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aromatic, aliphatic, nitrogen. dealkylations(N-, S-, P) deaminations. N-, S-, P- oxidations ... aliphatic. aromatic. aliphatic. BIOTRANSFORMATION - NONSYNTHETIC ...
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Chapter 9 Biotransformation Biotransformation The term biotransformation is the sum of all chemical processes of the body that modify endogenous or exogenous chemicals.
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Drug Biotransformation Elimination of the drugs Drug Biotransformation Metabolism or biotransformation - complex of processes which provide decreasing of toxicity and ...
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Aliphatic hydroxylation. Aliphatic epoxidation. Heteroatom ... Sulfate group added to hydroxyl groups present on phenols or aliphatic alcohols. Enzyme: ...
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All organisms are exposed constantly and unavoidably to foreign chemicals or ... Example: Benzo[a]pyrene undergoes a series of metabolic reactions producing a ...
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Biotransformation of Toxicants Lect 6 Metabolism (Biotransformation) Many xenobiotics undergo chemical transformation (biotransformation; metabolism ...
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The most likely absorption modes parallel the normal processes of ... Sulphation: addition of a sulphate moiety. CYP 450. OH. Benzene Phenol Phenyl Sulfate ...
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Drug Elimination Biotransformation Hepatic, Renal, Pulmonary Secretion of unchanged drug Renal, biliary (hepatic), GI, mammary, salivary Drug Elimination ...
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Prodrugs and Drug Delivery Systems. Prodrug - a pharmacologically inactive compound that is converted to an active drug by a metabolic biotransformation
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Biotransformation refers to a biological process where the end ... Fortuitous transformation of a compound by a microbe relying on some other primary substrate ...
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Toxicity results from a sequence of events that can be characterized ... Concomitant xenobiotic exposures. Induction / inhibition of biotransformation enzymes ...
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Chapter 13. Drug Metabolism Introduction: the process of drugs in the body includes absorption, distribution, metabolism and elimination. Drug metabolism is also ...
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FARMAKOLOGI BEBAN STUDI = 3 SKS ... Hormon & Uterotonika ... To know drug effect To know drug Interaction To know spectrum drug respons MECHANISM OF ACTION : ...
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These enzymes metabolize drugs only because the drugs resemble the natural compound ... SSRI antidepressants) Drug Metabolism - Reduction Azo-reduction: Nitro ...
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... pathways for the metabolism of 3,3',4,4'-TCB in beluga whale liver microsomes. ... PCB and DDE metabolites in beluga whale (Delphinapterus leucas) from the St. ...
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The Organic Chemistry of Drug Design and Drug Action Chapter 7 Drug Metabolism Glutathione Conjugation Scheme 7.50 Further Metabolism of GSH Conjugates Metabolism of ...
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Laboratory Markers of Toxins and Detoxification Dr. Eve Bralley and Dr. Elizabeth Redmond * * * * * Elements Erythrocytes/Whole Blood OrganixSM Profile Case 4 41 year ...
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POLYPHARMACY Pio L. Oliverio, MD Fellow, Geriatrics SVCMC, Jamaica, NY February 27, 2006 Definition POLYPHARMACY Use of several drugs or medicines together in the ...
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... family of enzymes Metabolizes a broad range of structurally diverse endogenous and exogenous compounds Structurally related family ... Taxol (cancer drug ...
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PHARMACOLOGY 1391 Studies the effects of drugs and how they exert their effects. acetylsalicylic acid (ASA) reduce inflammation, pain and fever inhibit the action of ...
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... Pharmacokinetics body drug - drug-concentration relationship 4 processes: A. absorption rate circulating fluids factors: drug ...
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Low pressure veins in esophagus, anterior abdominal wall, splenic veins, rectum. Esophageal and gastric varices, ascites, hemorrhoids, splenic enlargement ...
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Drugs tend to bind to tissues, usually protein molecules ... more toxic (mutagenic, teratogenic etc.) Drugs with Active Metabolites. Types of Metabolism ...
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The key to creating personalised drugs with greater efficacy and safety ... drug molecule with a polar moiety such as glucuronate, sulfate, acete, ...
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PERINATAL AND PEDIATRIC PHARMACOLOGY Dr. Manuel E. Valdez Department of Pediatrics UPHRMC Aspects of Drug Therapy During Pregnancy access of the drugs to the fetus ...
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DISTRIBUTION METABOLISM EXCRETION ABSORPTION Metabolism Polymorphisms Influencing Drug Responses (continued) GENE PRODUCT RESPONSES AFFECTED (GENE) Glutathione ...
