animal feed supplements, veterinary product producers, natural veterinary products

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AROSOL CHEMICALS PRIVATE LIMITED Manufacturer and
Exporter of Natural remedies Animal health
Medicines
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METHIONINE

• A Natural-Herbal methionine

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Methionine (abbreviated as Met or M) is an
a-aminoacid with the chemical formula
HO2CCH(NH2)CH2CH2SCH3. This essential amino acid
is classified as nonpolar. Together with cystein,
methionine is one of two sulfur-containing
proteinogenic amino acids. Its derivative
S-adenosyl methionine (SAM) serves as a methyl
donor. Methionine is an intermediate in the
biosynthesis of cysteine, carnitine, taurine,
lecithine, and other phospholipids. Improper
conversion of methionine can lead to
atherosclerosis.
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Methionine is required for It assists in the
breakdown of fats and thereby prevents the
build-up of fat in the arteries, as well as
assisting with the digestive system and removing
heavy metals from the body since it can be
converted to cysteine, which is a precursor to
glutathione, which is of prime importance in
detoxifying the liver. The amino acid methionine
is also a great antioxidant as the sulfur it
supplies inactivates free radicals. It is also
one of the three amino acids needed by the body
to manufacture creatine monohydrate, a compound
essential for energy production and muscle
building.
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Deficiency of methionine Severe deficiency may
manifest in dementia, while lesser deficiencies
may be known by symptoms like fatty liver, slow
growth, weakness, edema and skin lesions.
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Methionine is required in the diet and thus is
considered an essential amino acid. Methionine
helps in the biochemical breakdown of fats in the
body this action prevents the accumulation of
fat in the liver. The availability of methionine
in the body may affect the biochemical synthesis
of the amino acids cystein and taurine. Methionine
also aids in the rapid detoxification of harmful
compounds such as lead and any other heavy metals
which may cause toxic side effects due to their
presence in the body. Methionine also actively
reduces the onset of muscular weakness. Methionine
is also believed to be beneficial for proper
bone formation.
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Methionine has a powerful antioxidant action
against free radicals produced in the natural
metabolic processes of the body. The amino acid
methionine is also an excellent source for the
essential mineral sulfure, which quickly
inactivates free radicals produced in the body.
The amino acid is also required during the
synthesis of nucleic acids, collagen and
different proteins found in almost every cell- it
is a constituent of many enzymes and proteins
found in different parts of the body.
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Methionine is not synthesized in the body and is
considered to be an essential amino acid. It
needs to be obtained in the diet from methionine
rich food sources or via dietary supplements of
methionine or protein rich complexes in easily
available form.
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Methionine is a lipotropic, or a chemical
substance that helps the liver process fats
(lipids). Other lipotropics include choline,
inositol, and betaine (trimethylglycine), all of
which help prevent the accumulation of fat in the
liver and thus ensure normal liver function,
which is essential for the elimination of toxins
from the body. Methionine also supports liver
function by regulating glutathione supplies..
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Methionine is essential for the formation of
healthy collagen used to form skin, feathers, and
connective tissue, and helps reduce the level of
inflammatory histamines in the body. Methionine
is an essential vitamin, which means it must be
obtained through dietary sources..
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A FATTY LIVER (POULTRY)
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Higher level of methionine is required to meet
with the increased tissue demands for fast growth
and high production. It helps optimize protein
synthesis and improves the tone and pliability of
the skin and strengthens feathers. Methionine is
essential for the absorption and transportation
and bioavailability of some essential minerals in
the body. It also acts as a methyl donor and
prevent excess fat buildup in the liver.
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Methionine deficiency causes

• Slow growth in broilers, layer chicks and
  growers.
• Poor feed conversion ratio, lowered egg
  production.
• Liver damage.
• Loss of muscle tone and fat.
• Skin tone and feather loosening.
• Immune depression.

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Natural Methionine
Nature has provided methionine to plants as
dipeptides and oligopeptides along with its
precursors and intermediates to facilitate
optimum biosynthesis of methionine, as per birds
needs. Herbs also have enzymes required for
conversion of methionine into S-Adenosyl
Methionine (SAM) which is Active Methionine.
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• Herbal Methionine as researched based formulation
  contains bioactive natural methionine in free as
  well as conjugated dipeptide and oligopeptide
  forms.
• Herbal Methionine contains the precursors and
  intermediates of methionine, folic acid.

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• Serine - Serine is an efficient contributor to
  methionine formation. Natural serine present in
  Herbal Methionine provides significant
  contribution to methionine production. Herbal
  Methionine contains all of these pre-requisites
  for methionine formation from serine.
• Aspartic Acid Like serine, natural aspartic
  acid present in Herbal Methionine is converted
  through homoserine into homocysteine and then
  methionine, thereby providing an useful source of
  methionine bio-synthesis.

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• Folic Acid - Folic acid present in Herbal
  Methionine helps in one carbon transfer reactions
  and thus spares methionine for protein synthesis
  and methylation functions.
• Recycler of Methionine S-Adenosyl Methionine
  (SAM) obtained from methionine is used in the
  synthesis of creatine. The homocystine further
  gets reconverted into methionine with the help of
  phosphatidyl choline and folic acid present in
  Herbal Methionine, for sustained bioavailability
  and activity of methionine.

