Title: The Complete Guide to CAR-T Therapy - PowerPoint PPT Presentation

Description: The chimeric antigen receptor (CAR), a major component of CAR-T, confers T-cell independent ability to recognize tumor antigens in an HLA-dependent manner, allowing CAR-engineered T cells to recognize broader targets compared to native T cell surface receptors. The basic design of CAR includes a tumor-associated antigen (TAA) binding region (usually derived from scFV segments of the monoclonal antibody antigen-binding region), an extracellular hinge region, a transmembrane region and an intracellular signal Area. The choice of the target antigen is a key determinant of the specificity and availability of CAR and the safety of the genetically modified T cells themselves. – PowerPoint PPT presentation