109 Sulfation Biotransformation PPTs View free & download

BIOTRANSFORMATION PowerPoint PPT Presentation

BIOTRANSFORMATION - aromatic, aliphatic, nitrogen. dealkylations(N-, S-, P) deaminations. N-, S-, P- oxidations ... aliphatic. aromatic. aliphatic. BIOTRANSFORMATION - NONSYNTHETIC ...

aromatic, aliphatic, nitrogen. dealkylations(N-, S-, P) deaminations. N-, S-, P- oxidations ... aliphatic. aromatic. aliphatic. BIOTRANSFORMATION - NONSYNTHETIC ...

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Biotransformation - Chapter 9 Biotransformation Biotransformation The term biotransformation is the sum of all chemical processes of the body that modify endogenous or exogenous chemicals.

Chapter 9 Biotransformation Biotransformation The term biotransformation is the sum of all chemical processes of the body that modify endogenous or exogenous chemicals.

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Drug Biotransformation PowerPoint PPT Presentation

Drug Biotransformation - Drug Biotransformation Elimination of the drugs Drug Biotransformation Metabolism or biotransformation - complex of processes which provide decreasing of toxicity and ...

Drug Biotransformation Elimination of the drugs Drug Biotransformation Metabolism or biotransformation - complex of processes which provide decreasing of toxicity and ...

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Biotransformation - Aliphatic hydroxylation. Aliphatic epoxidation. Heteroatom ... Sulfate group added to hydroxyl groups present on phenols or aliphatic alcohols. Enzyme: ...

Aliphatic hydroxylation. Aliphatic epoxidation. Heteroatom ... Sulfate group added to hydroxyl groups present on phenols or aliphatic alcohols. Enzyme: ...

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Biotransformation of Toxicants PowerPoint PPT Presentation

Biotransformation of Toxicants - All organisms are exposed constantly and unavoidably to foreign chemicals or ... Example: Benzo[a]pyrene undergoes a series of metabolic reactions producing a ...

All organisms are exposed constantly and unavoidably to foreign chemicals or ... Example: Benzo[a]pyrene undergoes a series of metabolic reactions producing a ...

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Biotransformation of Toxicants - Biotransformation of Toxicants Lect 6 Metabolism (Biotransformation) Many xenobiotics undergo chemical transformation (biotransformation; metabolism ...

Biotransformation of Toxicants Lect 6 Metabolism (Biotransformation) Many xenobiotics undergo chemical transformation (biotransformation; metabolism ...

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Absorption, distribution, excretion and biotransformation of contaminants in living organisms PowerPoint PPT Presentation

Absorption, distribution, excretion and biotransformation of contaminants in living organisms - The most likely absorption modes parallel the normal processes of ... Sulphation: addition of a sulphate moiety. CYP 450. OH. Benzene Phenol Phenyl Sulfate ...

The most likely absorption modes parallel the normal processes of ... Sulphation: addition of a sulphate moiety. CYP 450. OH. Benzene Phenol Phenyl Sulfate ...

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Drug Elimination PowerPoint PPT Presentation

Drug Elimination - Drug Elimination Biotransformation Hepatic, Renal, Pulmonary Secretion of unchanged drug Renal, biliary (hepatic), GI, mammary, salivary Drug Elimination ...

Drug Elimination Biotransformation Hepatic, Renal, Pulmonary Secretion of unchanged drug Renal, biliary (hepatic), GI, mammary, salivary Drug Elimination ...

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The Organic Chemistry of Drug Design and Drug Action PowerPoint PPT Presentation

The Organic Chemistry of Drug Design and Drug Action - Prodrugs and Drug Delivery Systems. Prodrug - a pharmacologically inactive compound that is converted to an active drug by a metabolic biotransformation

Prodrugs and Drug Delivery Systems. Prodrug - a pharmacologically inactive compound that is converted to an active drug by a metabolic biotransformation

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AEROBIC AND ANAEROBIC BIODEGRADATION PowerPoint PPT Presentation

AEROBIC AND ANAEROBIC BIODEGRADATION - Biotransformation refers to a biological process where the end ... Fortuitous transformation of a compound by a microbe relying on some other primary substrate ...

