Chapter 10: Non-narcotic Anti-Inflammatory Analgesics

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Chapter 10 Non-narcoticAnti-Inflammatory
Analgesics

• Presented by
• Katie and Steffani

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NSAID

• Nonsteroidal anti-inflammatory drug
• It is a peripherally acting, anti-inflammatory
  analgesics.

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Various Actions of Asprin

• Anti-inflammatory
• Antipyretic
• Analgesic
• Anticoagulant

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Therapeutic Uses and Clinical Problems

• Reducing Fever
• Reducing Pain
• Reducing inflammation
• Reducing Clotting
• Anticoagulation action might prevent problems if
  a person needs to clot and they are chemically
  restricted by the aspirin.

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COX Inhibitor

• A chemical which inhibits the enzyme
  cyclooxygenase which converts a precursor
  substance to prostaglandins that cause
  inflammation.

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ONE TWO

• COX 1 functions primarily to mediate the
  production of prostaglandins that protect and
  regulate all functions in the GI tract and
  regulated blood platelets to initiate clotting.
• COX 2 produce prostaglandins that mediate pain
  and inflammation.

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Good ? and Bad ? of the Anticoagulant Action of
Aspirin

• Good ?- reduces hemostasis so is indicated in the
  treatment of Coronary Artery Disease (CAD) and is
  used to reduce risk of Cerebral Vascular Accident
  (CVA Stroke).
• Bad ?- causes symptoms ranging from dyspepsia to
  GI bleeds

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• Theoretical advantages of COX-2 inhibitors over
  NSAIDs (non-selective COX-inhibitors) are
  decreased GI toxicity and platelet blockage.

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• Correlation between COX enzyme and tumorigenesis
  COX enzyme has a role in exciting tumor cell
  growth because it is over expressed in malignant
  adenomatous polyps and colon cancer.
• Benefits of COX inhibitors have preliminarily
  shown efficacy in treating skin and colon cancer.