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HERBAL COMPOSITION

• Andrographis paniculata 350 gms.
• Zea mays 250 gms.
• Ocimum sanctum 300 gms.
• Asparagus racemosus 100 gms.

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Causes of Poor Feathering The absence of feathers
on birds can result from any of several causes
and can be separated into two groups 1) those
birds that cannot grow feathers and 2) those
birds that pull or break them off. Either
situation can be reversed by correcting the
problem's cause. The most common reason that
feathers do not develop is a deficiency of a
critical protein constituent (amino acid) from
the diet of the birds. The feathers of birds
contain high levels of a subunit of proteins
called "methionine." Methionine is one of only a
few amino acids that contain sulfur, and sulfur
is a major constituent of feathers. If bird diets
are deficient in any single amino acid, it will
most likely be methionine. An adequate level of
methionine is required in the diet and a
deficiency results in reduced growth and feather
development. A methionine deficient bird will
tend to eat feathers in an attempt to satisfy a
craving for this amino acid. A bird may even pull
them from its own body.
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Few ingredients used in making poultry diets
contain adequate amounts of methionine, so
manufactured methionine must be added to the
dietary mixture to ensure that the birds receive
an adequate amount. All quality poultry feeds are
designed to contain adequate methionine and
prevent reduced body growth and feather
development. However, if additional grains (such
as corn) are fed with the complete feed, then the
amount of methionine consumed by the bird can be
inadequate for providing growth and feather
development. Feeding of additional grains with
complete poultry feeds is not recommended.
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CH3
CH3
CH3
CH3
Methionine-S-CH3
CH3
Figure 4. Metabolism of methionine and cysteine.
THF is tetrahydrofolate.
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• In a study published in British Journal of
  Nutrition (1985), Linda Saunderson reported that
  l-methionine incorporates better into different
  tissues like breast, leg, skin and brain of
  broiler chicks as compared to dl-methionine.
• Linda Saunderson also reported that l-methionine
  excretes significantly lesser (less than 5 times)
  as compared to dl-methionine, providing sustained
  bio-actibity

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14C incorporation (per min per gm tissue) 14C incorporation (per min per gm tissue) 14C incorporation (per min per gm tissue)
dl-methionine l-methionine
Breast 2851 4249
Leg 2821 4169
Skin 2431 4540
Brain 1797 3468
14C in excreta extract 14C in excreta extract 14C in excreta extract
Excreta 9.59 1.88
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• ADVANTAGES
• Provides 100 Methionine to the animal/bird for
  optimum growth.
• Controls fat metabolism hence prevents fatty
  liver syndrome
• Provides energy so that the animal/bird remain
  in healthy lively state
• Keep the Liver in its vibrant state of
  performance hence there is production of optimum
  bile secretion and prevention from aflatoxicosis
• Methonine is helpful in optimum cell synthesis
  hence it provides basic building blocks for newer
  cells.
• Optimizes hatchability

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• INDICATIONS
• Improves skeletal muscular growth
• Improves FCR Anabolic effect
• Optimum production
• Enhanced Convalescence
• Healthy Digestion
• Early recovery from skin diseases and
  feather loss
• Recovers Leg Weakness
• DOSAGE FORM Powder Oral
• PRESENTATION -
• 1 Kg Pack 20 Kg Pack

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Effect of supplementing Herbal Methionine on
performance and immune response of broilers
Abstract A study was conducted with broilers to
find out the effect of addition of herbal
methionine (1 g/kg) to a basal diet containing
crude protein, 223 g/kg, ME, 1225 MJ/kg,
Supplemental levels of methionine was found to be
highly effective in improving the growth, food
consumption, food conversion ratio and immunity
of broilers. A higher value for leucocyte
migration inhibition was observed in chicks fed
on the diet containing 1.5 g/kg methionine which
indicated a significant improvement in cellular
immune response. Hamagutination test and ELISA
indicated enhanced antibody titres in chicks
receiving 2.5 g/kg of herbal methionine, showing
a significantly better humoral immune response.
Hence it is advocated to supplement Herbal
Methionine for efficient FCR, growth and enhanced
immunity of boilers.
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Growth and Carcass Quality of Slow Growing Chicks
on diets containing Different Levels of Herbal
Methionine The responses of slow growing chicks
to different dietary levels of herbal methionine
and its interaction were investigated during the
starter-grower period from 1 to 56 d of age.
Therefore, a basal marginally herbal methionine
deficient all-mash corn-soybean meal diet was
formulated to contain 0.32 herbal methionine,
0.65 total sulphur amino acid (TSAA) and
adequate level of choline (NRC, 1994). This diet
was supplemented with 0, 0.05 and 0.10 of herbal
methionine. Thus, there were nine experimental
diets each diet was fed to 40 chicks divided
equally among 5 replicates of eight chicks each.
Herbal Methionine level at 0.37 and 0.42
significantly improved BWG by 2.1 and 8.1 and
FCR by 4.5 and 8.6 compared to the basal diet,
respectively. Moreover, herbal methionine at 0.37
and 0.42 significantly decreased serum AST and
ALT, and abdominal fat compared to the basal
diet. There were significant interaction between
methionine level. In conclusion, slow growing
chicks (14.6 g/d) during 1-56 d of age could be
fed diet containing 0.42 methionine.
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