Biotransformation refers to a biological process where the end ... Fortuitous transformation of a compound by a microbe relying on some other primary substrate ...

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Principles of Toxicology Applications to Carcinogenesis PowerPoint PPT Presentation

Principles of Toxicology Applications to Carcinogenesis - Toxicity results from a sequence of events that can be characterized ... Concomitant xenobiotic exposures. Induction / inhibition of biotransformation enzymes ...

Toxicity results from a sequence of events that can be characterized ... Concomitant xenobiotic exposures. Induction / inhibition of biotransformation enzymes ...

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Chapter 13. Drug Metabolism PowerPoint PPT Presentation

Chapter 13. Drug Metabolism - Chapter 13. Drug Metabolism Introduction: the process of drugs in the body includes absorption, distribution, metabolism and elimination. Drug metabolism is also ...

Chapter 13. Drug Metabolism Introduction: the process of drugs in the body includes absorption, distribution, metabolism and elimination. Drug metabolism is also ...

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FARMAKOLOGI - FARMAKOLOGI BEBAN STUDI = 3 SKS ... Hormon & Uterotonika ... To know drug effect To know drug Interaction To know spectrum drug respons MECHANISM OF ACTION : ...

FARMAKOLOGI BEBAN STUDI = 3 SKS ... Hormon & Uterotonika ... To know drug effect To know drug Interaction To know spectrum drug respons MECHANISM OF ACTION : ...

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Drug Metabolism PowerPoint PPT Presentation

Drug Metabolism - These enzymes metabolize drugs only because the drugs resemble the natural compound ... SSRI antidepressants) Drug Metabolism - Reduction Azo-reduction: Nitro ...

These enzymes metabolize drugs only because the drugs resemble the natural compound ... SSRI antidepressants) Drug Metabolism - Reduction Azo-reduction: Nitro ...

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Environmental Toxicology PowerPoint PPT Presentation

Environmental Toxicology - Title: Environmental Toxicology Author: Preferred Customer Last modified by: agrippo Created Date: 9/20/2004 1:22:59 AM Document presentation format

Title: Environmental Toxicology Author: Preferred Customer Last modified by: agrippo Created Date: 9/20/2004 1:22:59 AM Document presentation format

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The Aryl hydrocarbon (Ah) Receptor: Comparative Toxicology and Possible Role as a Biomarker of Dioxin Susceptibility PowerPoint PPT Presentation

The Aryl hydrocarbon (Ah) Receptor: Comparative Toxicology and Possible Role as a Biomarker of Dioxin Susceptibility - ... pathways for the metabolism of 3,3',4,4'-TCB in beluga whale liver microsomes. ... PCB and DDE metabolites in beluga whale (Delphinapterus leucas) from the St. ...

... pathways for the metabolism of 3,3',4,4'-TCB in beluga whale liver microsomes. ... PCB and DDE metabolites in beluga whale (Delphinapterus leucas) from the St. ...

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The Organic Chemistry of Drug Design and Drug Action - The Organic Chemistry of Drug Design and Drug Action Chapter 7 Drug Metabolism Glutathione Conjugation Scheme 7.50 Further Metabolism of GSH Conjugates Metabolism of ...

The Organic Chemistry of Drug Design and Drug Action Chapter 7 Drug Metabolism Glutathione Conjugation Scheme 7.50 Further Metabolism of GSH Conjugates Metabolism of ...

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Laboratory Markers of Toxins and Detoxification PowerPoint PPT Presentation

Laboratory Markers of Toxins and Detoxification - Laboratory Markers of Toxins and Detoxification Dr. Eve Bralley and Dr. Elizabeth Redmond * * * * * Elements Erythrocytes/Whole Blood OrganixSM Profile Case 4 41 year ...

Laboratory Markers of Toxins and Detoxification Dr. Eve Bralley and Dr. Elizabeth Redmond * * * * * Elements Erythrocytes/Whole Blood OrganixSM Profile Case 4 41 year ...

