Neural Crest Cells

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Neural Crest Cells
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Do Neural Crest Cells Differentiate Before They
Migrate, or After?

• Pluripotency hypothesis
• Migrate as undetermined cells and differentiate
  only after arriving at their final destination.
• Selection hypothesis
• NC cells are determined before they migrate.
• Cells that reach the appropriate final
  destination survive

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Differentiation of Neural Crest

• Determined mostly by their final location
• Migrate as undetermined cells and differentiate
  only after arriving at their final destination.

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Experiment showing NC cells are determined
mostly by their final location
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06_09a
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06_09b