Title: Summary of Existing Problems in CART Therapy - PowerPoint PPT Presentation

Description: To be sure, the CD19-CART cell therapy technology should be individualized, but in addition to the CAR T design itself that will affect the treatment effect, the timing of application, the patient's basic condition, the dose of infusion, etc., will have a significant impact on the clinical effect. Different car gene vectors affect CART cell function, and currently used vectors are gamma retroviruses, lentiviruses, and car t plasmid. Even if the CAR structure is the same, the CART cells cultured by different research centers will be very different. In the composition of the new generation of CAR, a co-stimulation region was added, and in particular, the addition of CD28 or CD137 in the costimulatory region resulted in the proliferation of cells in vivo and the anti-tumor activity was significantly enhanced. – PowerPoint PPT presentation