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POLYPHARMACY PowerPoint PPT Presentation

POLYPHARMACY - POLYPHARMACY Pio L. Oliverio, MD Fellow, Geriatrics SVCMC, Jamaica, NY February 27, 2006 Definition POLYPHARMACY Use of several drugs or medicines together in the ...

POLYPHARMACY Pio L. Oliverio, MD Fellow, Geriatrics SVCMC, Jamaica, NY February 27, 2006 Definition POLYPHARMACY Use of several drugs or medicines together in the ...

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Drug Metabolism - ... family of enzymes Metabolizes a broad range of structurally diverse endogenous and exogenous compounds Structurally related family ... Taxol (cancer drug ...

... family of enzymes Metabolizes a broad range of structurally diverse endogenous and exogenous compounds Structurally related family ... Taxol (cancer drug ...

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A PRIMER OF DRUG ACTION PowerPoint PPT Presentation

A PRIMER OF DRUG ACTION - PHARMACOLOGY 1391 Studies the effects of drugs and how they exert their effects. acetylsalicylic acid (ASA) reduce inflammation, pain and fever inhibit the action of ...

PHARMACOLOGY 1391 Studies the effects of drugs and how they exert their effects. acetylsalicylic acid (ASA) reduce inflammation, pain and fever inhibit the action of ...

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General Principles in Pharmacology PowerPoint PPT Presentation

General Principles in Pharmacology - ... Pharmacokinetics body drug - drug-concentration relationship 4 processes: A. absorption rate circulating fluids factors: drug ...

... Pharmacokinetics body drug - drug-concentration relationship 4 processes: A. absorption rate circulating fluids factors: drug ...

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Pharmacokinetic Changes in Hepatic Dysfunction PowerPoint PPT Presentation

Pharmacokinetic Changes in Hepatic Dysfunction - Low pressure veins in esophagus, anterior abdominal wall, splenic veins, rectum. Esophageal and gastric varices, ascites, hemorrhoids, splenic enlargement ...

Low pressure veins in esophagus, anterior abdominal wall, splenic veins, rectum. Esophageal and gastric varices, ascites, hemorrhoids, splenic enlargement ...

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Drug Handling in kidney and liver disease PowerPoint PPT Presentation

Drug Handling in kidney and liver disease - Drugs tend to bind to tissues, usually protein molecules ... more toxic (mutagenic, teratogenic etc.) Drugs with Active Metabolites. Types of Metabolism ...

Drugs tend to bind to tissues, usually protein molecules ... more toxic (mutagenic, teratogenic etc.) Drugs with Active Metabolites. Types of Metabolism ...

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Introduction to pharmacogenomics and personalised medicine PowerPoint PPT Presentation

Introduction to pharmacogenomics and personalised medicine - The key to creating personalised drugs with greater efficacy and safety ... drug molecule with a polar moiety such as glucuronate, sulfate, acete, ...

The key to creating personalised drugs with greater efficacy and safety ... drug molecule with a polar moiety such as glucuronate, sulfate, acete, ...

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PERINATAL AND PEDIATRIC PHARMACOLOGY PowerPoint PPT Presentation

PERINATAL AND PEDIATRIC PHARMACOLOGY - PERINATAL AND PEDIATRIC PHARMACOLOGY Dr. Manuel E. Valdez Department of Pediatrics UPHRMC Aspects of Drug Therapy During Pregnancy access of the drugs to the fetus ...

PERINATAL AND PEDIATRIC PHARMACOLOGY Dr. Manuel E. Valdez Department of Pediatrics UPHRMC Aspects of Drug Therapy During Pregnancy access of the drugs to the fetus ...

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EXCRETION - DISTRIBUTION METABOLISM EXCRETION ABSORPTION Metabolism Polymorphisms Influencing Drug Responses (continued) GENE PRODUCT RESPONSES AFFECTED (GENE) Glutathione ...

DISTRIBUTION METABOLISM EXCRETION ABSORPTION Metabolism Polymorphisms Influencing Drug Responses (continued) GENE PRODUCT RESPONSES AFFECTED (GENE) Glutathione ...

