Leeland H. Hartwell Ph.D

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2001???????

• Leeland H. Hartwell Ph.D
• ???-??????????

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????Saccharomyces cerevisiae
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Fig.3 ??cdc?????????(permissive
temperature,A),?????????(restrictive
temperature)????(B)???????????(Time-lapse
photomicroscopy).
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A ???
Fig.5 ????????????????cdc?????
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B cdc8
Fig.5 ????????????????cdc?????
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C cdc24
Fig.5 ????????????????cdc?????
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D cdc10
Fig.5 ????????????????cdc?????
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Fig.6 S. cerevisiae?????????????,????cdc?????.
??iDS,DNA???? initiation of DNA DS,DNA?? DNA
synthesis mND,????? medial nuclear division
lND,????? late nuclear division BE,??? bud
emergence NM, ??? nuclear migration CK,????
cytokinesis CS,???? cell separation MF,????
mating factor
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Fig.7 ????????,??????????????????,????????.
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Fig.8 ??????????,??????????????,???????(A)????(B).
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Fig.10 ????(A)????(B)???????.?????????????????????
??,????????????,????????????????,????G1?.
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??cdc28
PD
Fig.11 ?????????????
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Paul Nurse
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Fig.11 ???????????cdc?????????????
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Fig.15 ???x????????.????(A)?????(B)??????.????A??
???????G1????B???????????????,??????G2???????????.
G1????????????????????,??????????????????????.????
(C)?????(D)?rad9?????.??????G1???????(C)???????,??
?????????????(D)
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Fig.16 ????????????????????. cdc13
RAD9????????????????????,??????(A)?cdc13 rad9
??????????,????(B).
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1.?????????????????
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• 2.????????????????????,????

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