Ischaemic Preconditioning of Skeletal muscle Effect in a Knee Arthroplasty Population

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Ischaemic Preconditioning of Skeletal muscle
Effect in a Knee Arthroplasty Population
1,2Murphy, T. 1Walsh, P. 1Murray, D. 1Magill,
P. 1Doran, P. 2Mulhall, K. J. 1UCD Clinical
Research Centre, University College Dublin,
Ireland 2Cappagh National Orthopaedic Hospital,
Dublin, Ireland

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Introduction

• First described by Murry in 1986
• Exact mechanism unknown
• Possible triggers
• Adenosine
• Noradrenaline
• Bradykinin
• Sympathetic nervous system
• Opoids
• 2 phases involved
• Early (initial 3-4 hours)
• Late (from 24hrs to 72hours)

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Study Design

• Prospective randomised control trial
• Ethics approval from Cappagh Ethics Committee
• Elective primary TKR
• Single surgeon population

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Protocol
Elective Primary Total Knee Replacements ? Normal
ankle brachial index (1) ? Clinical
assessment Range of movement and fixed flexion
deformity, knee society score, SF-36 ? Pre-operat
ive baseline blood samples (WCC, HgB, Renal
function, CRP, ESR)
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Protocol
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Protocol
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Results
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P0.08
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Micro-array Results
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Acknowledgments

• Special thanks to Mater College for Postgraduate
  Education and Research for funding
• Staff in Cappagh National Orthopaedic Hospital,
  Dublin, Ireland.

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Thank You