A traditional Chinese medicine used in modern science

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Flavonoids

• A traditional Chinese medicine used in modern
  science

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Introduction

• Flavonoids are nearly ubiquitous in plants and
  are
• consumed regularly with the human diet
• Certain plants and spices containing flavonoids
  have been
• used for thousands of years in traditional
  Eastern medicine
• They are usually subdivided into
• flavanols
• anthocyanidins
• flavones
• flavanones
• chalcones

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The flavonoids displaya remarkable array of
biochemical and pharmacologicalactions
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Direct effect on mitochondrial calcium
uniporter
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effects of several of the most
naturallyabundant flavonoids on mitochondrial
Ca2 uptake in permeabilizedHeLa cells
6
Concentration dependence of the activation of
mitochondrial Ca2uptake by several natural
flavonoids
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Reversible activation of mitochondrial Ca2
uptake by kaempferolin permeabilized cells
8
Inhibition by Ru360 of the mitochondrial Ca2
uptake induced by kaempferol and SB202190
9
Effect of the absence of ATP in the activation
of mitochondrial Ca2 uptake by genistein or
SB202190
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attenuate apoptosis andprotein oxidation
in neuronal cell lines
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Scavenging effects of flavones on reactive
oxygen species generatedby GO
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Effect of flavone pretreatment on apoptosis in
neuronal cells exposed to oxidative stress
13
Effect of flavone pretreatment on the Bcl-2-
and Bax-protein levels
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Effect of flavone pretreatment on the
phosphorylation of Bcl-2 andBax proteins
15
Effect of flavone pretreatment on protein
carbonyl formation
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Antioxidant Activity

• flavonoids,as a dietary antioxidants,
  possess the potential to scavenge and quench
  various radicals and ROS

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As a antioxidant,flavonoids can function as
below

• Metal chelator
• scavengers of ROS
• chain-breaking antioxidants
• quenchers of the formation of singlet
• oxygen

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Effect of flavonoids on lipid peroxidation

• suppress lipid peroxidation

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• The illustrations above are only parts of
  the functions of flavonoids,which I think will be
  connective to my research on brain ischemia and
  reperfusion.
• In addition,the flavonoids also possess
  anti-inflammatory,antiallergic,hepatoprotective,
• antithrombotic, antiviral, and
  anticarcinogenic activities

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• Thank you !
• Lin Lin
• 
  2005.6.10.