Comparing the Action of Valium and Anectine on the Somatic Motor Pathway.

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Comparing the Action of Valium and Anectine on
the Somatic Motor Pathway.
Jodi Lucas, Brook Hinckle, Amanda Markell, and
Jen Byrne
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Valium (Diazepam)

• Uses
• Anxiety
• Alcohol Withdrawal
• Controls Epilepsy
• Relief of Muscle Spasms
• Effective Sedation

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Mechanisms of Action

• Binds to stereospecific benzodiazapine receptors
  on the postsynaptic GABA neuron at several sites
  within the CNS, including the brain stem, and
  reticular formation.
• Enhancement of the inhibitory effect of GABA on
  neuronal excitability results, by increased
  neuronal membrane permeability to chloride ions.
  This shift in chloride ions results in
  hyperpolarization and stabilization of the cell.

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Anectine (Succinylcholine chloride)

• Uses
• Muscle relaxation/Paralysis
• Suppression of the twitch response
• Facilitation of ET intubation (control of
  breathing during mechanical ventilation)

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Mechanisms of Action

• Imitates the action of Ach producing
  depolarization of the motor end-plate at the
  myoneural junction, which causes sustained
  flaccid skeletal muscle paralysis.
• Initially excites skeletal muscle by binding to
  nicotinic receptors then prevents contraction by
  prolonging the time during which the receptors at
  the neuromuscular junction cannot respond to Ach.

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Comparison

• Both Valium and Anectine act on muscle cells.
• Valium depresses the CNS whereas Anectine acts at
  the Neuromuscular junction, specifically at
  nicotinic receptors.
• Valium has a long term effect and is used to
  treat multiple conditions. It is also a graded
  response and doesnt interfere with other muscle
  functions. Anectine has the fastest onset of
  action of all muscle relaxants but the effect is
  only in the range of a few minutes. Anectine also
  has a paralyzing effect on all skeletal muscles
  and is not graded.

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• Because Valium is a CNS depressant it can effect
  your consciousness level, whereas Anectine has no
  effect on consciousness.

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Analogy