Compare and contrast pharmacogenetics and pharmacogenomics ... Patient buccal swab (sample) SNP Screening. Results. Results. Analysis. Data Management: ...
Causes:excessive smoking, caffeine, or alcohol use; digitalis toxicity,and so on. It occurs ... digitalis 2. blood thinners, such as heparin or Warfarine, ...
The Pharmacogenetics of Warfarin: Assessing quality of studies in ... many smaller, some severely underpowered studies advised ... Underpowered studies with ...
Title: PowerPoint Presentation Author: Peter Loewen Last modified by: Tim Rogers Created Date: 9/29/2006 3:43:35 PM Document presentation format: On-screen Show
Monitoring Drug Efficacy & Toxicity - along with drug metabolism Michael E. Hodsdon, MD, PhD Associate Professor Departments of Laboratory Medicine & Pharmacology
... With Data Suggesting Efficacy Safe Herbals With Data Suggesting Efficacy Co-Enzyme Q-may decrease INR while on warfarin Chamomile-may increase INR if on ...
... Emergencies causing the blood to be dark brown in color Toxicologic Emergencies Metals Lead toxicity more common in dogs ... Acute renal failure ...
ACC/AHA/ESC AF Guidelines (1) Author: Information Systems Last modified by: ... Control to Prevent Stroke in AF* Efficacy of Anticoagulation for AF Warfarin for AF: ...
Drug Biotransformation Elimination of the drugs Drug Biotransformation Metabolism or biotransformation - complex of processes which provide decreasing of toxicity and ...
Readily exreted by the kidney when surpassing the renal threshold - toxicity is rare ... hypercalcemia with hypercalciuria (!stones), bone demineralization. Vitamin E ...
Prescription Drug Use Among Community ... Consumption of 'high risk' drugs: e.g., warfarin, digoxin, cimetidine, phenytoin, ... Anticholinergic drugs and BPH ...
nothing unique about 'toxic' chemicals. Illustrations: Hormone mimics. Bioremediation ... Can increase or reduce toxicity by supplementing or removing toxic form ...
Urinary Retention. prolonged use of an indwelling urinary ... Treatable causes. hypoxia, infection, fluid and electrolyte abnormalities, drug toxicity, and ...
Repeating polymer of uronic acid and glucosamine. Highly heterogeneous in terms of sulfation and ... Warfarin-induced Venous Limb Gangrene. in HIT Patients ...
... Arixtra (fondaparinux); Fragmin (dalteparin) Typically used post-operatively and short-term Must have stop date PO Coumadin (warfarin, jantoven); ...
1. Short Acting Warfarin. 2. Long Acting---Diphacenone, ... and progressive ataxia, paresis, hind leg paralysis, progressive CNS depression and coma. ...
SOME FACTS AND STATISTICS. Factors to drug responses: ... Linder MW Ph.D. DABCC, Manage the 'Over-steer' in warfarin dose titration. VKORC1 POLYMORPHISM ...
used for control of various pests. General Considerations. Substances used to kill unwanted 'pests' Algae-, herb-, insect-, rodent- Selective toxicities ...
Posterior fossa surgery. Aspirin. Warfarin. Closure. PFO WITH LARGE SHUNT (shower or curtain) ... Fossa ovalis diameter. PFO tunnel. Rims: SA, IP, SP & IA rim ...
The RE-LY Study: Randomized Evaluation of Long-term anticoagulant therapY Dabigatran Compared to Warfarin in 18,113 Patients with Atrial Fibrillation at Risk of Stroke
'An antagonist is a substance that does not provoke a biological response itself, ... Example: phenobarbital accelerates the rate of metabolic degradation of warfarin ...
Previous induction of antibodies (100 d) Rare. Heparin absent ... (2) administering IV vitamin K to patients on warfarin. Efficacy of Direct Thrombin Inhibitors ...
After one week , the patient accidently but lightly bumped her arm on the side ... After investigation ,the physcian discovered that this herbal coktail ...
* Figure 2. Percentage of Patients with Dose Estimates within 20% of the Actual Dose, as Derived with the Use of a Pharmacogenetic Algorithm, a Clinical Algorithm ...
Antimicrobial Agents (Aminoglycosides, tetracyclines, macrolides and other assorted drugs) Dr. Jeff Hobden MIP The Aminoglycosides Two or more amino sugars attached ...
Small separation between dose-response curves for preventing emboli and excess coagulation ... Elderly woman in nursing home -Sent to ER with lower GI bleed -Dx ...
Chapter 16 NSAIDs and COX-2-Selective Inhibitors Jeffrey A. Katz, M.D. R2 Lee Seung Il Mechanism of Action Prostaglandin Physiology Hyperalgesia (1) sensitize ...
Historical Development of Toxicology It is one of the oldest practical sciences which began with early cave dwellers who recognized poisonous plants and animals and ...
drug clearance mechanisms (renal and hepatic) are limited in newborns ... reduced hepatic blood flow. reduced activities of cytochrome P450 enzymes. gender ...
Heparin first used in vascular surgery 1930's. LMWH approved ... agent for LMWH for prophylaxis or initial treatment of venous thromboembolism. Treatment of HIT ...
Assessment of Efficacy and Safety for Exanta (Ximelagatran) Ruyi He, M.D. Medical Team Leader The Division of Gastrointestinal and Coagulation Drug Products
Milk thistle St John's wort (Silibinin) Garlic. Peppermint oil (Menthol) ... St John's wort may significantly reduce the effectiveness of the following by ...