Autologous skeletal myoblast for myocardial repair

1
Autologous skeletal myoblast for myocardial repair

• Felipe Prósper
• Clínica Universitaria

2
Patient characteristics

• Patients
• n 12
• Age 40 71 yo (59.2)
• LVEF 0.20 0.45 (35)
• Surgery
• Grafts 2.2/pat
• Cell therapy
• Biopsy 9.45 gr (5.5-14 gr)
• Myoblast 221 (105-390 x 106)
• Purity (CD56/CD45-) 67

3
Myoblast transplant was not associated with
increased incidence of cardiac arrythmias
4
 
CABG and Myoblast transplant was associated with
increased LVEF
12 months
6 months
3 months
Baseline
554.9
534.9
513.6
372.3
2D
563.9
563.1
513.9
383.26
ABD
5
CABG and myoblast treatment was associated with
improvement in the WMSI
Global
Treated Segments
6
CABG and myoblast treatment was associated with
increased uptake of 18F FDG and 13N Ammonia
FDG PET (Global)
Ammonia PET (Global)
plt0.01
plt0.01
Ammonia PET (Treated)
FDG PET (Treated)
plt0.01
plt0.01
7
18F FDG PET
Baseline
3 months
Baseline
3 months
Myoblasts
No Myoblasts