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Genomics and Proteomics

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Genomics and Proteomics. Chapter 20. Genome Sequencing Strategies. ORF Analysis of DNA Sequences ... Note the number/percentage of genes in the final two ... – PowerPoint PPT presentation

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Title: Genomics and Proteomics


1
Genomics and Proteomics
  • Chapter 20

2
Genome Sequencing Strategies
3
ORF Analysis of DNA Sequences
4
Analysis of Human DNA Sequence
5
Genomics
6
P. aeruginosa Genome
  • Note the number/percentage of genes in the final
    two categories

7
Gene Class Assignment
8
Prokaryotic Genome Comparisons
9
Prokaryotic Genome Organization
  • Note that not all bacteria have single circular
    chromosomes
  • Some have two and they may be linear
  • And even plasmids follow the multiple and may be
    linear pattern

10
Vibrio cholerae Genome
  • Two circular chromosomes of about 1 and 3 million
    base pairs

11
E. coli Gene Organization
  • Eubacterial genomes are about 85-90 codingcode
    for genes/RNAs
  • Introns rare
  • 100-125 bp between genes common
  • Many genes in operons
  • E. coli has 600 operons

12
Aquifex aeolicus Operon Organization
  • Not all encoded products of all operons have
    related functions or are components of a single
    pathway/structure
  • Shown above
  • Two for DNA recombination, one for lipid
    biosynthesis, one for nucleic acid biosynthesis,
    on for protein synthesis and one for cell motility

13
Genome Size vs. Gene Number
14
Gene Densities
15
Two Dimensional Gel Electrophoresis
16
2D Analysis
  • Several thousand proteins can be resolved by this
    procedure

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