Smallpox

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Smallpox

• Divya Raj

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(No Transcript)
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History

• 3,000 years ago- Africa, Asia, Europe
• New World- 1400s-1500s

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• Variola (major/ minor)
• Orthopoxvirus, Poxiviridae
• Brick
• Linear double-stranded DNA

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Smallpox Types

• Variola
• Vaccinia
• Cowpox
• Monkeypox

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Transmission

• Airborne
• Bodily Fluids
• Contagious

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Symptoms

• Fever
• Malaise
• Headache
• Fatigue
• Back Pain
• Vomiting, Diarrhea
• Rash- Spots, Blisters

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Vs. Chickenpox

• Severity- Superficial
• Location- Trunk
• Type- Stage of lesions
• Timing- Contagiousness

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4 Types

• Ordinary- 90, unvaccinated
• Modified- vaccinated
• Malignant- 5-10, children
• Hemorrhagic- 2, adults

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Prognosis

• 30 overall
• 50-75 ordinary- confluent
• 25-30 ordinary- semi-confluent
• 90- Flat
• 100- Hemorrhagic
• 1- Minor

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Complications

• Scars- 65-85
• Blindness- 2-5

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Treatment

• None
• Supportive
• Inoculation/ Variolation

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Vaccine

• Edward Jenner
• 1796
• Cowpox
• Side Effects

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Eradication

• 1979
• Atlanta, Koltsovo
• Destruction

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• Biological warfare
• Lack of vaccination

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References

• http//www.pbs.org/wgbh/rxforsurvival/series/video
  /index.html
• http//www.pbs.org/wgbh/rxforsurvival/series/disea
  ses/smallpox.html
• http//www.who.int/mediacentre/factsheets/smallpox
  /en/
• http//www.bt.cdc.gov/agent/smallpox/index.asp
• http//en.wikipedia.org/wiki/Smallpox
• http//www.nlm.nih.gov/exhibition/smallpox/sp_thre
  at.html
• http//www.mayoclinic.com/health/smallpox/DS00424/
  DSECTIONsymptoms
• http//www.eduplace.com/science/hmsc/6/a/cricket/c
  ktcontent_6a22.shtml