A Computer Aid for Radiologists: Improved Detection of Small Volume Lung Cancer on CR and DR Chest R

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A Computer Aid for RadiologistsImproved
Detection of Small Volume Lung Cancer on CR and
DR Chest Radiographs

• M.T. Freedman, S-C. B. Lo, F. Lure, X-W. Xu, J.
  Lin,
• T. Osicka, H. Zhao, R. Zhang
• Imaging Science and Information Systems Center
  and Oncology Georgetown University Medical
  Center, Washington DC
• Deus Technologies, LLC, Rockville MD

MT Freedman and SCB Lo are consultants to and
stockholders in Deus Technologies F Lure, XW Xiu,
J Lin, H Zhao, R Zhang are employees of Deus
Technologies
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A Computer Aid for Radiologists Improved
Detection of Small Volume Lung Cancer on CR and
DR Chest Radiographs

• Purpose
• To measure the lung cancer detection sensitivity
  on CR DR chest radiographs using a new
  commercially available CAD system
• RapidScreen RS-2000D. Deus Technologies, LLC
• To show that the detection rate of neoplastic
  nodules is equivalent in men and women
• To confirm the sensitivity of the CAD system on
  an independent set of cases

Georgetown University Medical Center, Washington
DC Deus Technologies, LLC, Rockville MD
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A Computer Aid for Radiologists Improved
Detection of Small Volume Lung Cancer on CR and
DR Chest Radiographs

• Methods Materials
• DR and CR 79 cases with solitary neoplastic lung
  nodules
• Diameters 9-30mm
• 13 cases with solitary metastases
• 66 cases with primary non small cell lung cancer
  (NSCLC)
• Comparison between the performance on
• Digitized film images
• DR and CR images

Georgetown University Medical Center, Washington
DC Deus Technologies, LLC, Rockville MD
4
A Computer Aid for Radiologists Improved
Detection of Small Volume Lung Cancer on CR and
DR Chest Radiographs

• The number of cancer cases included in the study
  by size
• RS-2000 (yellow) RS-2000D (red)

Georgetown University Medical Center, Washington
DC Deus Technologies, LLC, Rockville MD
5
A Computer Aid for Radiologists Improved
Detection of Small Volume Lung Cancer on CR and
DR Chest Radiographs

• The RapidScreen RS-2000D RS-2000 performance

System RS-2000 detected 53 of the total 80 cases
(66)
System RS-2000D detected 50 of the total 79 cases
(63)
CR and DR cases
Digitized films
Detection rates equivalent (66 vs 63) Cancers on
CR and DR are larger Study of digitized films
included cases that were 1 year prior to
clinical detection
Georgetown University Medical Center, Washington
DC Deus Technologies, LLC, Rockville MD
6
Male Female Distribution
A Computer Aid for Radiologists Improved
Detection of Small Volume Lung Cancer on CR and
DR Chest Radiographs

• Digitized film
• Male 80
• Female 0

• DR and CR
• Male 43
• Female 36

Georgetown University Medical Center, Washington
DC Deus Technologies, LLC, Rockville MD
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Primary lung cancer vs Metastases
A Computer Aid for Radiologists Improved
Detection of Small Volume Lung Cancer on CR and
DR Chest Radiographs

• Digitized film
• Primary NSCLC
• 80 cases -100

• DR and CR
• Primary NSCLC
• 66 cases 84
• Solitary Metastasis
• 13 cases 16

Georgetown University Medical Center, Washington
DC Deus Technologies, LLC, Rockville MD
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Sensitivity False Positives per ImageAll
cases Primary and Metastases
A Computer Aid for Radiologists Improved
Detection of Small Volume Lung Cancer on CR and
DR Chest Radiographs
False Positives per Image
Sensitivity

• Digitized film
• Male 66.3
• DR and CR
• Male 65.1
• Female 61.1
• All cases 63.3

• Digitized film
• Male 5.0
• DR and CR
• Male 5.4
• Female 4.5
• All cases 5.0

Georgetown University Medical Center, Washington
DC Deus Technologies, LLC, Rockville MD
9
Sensitivity False Positives per ImagePrimary
Non Small Cell Lung Cancer
A Computer Aid for Radiologists Improved
Detection of Small Volume Lung Cancer on CR and
DR Chest Radiographs
False Positives per Image
Sensitivity

• Digitized film NSCLC
• Male 66
• DR-CR NSCLC
• Male 67
• Female 67

• Digitized film NSCLC
• Male 5.0
• DR-CR NSCLC
• Male 5.3
• Female 4.5
• Together 5.0

Georgetown University Medical Center, Washington
DC Deus Technologies, LLC, Rockville MD
10
Conclusions
A Computer Aid for Radiologists Improved
Detection of Small Volume Lung Cancer on CR and
DR Chest Radiographs

• Sensitivity
• Near equivalent on digitized films and DR-CR in
  males
• 66.3 vs 65.1. 66 vs 67 for NSCLC
• Higher in males than females (not statistically
  significant)
• 65.1 vs 61.1. Average 63.3
• Number of false positives per image
• Equivalent on digitized films and DR-CR
• 5.0 vs 5.0
• Higher in males than females (not statistically
  significant)
• 5.4 vs 4.5

Georgetown University Medical Center, Washington
DC Deus Technologies, LLC, Rockville MD