Janice S' Dorman,

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??????1???????
Janice S. Dorman,??
9-4-2001
??Dxyerlone_king Emailrain_mud_at_126.com
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1????
???????????? -???PA,Allegheny??2/1000 ??????1
979?????I???????????? -Dr.Allan Drash ?Dr. Lewis
Kuller
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PA,Allegheny?1???????
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PA,Allegheny?1???????
1-3?
4-6?
7-9?
10-12?
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PA,Allegheny?1???????
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(No Transcript)
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??I???????
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??-????-???? ??????? -??????????? -???? -??(????
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??????????
???????????????? ???????????20-50 ???????????
?????15???????????? ??????????HLA?II??????????
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?5. DQA1?DQB1??????????DQ??
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HLA-?-TCR?????
TCR
??
ß1?
a1?
HLA
ß2?
a2?
??????????
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I?????????
???? ??????? ?????
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I ????????
??HLA?????? ??????????HLA????????,?????????? ??
???????????? ???????????????????? ???????
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I?????????
?6????
?2????
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????????????
????-I????
????-????
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WHO DiaMond???????
???HLA DQ ????????? ???????? IDDM1 HLA
DR,DP IDDM2 INS-VNTR IDDM12 CTLA4 ??
VDR,HLA I ???
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?????WHO??????(DiaMond)
??I????????????????????
???????? 1990-2000
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WHO???????????????
Ron LaPorte, Ph.D. ?????????? Jan Dorman. Ph.D.
??????
?????
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WHO DiaMond???????
?? I??????????????????????????? 20?????? ????
2??1??0?????HLA-DQ???(SS,SP,PP)
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WHO DiaMond??????????
??? ?? ?? ??
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?????????
Plt0.05,???? Allegheny?,PA? Jefferson?,AL ??Hokk
aido?????
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??30????????
Allegheny?,PA? Jefferson?,AL ??Hokkaido?????
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??????
Allegheny?,PA? Jefferson?,AL ??Hokkaido?????
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?????????
????SS?SP(?PP??) ??????????,?????????
????????SS?????????3-6(????)
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??????????
?????, HLA-DQ??????????19-43?I????
??50 ?????HLA-DQ???????????
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??????????(??)
?????????????????1/100,000/? ??????????0.8
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?????????????????1/100,000/? ??????????10
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??I??????????
???????????????????????????? -????? -???? -??????
??DiaMond ??????? ??????????
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(No Transcript)
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??I??????????
1999??????? -Dr, Yang Ze 296???,528???18??? ??
??-?? -HLA DRB1,DQB1?? ?????-??? -GAD,IA-2,TPOAb,
TGAb,C? ????-??? -??,??,?? Dr.Elsa Strotmeyer????
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