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Pharmokinetics - Pharmacodynamics PowerPoint PPT Presentation

Pharmokinetics - Pharmacodynamics - Pharmokinetics - Pharmacodynamics CHAPTER 3 - 4 Dr. Dipa Brahmbhatt VMD MpH dbrahmbhatt@vettechinstitute.edu

Pharmokinetics - Pharmacodynamics CHAPTER 3 - 4 Dr. Dipa Brahmbhatt VMD MpH dbrahmbhatt@vettechinstitute.edu

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Environmental Toxicology - Environmental Toxicology. Toxicants in Living Organisms ... Ex: aspirin acidic, but neutral in stomach. Must be soluble in body/cell fluids for abs'n ...

Environmental Toxicology. Toxicants in Living Organisms ... Ex: aspirin acidic, but neutral in stomach. Must be soluble in body/cell fluids for abs'n ...

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Metabolic Changes of Drugs PowerPoint PPT Presentation

Metabolic Changes of Drugs - Metabolic Changes of Drugs Books: 1. Wilson and Gisvold s Textbook of Organic Medicinal and Pharmaceutical Chemistry 11th ed. Lippincott, Williams & Wilkins ed.

Metabolic Changes of Drugs Books: 1. Wilson and Gisvold s Textbook of Organic Medicinal and Pharmaceutical Chemistry 11th ed. Lippincott, Williams & Wilkins ed.

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Chris Town - A Short Course in Pharmacokinetics Chris Town Research Pharmacokinetics Moving from Animals to Man Humans and model animals have different biochemistry, physiology ...

A Short Course in Pharmacokinetics Chris Town Research Pharmacokinetics Moving from Animals to Man Humans and model animals have different biochemistry, physiology ...

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Renal Disease and PKPD PowerPoint PPT Presentation

Renal Disease and PKPD - Kidney is the major organ of drug elimination from the human body ... TDF. Blood. Lumen. OAT1. MRP. Proximal. Tubule. Toxicology ...

Kidney is the major organ of drug elimination from the human body ... TDF. Blood. Lumen. OAT1. MRP. Proximal. Tubule. Toxicology ...

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METABOLIC CHANGES OF DRUGS AND RELATED ORGANIC COMPOUNDS PowerPoint PPT Presentation

METABOLIC CHANGES OF DRUGS AND RELATED ORGANIC COMPOUNDS - METABOLIC CHANGES OF DRUGS AND RELATED ORGANIC COMPOUNDS Chapter 2 Roselyn Aperocho-Naranjo USPF-College of Pharmacy rose_may26@yahoo.com www.roselynnaranjo.vze.com

METABOLIC CHANGES OF DRUGS AND RELATED ORGANIC COMPOUNDS Chapter 2 Roselyn Aperocho-Naranjo USPF-College of Pharmacy rose_may26@yahoo.com www.roselynnaranjo.vze.com

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Tuberculosis Trials Consortium Pharmacology Studies and Capacity PowerPoint PPT Presentation

Tuberculosis Trials Consortium Pharmacology Studies and Capacity - Tuberculosis Trials Consortium Pharmacology Studies and Capacity. Marc Weiner, M.D. ... Health Science Center at San Antonio. 29a- Interaction high dose RPT on ...

Tuberculosis Trials Consortium Pharmacology Studies and Capacity. Marc Weiner, M.D. ... Health Science Center at San Antonio. 29a- Interaction high dose RPT on ...

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Biochemistry in Liver PowerPoint PPT Presentation

Biochemistry in Liver - Biochemistry in Liver (heterogeneity) ...

Biochemistry in Liver (heterogeneity) ...

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Biochemistry in Liver - Biochemistry in Liver (heterogeneity) ...

Biochemistry in Liver (heterogeneity) ...

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The biogeochemistry of Pu mobilization and retention PowerPoint PPT Presentation

The biogeochemistry of Pu mobilization and retention - The biogeochemistry of Pu mobilization and retention B.D. Honeyman (PI)1, A.J. Francis2, C. J. Dodge2, J.B. Gillow2 and P.H. Santschi3 1Environmental Science and ...

