varicella zoster virus

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varicella zoster virus

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• G46640553

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Herpesviruses

• Herpesviruses include
• herpes simplex virus (types 1 and 2)
• cytomegalovirus
• varicella zoster virus

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varicella zoster virus

• Virus Species human herpesvirus
  3(varizella-zoster)
• Virus Genus Varicellovirus
• Virus Family Herpesviridae
• Virus Subfamily Alphaherpesvirinae
• Host Homo sapiens

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varicella zoster virus
http//web.uct.ac.za/depts/mmi/stannard/cpeherps.h
tml

• The bar represents 100 nm.Naked capsids

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varicella zoster virus

• (VZV) establishes a latent infection in sensory
  ganglia. Reactivation usually occurs many years
  after primary infection and is often associated
  with immunosuppresion of the host

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http//web.uct.ac.za/depts/mmi/jmoodie/vzv2.html
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• The virus travels down the axon and re-infects
  the dematome supplied by the sensory ganglian to
  produce painful vesicles on the skin.
• Common sites include the thoracic dermatomes and
  those supplied by the trigeminal nerve.
• Post herpetic neuralgia is a common complication

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• Varicella zoster virus will replicate in either
  epithelial cells (as shown here) or fibroblasts.

http//web.uct.ac.za/depts/mmi/stannard/cpeherps.h
tml
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• (1) turns into blisters (2) that resemble
  chickenpox lesions. The blisters fill with pus,
  break open (3), crust over (4), and finally
  disappear
• (5) damage to the nerves

• http//www.fda.gov/fdac/features/2001/301_pox.html

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www.emedicine.com/ OPH/topic257.htm
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• Invasion of the 8th nerve ganglia and the
  geniculate ganglion of the facial nerve by the
  herpes zoster virus, producing severe ear pain,
  hearing loss, vertigo, and paralysis of the
  facial nerve

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Referrences

• http//web.uct.ac.za/depts/mmi/stannard/cpeherps.h
  tml
• http//www.fda.gov/fdac/features/2001/301_pox.html
  
• http//www.merck.com/mrkshared/mmanual/section7/ch
  apter85/85e.jsp