Human Karyotype- (Diploid= 2n)

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Human Karyotype- (Diploid 2n)

• Normal human- how many homologous pairs?
• What is the sex?
• How many chromosomes does each parent contribute?

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What if chromosomes fail to separate properly?
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NondisjunctionFailure of chromosomes to separate
properly during meiosis
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Abnormal Gametes result in abnormal diploid
condition

• SOMATIC TRISOMIES
• Down Syndrome
• Trisomy 13- cleft palate, eye brain circulatory
  defects
• Trisomy 18- death in months
• Trisomy 16-death in months
• SEX CHROMOSOMES TRISOMIES
• Turner Syndrome-X0- only viable monosomy in
  humans, Never mature sexually
• Klinefelter Syndrome XXY
• XYY- Super male- aggression
• XXYY
• NOTE the role of the Y chromosomeits presence
  yields malesness- otherwise default to female

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Cancer Cell Karyotype