Prsentation PowerPoint

1
CHARACTERIZATION OF SOLID LIPID NANOPARTICLES
Cécile Allais, F. Artzner, T. Narayanan, T.
Gulik-Krzywicki, G. Keller and M.
Ollivon Equipe de Physico-Chimie des
Systèmes Polyphasés, UMR CNRS 8612, Faculté de
Pharmacie, 5 Rue Jean-Baptiste Clément 92296
Chatenay-Malabry Cedex, France E.S.R.F.,
Grenoble, France Centre de Génétique
Moléculaire, CNRS, Gif-sur-Yvette,
France cecile.allais_at_cep.u-psud.fr
2
(No Transcript)
3
(No Transcript)
4
Cocoa Butter/Cholesterol Nanoparticles
5
OPTIC MICROSCOPY IN DARK FIELD
Nanoparticles just After Preparation at Room
Temperature
Nanoparticles Stocked 1 Month at 4C
Spherical Particle
Non Spherical Particle
6
ELECTRONIC MICROSCOPY
(T. Gulik-Krzywicki)
Presence of Flat and Hemispherical Sides
7
COCOA BUTTER POLYMORPHISM IN NANOPARTICLES
(SAXS on ID2 Beamline, E.S.R.F., T. Narayanan)
Cocoa Butter Nanoparticles
X-ray patterns at10C Lipidseault1 (w/w)
8
POLYMORPHISM CONTROL ?
(SAXS on ID2 Beamline, E.R.S.F., T. Narayanan)
CB/Cholesterol 50/50 (w/w) Nanoparticles
X-ray patterns at10C Lipidseault1 (w/w)
9
POLYMORPHISM CONTROL ?
(SAXS on ID2 Beamline, E.S.R.F., T. Narayanan)
CB/Cholesterol 50/50 (w/w) Nanoparticles
10
CONCLUSION
? MultiTechniques Approach -size -shape
? Non Homogeneous Particles microsegregation
? Polymorphism Study low concentration 1 (w/w)
2L
11
X-RAY DIFFRACTION
(T. Narayanan, E.S.R.F., Grenoble)
ID 2 Beamline