The biogeochemistry of Pu mobilization and retention B.D. Honeyman (PI)1, A.J. Francis2, C. J. Dodge2, J.B. Gillow2 and P.H. Santschi3 1Environmental Science and ...

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Contaminant%20Fate%20and%20Transport%20Processes PowerPoint PPT Presentation

Contaminant%20Fate%20and%20Transport%20Processes - fortuitous transformation of a compound by a microbe relying on some other primary substrate ... microbes are adjusting to the new substrate (food source) ...

fortuitous transformation of a compound by a microbe relying on some other primary substrate ... microbes are adjusting to the new substrate (food source) ...

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Metabolism of xenobiotics PowerPoint PPT Presentation

Metabolism of xenobiotics - Metabolism of xenobiotics Vladim ra Kvasnicov XENOBIOTICS = compounds foreign to the body ENTRANCE TO THE BODY digestive tract blood LIVER lungs blood ...

Metabolism of xenobiotics Vladim ra Kvasnicov XENOBIOTICS = compounds foreign to the body ENTRANCE TO THE BODY digestive tract blood LIVER lungs blood ...

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7. TOXIC ORGANIC CHEMICALS PowerPoint PPT Presentation

7. TOXIC ORGANIC CHEMICALS - 7. TOXIC ORGANIC CHEMICALS If we live as if it matters and it doesn't master, it doesn't matter. If we live as if it doesn't matter, and it matters, then it matters.

7. TOXIC ORGANIC CHEMICALS If we live as if it matters and it doesn't master, it doesn't matter. If we live as if it doesn't matter, and it matters, then it matters.

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Industrial Toxicology PowerPoint PPT Presentation

Industrial Toxicology - Write a 1-2 page evaluation of the product. Include discussion of how it might ... animals, reptiles, insects, abrasions, puncture wounds, cuts, needle sticks ...

Write a 1-2 page evaluation of the product. Include discussion of how it might ... animals, reptiles, insects, abrasions, puncture wounds, cuts, needle sticks ...

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Toxicity and Human Health PowerPoint PPT Presentation

Toxicity and Human Health - Distribution of toxicants in the body Lymphatic system Lymph capillaries, nodes, tonsils, spleen, thymus, ... Heavy metals, like Pb Storage in liver.

Distribution of toxicants in the body Lymphatic system Lymph capillaries, nodes, tonsils, spleen, thymus, ... Heavy metals, like Pb Storage in liver.

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Chrysanthemum parthenium (L.) Berhn (feverfew) ???, ??? PowerPoint PPT Presentation

Chrysanthemum parthenium (L.) Berhn (feverfew) ???, ??? - Chrysanthemum parthenium (L.) Berhn (feverfew) , Aristolochia fangchi ( ) as anti-inflammatory, contains aristolochic acid (AA ...

Chrysanthemum parthenium (L.) Berhn (feverfew) , Aristolochia fangchi ( ) as anti-inflammatory, contains aristolochic acid (AA ...

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Drug Interactions Part 2 (Pharmacokinetic Interactions) PowerPoint PPT Presentation

Drug Interactions Part 2 (Pharmacokinetic Interactions) - Pharmacokinetic drug interactions are dealt in this presentation.

Pharmacokinetic drug interactions are dealt in this presentation.

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DRUG DISPOSITION PowerPoint PPT Presentation

DRUG DISPOSITION - 4. Describe how drugs are removed from the body. ... definition of prodrug an inactive form of a drug that is converted to active form in the body. ...

4. Describe how drugs are removed from the body. ... definition of prodrug an inactive form of a drug that is converted to active form in the body. ...

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ENDOSULFAN - ... available on the production levels since its ban in the United states after 1982. ... effects on human life is essential to impose a ban on the chemical. ...

... available on the production levels since its ban in the United states after 1982. ... effects on human life is essential to impose a ban on the chemical. ...

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Contaminant Fate and Transport Processes PowerPoint PPT Presentation

Contaminant Fate and Transport Processes - CIVE 7332 Lecture 4b Fate and Transport Advection and Dispersion Covered in Days 1, 2 Sorption and Retardation Chemical/Abiotic processes Volatilization ...

