Albert Sabin 19061993

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Albert Sabin (1906-1993)
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Hand-Foot-and-Mouth Disease
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Foot-and-Mouth Disease
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Genome and polyprotein of Picornaviridae
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Viral proteins

• Structural proteins are the proteins that are
  found in the virion ( the viral particle)
• Non structural proteins are proteins encoded by
  the viral genome but which are not part of the
  virions

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Nucleus
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Poliovirus receptor binds to the virions via the
canyons which are protected from the host immune
system.
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WIN-like drugs are canyon blockers that showed
some promise. Problem is delivery, solubility,
and getting high enough concentrations to the
affected site. Eg. Pleconaril was going to cure
the common cold.
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Genome and polyprotein of Picornaviridae
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Initiation of translation of a capped mRNA
(simplified)
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Translation begins with internal initiation at
IRES
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Genome and polyprotein of Picornaviridae
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