflammation, glucose and
    insulin, and other contributing hormonal
    imbalances, and hypercoagulation.
  • 4) Building a foundation protocol with botanical
    and nutritional formulations to enhance and
    sustain the vital force, organ systems, immune
    system, and cellular status.

24
5) Formulate a specific, targeted protocol that
integrates the holistic model, the multiple
layers of botanical formulations, and when
appropriate the most useful conventional medicine
treatment options.
25
  • THERAPEUTIC STRATEGIES
  • Restore vitality tonics, adaptogens, bitters,
    nutritives
  • Optimize internal chemistry diet (sugars,
    proteins, fats,
  • fruits and vegetables)
  • Detoxify alteratives, cholagogues,
    diaphoretics, aperients
  • Support immune system deep immune tonics
  • Induce apoptosis in cancer cells flavonoids,
    cytotoxics,
  • anti-neoplastics
  • Enhance cell to cell communication
  • Resist angiogenesis, metastases and immune
    evasion

26
Foods to eat
27
  • Chicken and turkey 1 3 times weekly
  • Grass fed beef, buffalo or venison 1 - 2 times a
    week
  • Fish 3- 4 times a week especially cold-water
    fish such as salmon, sardines, herring, halibut
    and mackerel

28
  • Organically grown grains - brown rice,
    buckwheat, millet, quinoa, barley, amaranth,
    spelt and oats
  • Soaked for 4 hours then slow cooked
  • Lentils, peas, beans, nuts and seeds, free-range
    eggs, organic yogurt. Avoid or minimize
    processed soy products

29
  • To improve digestibility soak beans overnight in
    water, rinse well, cook slowly (a crock pot is
    ideal) and rinse again well after cooking, then
    add to recipe

30
  • Olive and sesame oil, and the balanced
  • blends of omega 3, 6 and 9 fatty acids
  • 2 Tbsp flaxseeds either freshly ground daily
    or soaked overnight in water

31
  • 7 10 servings daily of organic fruit and
    vegetables
  • Emphasize orange, red and purple fruits, citrus
    fruits, berries, garlic, leeks and onions,
    broccoli, cauliflower, brussel sprouts, cabbage,
    kale and other members of the Cruciferae family

32
  • Avocado and cilantro increase glutathione
  • Figs and almonds contain benzaldehydes that
    convert to cyanide
  • Globe artichokes and sunchokes, Burdock root and
    Daikon, Shiitake, Oyster, Crimini and Portobello
    mushrooms
  • Seaweeds and Miso

33
  • Green tea, herbal teas, pure water and fresh
  • squeezed juices
  • Wheat grass, Chlorella, Barley grass or
  • Blue Green algae
  • Filtered or bottled water

34
Foods to avoid
35
  • All meats and fish not named above
  • Commercial white button mushrooms
  • Smoked or preserved meats sausages, salamis,
    cold cuts, canned meats
  • All commercial cows milk products (milk, butter,
    hard and soft cheese, cream, etc.). A little
    organic yoghurt, cultured cheeses and butter is
    acceptable
  • Sugar in all forms, especially all refined and
    processed sugars
  • Peanuts and peanut butter because they contain
    lectins that cause blood clotting

36
Foods for Cancer Prevention
37
  • Allicin - garlic
  • Beta glucan mushrooms, oats, onions, yeast
  • Calcium D glucarate apples, grapefruit,
    grapes, bean
  • sprouts, cauliflower, cabbage
  • Carotenoids carrots, beets, kale, yams, sweet
    potatoes,
  • red peppers
  • Curcuminoids turmeric , ginger, galangal
  • Fiber all fruits and vegetables, psyllium,
    slippery elm,
  • Ellagic acid strawberries, cranberries,
    loganberries,
  • marion berries
  • Epigallocatechin gallate (EGCG) black and
    green tea

38
  • Geraniol from rose geranium and lemon grass
  • Indoles and thiols in cabbage, broccoli, kale,
  • beet tops, turnip, brussel sprouts, collards
  • Isoflavones fermented soy, clover, alfalfa
    sprouts
  • Limonene citrus juice and peel
  • Lycopene tomatoes, other red fruits and
    vegetables
  • Omega 3 fatty acids fish, flax oil, walnuts
  • Polyphenols black and green tea, rooibos tea
  • Selenium shiitake, maitake mushrooms
  • Sulphur garlic, onions, leeks, shallots,
    chives

39
Daily doses for cancer prevention B12
1000 mcg B-6 100 mg B complex 100
mg Bromelain 2400 GDU Carotene Complex
50,000 IU CoQ10 200 mg EPA/DHA n-3
from fish 600 / 300 mg Folic acid 1000
mcg Fresh ground / soaked flax seeds 2 Tbsp.
GLA 1000 mg Glutamine 2 20 g IP6
3 6 g
40
Limonene 500 - 5000 mg Lipoic acid 600
mg Modified citrus pectin 1 Tbsp MSM 2
g Phosphatidyl choline 1 2 g Quercitin 2
g Selenium 300 mcg Vitamin C 1 g Vitamin E
succinate 800 IU Zinc 40 mg
41
Additional items for maximum coverage Active
Hexose Correlated Complex (AHCC) Maitake D
fraction and 1, 3- beta glucans Medium
ChainTriglyerides Molybdenum if the copper
tests high Artemisinin and butyric
acid Resveratrol
42
CUSTOMIZING THE PROTOCOL No single specific
herb No single answer Tri Phasic model
43
Energetic Relationships
endogenous

