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Welcome to Cancer Research UK

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Cancer Research UK. My background. What ... Cancer Research UK - Overview ... Largest single funder of cancer research in UK spending 333 million on research ... – PowerPoint PPT presentation

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Title: Welcome to Cancer Research UK


1
Welcome to Cancer Research UK
2
Developing new medicines to beat cancerKate
Miller
3
Overview
  • Cancer Research UK
  • My background
  • What is Drug Development ?
  • Our IT challenges

4
Why Work in Cancer Research?
  • More than 10 million people per year develop
    cancer worldwide. This is estimated to rise to
    15 million by 2020 (WHO figures).
  • 289,000 new cases of cancer are diagnosed every
    year in the UK.
  • Someone in the UK is diagnosed with cancer every
    2 minutes.
  • More than 1 in 3 of people will develop cancer.
  • Cancer is the British publics number 1 fear.

5
Cancer Research UK - Overview
  • Worlds largest independent organisation
    dedicated to cancer research
  • 4,500 scientists, doctors nurses in more than
    30 cities towns across the UK
  • Largest single funder of cancer research in UK
    spending 333 million on research
  • Over 46,600 volunteers who give around 6.9
    million hours of their time
  • Our research falls into 4 main areas
    Understanding cancer, Treating cancer, Preventing
    cancer, Improving the quality of life for people
    with cancer
  • European leader in development of anti-cancer
    drugs

6
Who am I ?
7
CR-UK 2020 goal
  • There will be better treatments with fewer side
    effects.

8
CR-UK Drug development team
  • What do we do?
  • We provide academic and industrial groups with a
    mechanism for developing their novel oncology
    agents.
  • We give patients with terminal cancer hope when
    no other treatment opportunities are available to
    them
  • How do we do it?
  • We take promising new medicines from the
    laboratory into clinical trials

9
The drug development process
Early-stage research discovery
Regulatory review/ approval
Preclinical studies
Phase I
Phase II
Phase III
Phase IV
2-3 years
1-2 years
? years
1-2 years
1-2 years
1-2 years
CTAAC
Drug Development Office
CRT
10
Our project portfolio - source of new agents ?
11
What happens to the drugs after our studies..?
  • DDO undertakes further studies
  • and/or
  • Company undertakes further studies, or
  • It is dropped - too toxic, does not do what it is
    supposed to
  • To be successful .. it must be taken on by a
    biotech or pharmaceutical company

12
Drug Development Team successes
  • We have advanced gt100 novel agents into early
    phase clinical trials
  • 5 of these have reached the market and another 6
    are currently in Phase III development

13
Temozolomide - a success story
  • Temozolomide was discovered in a CR-UK research
    laboratory.
  • The DDO conducted Phase I II studies
  • CRT licensed the drug to Schering Plough
  • Schering-Plough conducted Phase III study and got
    the drug approved by regulatory authorities
  • Temozolomide sales have now reached 1bn and the
    royalties we receive go straight back into the
    pot to fund further research

14
Drug Development Team - successes
  • We have a patient who has moved from progressive
    to stable disease and has successfully completed
    I year of treatment.

15
Drug Development
  • What are our main IT Challenges ?

16
Our IT strategy
  • To Re-engineer DDO processes and IT
    infrastructure in order to support our strategic
    objective to double drug development activity
    over the next 5 years.
  • Where we are today
  • As-Is Project. Created an interactive map of all
    our current processes / systems / technologies.
  • Thorough understanding of our strengths and
    weaknesses

17
Next Steps
  • Quick Win Projects to shore up our current ways
    of working
  • Investigate buying new technology
  • Investigate renting new technologies
  • Investigate outsourcing models
  • Trial different models
  • Decision

18
Operating in an increasingly regulated
environment
19
Impact of current financial climate
  • Looking at investment in infrastructure during a
    difficult financial climate
  • Explaining to the general public that investing
    in IT is key to improving drug development
  • Ensuring that we spend the publics money wisely

20
  • Thank you
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