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Environmental Toxicology. Toxicants in Living Organisms ... Ex: aspirin acidic, but neutral in stomach. Must be soluble in body/cell fluids for abs'n ...
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Pharmokinetics - Pharmacodynamics CHAPTER 3 - 4 Dr. Dipa Brahmbhatt VMD MpH dbrahmbhatt@vettechinstitute.edu
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Metabolic Changes of Drugs Books: 1. Wilson and Gisvold s Textbook of Organic Medicinal and Pharmaceutical Chemistry 11th ed. Lippincott, Williams & Wilkins ed.
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Kidney is the major organ of drug elimination from the human body ... TDF. Blood. Lumen. OAT1. MRP. Proximal. Tubule. Toxicology ...
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Tuberculosis Trials Consortium Pharmacology Studies and Capacity. Marc Weiner, M.D. ... Health Science Center at San Antonio. 29a- Interaction high dose RPT on ...
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METABOLIC CHANGES OF DRUGS AND RELATED ORGANIC COMPOUNDS Chapter 2 Roselyn Aperocho-Naranjo USPF-College of Pharmacy rose_may26@yahoo.com www.roselynnaranjo.vze.com
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Biochemistry in Liver (heterogeneity) ...
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Biochemistry in Liver (heterogeneity) ...
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The biogeochemistry of Pu mobilization and retention B.D. Honeyman (PI)1, A.J. Francis2, C. J. Dodge2, J.B. Gillow2 and P.H. Santschi3 1Environmental Science and ...
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fortuitous transformation of a compound by a microbe relying on some other primary substrate ... microbes are adjusting to the new substrate (food source) ...
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Metabolism of xenobiotics Vladim ra Kvasnicov XENOBIOTICS = compounds foreign to the body ENTRANCE TO THE BODY digestive tract blood LIVER lungs blood ...
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Write a 1-2 page evaluation of the product. Include discussion of how it might ... animals, reptiles, insects, abrasions, puncture wounds, cuts, needle sticks ...
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7. TOXIC ORGANIC CHEMICALS If we live as if it matters and it doesn't master, it doesn't matter. If we live as if it doesn't matter, and it matters, then it matters.
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Distribution of toxicants in the body Lymphatic system Lymph capillaries, nodes, tonsils, spleen, thymus, ... Heavy metals, like Pb Storage in liver.
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Chrysanthemum parthenium (L.) Berhn (feverfew) , Aristolochia fangchi ( ) as anti-inflammatory, contains aristolochic acid (AA ...
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Pharmacokinetic drug interactions are dealt in this presentation.
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4. Describe how drugs are removed from the body. ... definition of prodrug an inactive form of a drug that is converted to active form in the body. ...
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... available on the production levels since its ban in the United states after 1982. ... effects on human life is essential to impose a ban on the chemical. ...
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CIVE 7332 Lecture 4b Fate and Transport Advection and Dispersion Covered in Days 1, 2 Sorption and Retardation Chemical/Abiotic processes Volatilization ...
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Acute response: rash, watering eyes, cough from brief exposure to ammonia ... Many chemicals are either soluble in water or in oil (fat, lipid) ...
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(e.g. heparan sulfate, chondroitin sulfate), sulfated ... FAD. FMN. Heme (Fe) NADPH H NADP 2H 2 e- 2 e- 2 e- O2. R-H. O2- R-OH. Cytochrome P450 ...
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Toxicity and Human Health Inneke Hantoro Toxicity Toxicity is the potential of a chemical to induce an adverse effect in a living organism e.g., man.
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Title: Definition of Natural Attenuation Author... Last modified by: Hanadi Rifai Created Date: 4/12/1999 10:50:22 AM Document presentation format
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Flore microbienne tr s importante au niveau du rumen. ... R le d toxifiant de la population microbienne. paroi k ratinis e: limite l'absorption les mycotoxines dans le sang. ...
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(PRICE LOWERED) Seriously the Easiest Way to Learn Pharmacology
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Title: A novel mechanism for oral controlled release of drugs by continuous degradation of a phospholipid prodrug along the intestine: In-vivo and in-vitro evaluation ...
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Engineered system to increase the intrinsic biodegradation rate to reduce ... Laboratory or small-scale field studies required to determine if particular ...
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Title: Management of Acetaminophen Toxicity Author: Mark Ryan Last modified by: SACTRC Created Date: 3/13/1997 6:52:28 PM Document presentation format
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Hyperbaric oxygen therapy using 1-1,5 ATM for 60 min. 2 ... Clinic with milder forms is fully consistent with allergic reactions from mild intensity to ...
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Control of landfill leachates contaminated groundwater by a MULTIBARRIER approach
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