Energetics of the Human Being (Spirit - Mind -
Body) assess and target the Kidney, Liver and
Spleen energetic systems
Energetics of the surrounding Environment asses
s and target the external environmental contributi
ng factors
Energetics of the Cancer assess and target the
cancers characteristics
exogenous
endogenous /exogenous
44
HERBS THAT CAN BE HELPFUL IN TREATING
CANCER Adaptogens and tonics Camellia sinensis
(Green tea) Cordyceps sinensis (Cordyceps) Curcuma
longa (Turmeric) Eleutherococcus senticosus
(Eleuthero) Ganoderma lucidum (Reishi) Glycyrrhiza
glabra (Licorice) Centella asiatica (Gotu kola)
45
I am an old man now, and I have known a great
many problems in my life most of which never
happened Mark Twain
46
Adaptogens
  • Build vital force
  • Enhance adaptation
  • Sustain energy
  • Support resistance to disease
  • Promote healing
  • Protect against stress

47
(No Transcript)
48
Gallocatechin (GC) Epicatechin (EC) Epigallocatech
in (EGC) Epicatechin gallate (ECG) Epigallocatechi
n gallate (EGCG) Caffeine
49
Camellia sinensis - Pre-clinical studies
  • EGCG induced cell cycle arrest and apoptosis of
    human prostate carcinoma cells 1
  • EGCG results in activation of p53 and induction
    of apoptosis in prostate cancer 2
  • EGCG causes an imposition of artificial
    checkpoint at G1 ? S transition of cancer cells,
    thereby resulting in an arrest of cells in
    G0G1phase of the cell cycle 3

1 Gupta et al., Archives of Biochemistry and
Biophysics 410 (2003) 177185 2 Hastak et al.,
The FASEB Journal express article
10.1096/fj.04-2226fje 3 Ahmad et al., Biochemical
and Biophysical Research Communications 275,
328334 (2000)
50
Camellia sinensis - Clinical studies
  • Regular consumption of green tea post-diagnosis
    can enhance epithelial ovarian cancer survival 1
  • 20 per cent statistically significant reduction
    in risk of breast cancer associated with high
    intake of green tea 2

1 Binns et al., Asia Pac J Clin Nutr.
200413(Suppl)S116 2 Sun et al., Carcinogenesis.
2005 Nov 25
51
Curcuma longa - Pre-clinical studies
  • Anti-inflammatory
  • ? NF-kappaB, COX-2, LOX-5 12, IL-6, TNF-?, and
    ? PG2
  • Anti-arthritic
  • Antioxidant
  • Cardio-vascular health
  • ? HDL Cholesterol and ? VLDL LDL Cholesterol, ?
    blood motility, ? platelet aggregation, plaque
    formation and lipid oxidation
  • ? Gastro-intestinal health
  • Anti-viral
  • Inhibits HIV Replication
  • Liver protective
  • modulates Phase I II enzyme systems, prevents
    alcohol and chemically-induced liver disease

52
Curcuma longa - Pre-clinical studies
  • ? antitumor effect of Gemcitabin in Pancreatic
    cancer by ? proliferation, angiogenesis, NF-KB,
    and NF-KBregulated gene products
  • In vitro ? proliferation of various pancreatic
    cancer cell lines, ? apoptosis induced by
    gemcitabine, and ? NF-KB activation in the cells.
  • In vivo ? volume in tumors from nude mice
    injected with pancreatic cancer cells and treated
    with a combination of curcumin and gemcitabine 1
  • ? immune activity 2

1 Ajaikumar et al., Cancer Res 200767(8)385361
2 Antony et al., Immunol Invest. 1999
Sep-Dec28(5-6)291-303
53
Curcuma longa - Clinical studies
  • Phase I clinical trial showed
  • No toxicity after up to 8,000 mg/day when taken
    by mouth for 3 months
  • biologic effect of curcumin in the
    chemoprevention of cancer 1

1 Cheng et al., Anticancer Res. 2001
Jul-Aug21(4B)2895-900
54
Nigella sativa (Black mustard) Panax ginseng
(Ginseng) Panax quinquefolium (American
ginseng) Rhodiola rosea (Arctic rose) Rosmarinus
officinalis (Rosemary Schizandra chinensis (seed)
(Schizandra) Scutellaria baicalensis (Baical
skullcap) Vitis vinifera (Grape seed and leaf and
skin) Withania somnifera (Ashwagandha)
55
Immune tonics Astragalus membranceous (Milk
vetch) Ceanothus americanus (Red root) Galium
aparine (Cleavers) Glycyrrhiza glabra
(Licorice) Phytolacca spp. (Pokeroot)
Medicinal mushrooms Cordyceps sinensis
(Cordyceps) Coriolus versicolor (Turkey
tails) Ganoderma lucidum (Reishi) Grifolia
fronderosa (Maitake) Lentinus edodes (Shiitake)
56
Ganoderma lucidum - pre-clinical studies
  • In vitro
  • ? cytokine production and T lymphocytes, ? cell
    proliferation, ? apoptosis differentiation of
    leukemic cell lines 1
  • ? NF-kB activity (to enhance cytokine release) 2
  • In vivo
  • antitumor effects 3

1 Wang et al., Int J Cancer 1997 Mar 17
70(6)699-705 2 Kuo et al., Journal of
Ethnopharmacology 103 (2006) 217222 3 Furusawa
et al., Phytotherapy research 1992 6300-304
57
Ganoderma lucidum - clinical study
  • ? IL-2, IL-6, IFN-?, ? NK cell activity
  • ?TNF-? (less body weight loss, nausea, fatigue
    and cancer cachexia)
  • The results of this study suggest the
    possibility that Ganoderma could reverse the
    immunosuppressive effects of traditional
    chemotherapy/radiotherapy in cancer patients, and
    it may represent a practical and promising
    adjunct approach for cancer treatment in
    combination with chemotherapy / radiotherapy. 1

1 Gao et al., J Med Food 8 (2) 2005, 1591682
58
chanchal_at_chanchalcabrera.com
About PowerShow.com