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Apresentao do PowerPoint

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Malaria and Dengue. A mosquito-based approach. Design anti-pathogen genes ... Specie-specific markers. Dr. Margareth L. Capurro. ICB USP. Bianca Burini ... – PowerPoint PPT presentation

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Title: Apresentao do PowerPoint


1
Malaria and Dengue A mosquito-based approach
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  • Design anti-pathogen genes
  • Mosquito Population

4
Culex quinquefasciatus
West Nile fever
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An. darlingi
An. aquasalis
Malaria
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Ae. aegypti Ae. albopictus
Dengue fever
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Anti-pathogen genes
  • Recombinant antibodies
  • (scFv - single chain antibody)
  • Active peptides
  • Protein domains

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  • Recombinant antibodies
  • (scFv - single chain antibody)

1A10-2 1B7 E protein 3H5 9A3D-8 2H2
prM
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1A10-2-scFv
Sindbis expression system
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pBac3xP3-EGFP, Vg-effector
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Plasmodium gallinaceum and Aedes aegypti
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Transgene
Effectors Molecules
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Aedes aegypti fat body transcriptome
50.82
30.05
5.16
7.97
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Macro array
?
?
130 transcripts
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Proteomic approach on hemolymph proteins
?
BF
Sucrose
24 hs
OV
48 hs
72 hs
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14
6
18
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1
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5
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Non-infected P.gal infected
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Mosquitoes Population
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José Eduardo Bracco e Dr. Maria Anice Sallun
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3
23
5
2
9
7
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Uganda, Singapore, Cambodia and Tahiti
Senegal
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18
The haplotype network for mitochondrial ND4 from
Aedes aegypti populations from Brazil. Each line
in the network represents a single mutational
change. White circle represents a theoretical
interior node.
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Ae. albopictus
Ae. aegypti
Specie-specific markers
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  • Dr. José Eduardo Levi
  • IMT - USP

Dr. Margareth L. Capurro ICB USP Bianca
Burini Fernanda Rosa MT - FAPESP Ricardo V.
Araújo DD - CNPq Fabiana M. Feitosa DD -
FAPESP JoãoV. Camargo e Silva DD -
CAPES Daniela G. Rodrigues MT - CNPq Ceres M.
de Miranda MT - CNPq Márcia Sperança PosDoc -
FAPEMA José Eduardo Bracco DT-
(SUCEN) Alexandre Moura technical support
  • Dr. Anthony A. James
  • UCI
  • Dr. Ken Olson
  • Colorado State
  • Dr. Maria Anice Sallun
  • FSP - USP
  • Dr. Tania Bijovsky
  • ICB - USP

Supported by FAPESP
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