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Linkage Studies 1a

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Power of 595 independent sib pairs (Koller et al. 2000) and 53 pedigrees ... QTLs for Animal Models with Putative Homologous Human Location ... – PowerPoint PPT presentation

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Title: Linkage Studies 1a


1
Linkage Studies (1a)
2
Linkage Studies (1b)
3
Power of 595 independent sib pairs (Koller et al.
2000) and 53 pedigrees composed of 630
individuals (Deng et al. 2002).
A recombination fraction0
B recombination fraction0.05.
4
Linkage Studies (2)
5
Linkage Studies (3)
6
Linkage Studies (4)
7
Linkage Studies (5)
8
Sib pairs Required to Achieve 80 Power (at LOD
3.0)
Comments
9
QTL Mapping in Mice
10
QTLs for Animal Models with Putative Homologous
Human Location
11
QTLs for Animal Models with Putative Homologous
Human Location
12
QTLs for Animal Models with Putative Homologous
Human Location
13
QTLs for Animal Models with Putative Homologous
Human Location
14
Fine Mapping (30cM to 1 cM) (Deng et al. 2000)
Exclusion Mapping (Deng et al., 2001)
15
What phenotypes to study?
16
Correlations between two complex traits
17
Limitation of studying risk factors only (1)
  • NIDDM (Ghosh et al. 2000) chromosomes 20, 11, 2,
    10 and 6.
  • Risk factors (Watanabe et al. 2000) chromosomes
    3 (fasting C-peptide/glucose), 10 (acute insulin
    response), 13 (BMI and 2-h insulin), 17 and 19
    (empirical insulin-resistance index).

18
Limitation of studying risk factors only (2)
  • Myocardial infarction
    (Broeckel et al., 2002) Chromosome 14.
  • Risk factors (Broeckel et al., 2002) Chromosomes
    1 and 6 (lipoprotein a), 14,17 (LDL cholesterol
    concentrations), 1 (HDL cholesterol
    concentrations) , 9 (triglyceride concentration),
    6 (type II diabetes), 6 (systolic hypertention),
    1 (diastolic hypertention).

19
DNA microarray studies
20
DNA microarray studies Examples
  • Identification of 9 novel genes and ESTs induced
    in murine osteoblasts during their
    differentiation from mesenchymal progenitor cells
    (Vaes et al., 2002).

21
Proteomics
  • 30,000 genes, 1.5 million proteins.
  • Analyzing functions of gene products (large-scale
    identifying or localizing proteins and studies of
    protein-protein interactions).
  • Linking gene expression to cell metabolism and
    function and to genetic maps.

22
Acknowledgement
23
Thank you!
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