Cokelets Axiom: You have to take thermodynamics three times to understand it' The first time you are

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Some Closing Thoughts

• Cokelets Axiom You have to take
  thermodynamics three times to understand it. The
  first time you are just plugging numbers into
  equations. The second time you are totally
  confused, but by the third time you begin to
  understand it.
• Dr. Giles Cokelet
• (my thermo professor)

Raphaels Corollary To really begin to
understand thermodynamics, you have to teach it.
?s Corollary ????
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Well, maybe we can understand by some analogies .

• THE LAWS OF THERMODYNAMICS for Sanitation
  Engineers
• 0th There is s.
• 1st You can't get rid of it.
• 2nd It gets deeper.
• 3rd A nice, empty trashcan is wishful thinking.
• KEEP SHOVELING!!

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Three Laws of Thermodynamics (paraphrased)

• First Law You can't get anything without
  working for it.
• Second Law The most you can accomplish by work
  is to break even.
• Third Law You can't break even.

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Ginsberg's Theorem 1. You can't win. 2. You
can't even break even 3. You can't get out of
the game

• Freeman's Commentary on Ginsberg's Theorem
  "Every major philosophy that attempts to make
  life seem meaningful is based on the negation of
  one part of Ginsberg's Theorem.
• 1. Capitalism is based on the assumption that
  you can win.
• 2. Socialism is based on the assumption that
  you can break even.
• 3. Mysticism is based on the assumption that
  you can quit the game.

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Thermodynamics in Biology

• Biological systems obey the laws of physical and
  chemistry
• We now have an enormous amount of information on
  events that take place in living cells at the
  molecular level
• - But most of this is qualitative and
  descriptive
• Often, we know which phenomena take place, but we
  dont know why things happen the way they do

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• Thermodynamics will tell you why and under
  what conditions
• Some biological questions
• Why do rafts form in membranes ?
• Why do cells adhere to each other ?
• Why do proteins fold?
• Thermodynamics provides an approach for
  understanding the driving forces responsible for
  many other biological processes and for
  rationalizing the observed pathways. Once we
  understand biological events, we can learn to
  control them and alter them
• - correcting mis-folding of proteins
• - controlling adhesion so as increase resistance
  to viral infections

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What my goals have been

• To give you an appreciation (if not a love) for
  the subject of thermodynamics
• Appreciate it even if you cant love it
• To be mathematically rigorous
• so as to better prepare you for your future life
• To teach you to think outside the box
• so that one of you may find a cure for heart
  disease, cancer, etc.
• We have covered a lot, but youve actually
  learned more than you think you have learned

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Recall from the First Lecture

• "A theory is the more impressive the greater the
  simplicity of its premises, the more different
  kinds of things it relates, and the more extended
  its area of applicability. Hence the deep
  impression that classical thermodynamics made
  upon me. It is the only physical theory of
  universal content concerning which I am convinced
  that within the framework of applicability of its
  basic concepts, will never be overthrown.
• --- Albert Einstein