CIVE 7332 Lecture 4b Fate and Transport Advection and Dispersion Covered in Days 1, 2 Sorption and Retardation Chemical/Abiotic processes Volatilization ...

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Chapter%202.%20Metabolism%20and%20Elimination PowerPoint PPT Presentation

Chapter%202.%20Metabolism%20and%20Elimination - ... metabolism of a drug or other xenobiotic during the absorption process. Typically in the liver or gastrointestinal tract after oral administration. ...

... metabolism of a drug or other xenobiotic during the absorption process. Typically in the liver or gastrointestinal tract after oral administration. ...

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Toxicity and Human Health - Toxicity and Human Health Inneke Hantoro Toxicity Toxicity is the potential of a chemical to induce an adverse effect in a living organism e.g., man.

Toxicity and Human Health Inneke Hantoro Toxicity Toxicity is the potential of a chemical to induce an adverse effect in a living organism e.g., man.

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Toxicology - Acute response: rash, watering eyes, cough from brief exposure to ammonia ... Many chemicals are either soluble in water or in oil (fat, lipid) ...

Acute response: rash, watering eyes, cough from brief exposure to ammonia ... Many chemicals are either soluble in water or in oil (fat, lipid) ...

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Drug elimination 2: Liver PowerPoint PPT Presentation

Drug elimination 2: Liver - (e.g. heparan sulfate, chondroitin sulfate), sulfated ... FAD. FMN. Heme (Fe) NADPH H NADP 2H 2 e- 2 e- 2 e- O2. R-H. O2- R-OH. Cytochrome P450 ...

(e.g. heparan sulfate, chondroitin sulfate), sulfated ... FAD. FMN. Heme (Fe) NADPH H NADP 2H 2 e- 2 e- 2 e- O2. R-H. O2- R-OH. Cytochrome P450 ...

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Gastroretentive Dosage Forms PowerPoint PPT Presentation

Gastroretentive Dosage Forms - Title: A novel mechanism for oral controlled release of drugs by continuous degradation of a phospholipid prodrug along the intestine: In-vivo and in-vitro evaluation ...

Title: A novel mechanism for oral controlled release of drugs by continuous degradation of a phospholipid prodrug along the intestine: In-vivo and in-vitro evaluation ...

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Management%20of%20Acetaminophen%20Toxicity PowerPoint PPT Presentation

Management%20of%20Acetaminophen%20Toxicity - Peak concentration usually occurs between 60 and 120 minutes ... subsequent APAP levels of interest only ... with her and in fact the product is 'Tylenol ER' ...

Peak concentration usually occurs between 60 and 120 minutes ... subsequent APAP levels of interest only ... with her and in fact the product is 'Tylenol ER' ...

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Biodegradation Processes for Chlorinated Solvents Cive 7332 Lect 6 PowerPoint PPT Presentation

Biodegradation Processes for Chlorinated Solvents Cive 7332 Lect 6 - Title: Definition of Natural Attenuation Author... Last modified by: Hanadi Rifai Created Date: 4/12/1999 10:50:22 AM Document presentation format

Title: Definition of Natural Attenuation Author... Last modified by: Hanadi Rifai Created Date: 4/12/1999 10:50:22 AM Document presentation format

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Pharmacology Part 2 for Medical Students and Nurse PowerPoint PPT Presentation

Pharmacology Part 2 for Medical Students and Nurse - (PRICE LOWERED) Seriously the Easiest Way to Learn Pharmacology

(PRICE LOWERED) Seriously the Easiest Way to Learn Pharmacology

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Le mtabolisme des xnobiotiques chez les ruminants PowerPoint PPT Presentation

Le mtabolisme des xnobiotiques chez les ruminants - Flore microbienne tr s importante au niveau du rumen. ... R le d toxifiant de la population microbienne. paroi k ratinis e: limite l'absorption les mycotoxines dans le sang. ...

Flore microbienne tr s importante au niveau du rumen. ... R le d toxifiant de la population microbienne. paroi k ratinis e: limite l'absorption les mycotoxines dans le sang. ...

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Sulfation Biotransformation PowerPoint PPT Presentations