The Preventive Role of Nutrition for BRCA1/2 Mutation Carriers Sharon Bar-Gil, Ph.D., RH (AHG)

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The Preventive Role of Nutrition for BRCA1/2
Mutation CarriersSharon Bar-Gil, Ph.D., RH
(AHG)

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Functional Medicine

• Goal optimal function
• Integrative
• Science based
• For prevention and treatment
• Patient centered - focusing on the individual
  and tailoring a unique plan to restore balance
• Tools nutrition, herbs, supplements and life
  style modifications

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Objective

• Understand the Role of Nutrition in Cancer
  Prevention.

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Youre not ill yet, Mrs. Smith, but youve got
potential.
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• Nutrition is an Essential Tool in Your
• Cancer Prevention Tool Kit.
• Nutritional interventions can
• Reduce prevent further mutations
• Support proper cell growth and death

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Agenda

• Nutrigenomics nutrition can change gene
  expression
• Natural agents that can help regulate BRCA1/2
  genes
• Fatty acids
• Green tea
• Turmeric

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What is Food?
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Nutrigenomics You can turn genes On or
Off

• Nutrigenomics is the study of how foods interact
  with your genes and alter their expression.
• Genes do not function in isolation.
• They interact with each other as well as with
  their environment.
• Nutrigenomics provides the ambitious goal of
  optimizing an individuals health via nutritional
  interventions. FASEB Mutch et al. 19 (12) 1602.
  (2005)

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Nutrition Can Change Gene Expression

• Animals fed healthy or nutrients deficient diet.
• Those on deficient diet developed colon cancer
  within 1 year.
• 2,000 genes altered their expression toward a
  cancer profile
• Pattern of gene expression reverted toward a
  healthy profile when nutrients added back to
  diet.
• Augenlicht LH Nutritional genomics and
• proteomics in cancer prevention conference.
• J. Nutr. 133 2410S2416S, 2003

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Agenda

• Nutrigenomics How Nutrition can change gene
  expression
• Natural agents that can help regulate BRCA1/2
  genes
• Fatty acids
• Green tea
• Turmeric

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Fatty Acids Regulate BRCA1/2

• Fatty acids (such as fish oils) can regulate
  BRCA1/2 expression
• Omega 3 (EPA DHA) fatty acids have been shown
  to reduce pathological cell growth.
• Omega 6 fatty acids have been found to induce
  tumor proliferation.
• DHA supplementation significantly reduced the
  incidence of tumors (30) and led to a 60
  increase BRCA1 protein level.
• Bernard-Gallon et-al, British Journal of
  Nutrition (2002), 87, 281289
• MARIE-LISE JOURDAN, ET-AL ,ONCOLOGY REPORTS 17
  713-719, 2007

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Where Are They Found?

• Omega 3 cold water fish, flax seed, dark leafy
  greens, nuts and seeds, olive oil, grass fed beef
• Omega 6 - Safflower oil, Sunflower oil, Corn oil
  Sesame oil, Soybean oil, Walnut oil, commercially
  raised beef

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Green Tea Gene Expression

• Helps DNA repair
• Inhibits promoting genes (MMP-2, MMP-9)
• Increases inhibitory genes
• Induces apoptosis
• Prevention dosage
• 300-600 mg (gt50 EGCG)
• 2-4 caps. daily
• Katiyar, S.K., et al, 1992. Green Tea in
  Chemoprevention of Cancer.
• Adhami, et al, J. Nutr, 2003
• Tang et al. Int J Cancer, 2007
• Lozano, et al, Febs J, 2006
• Susan McCarthy, et-al, molecular Oncology, Volume
  1, Issue 2, Pages 196-204 (September 2007)

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Green Tea Extract Inhibits PC inHuman Clinical
Trial

• 60 volunteers with PC.
• Consumed 200 mg 3 per day or placebo for 1
  year
• At 1 year 1 tumor was diagnosed in the green tea
  group (3), while 9 cancers were found in the
  placebo (30)
• S. Bettuzzi, et-al, Cancer
• Research 66, 1234-1240,
• January 2006

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Turmeric Synergy with Chemotherapy

• Turmeric has many mechanisms through which it
  prevents/destroys cancer cells
• Inhibit the proliferation of tumor cells
• Destroy mutated cancer cells
• M.D. Anderson Cancer Center (2008) Mice
  injected with aggressive breast cancer cells.
• Divided to 4 groups
• No treatment 95 metastasis
• Taxol only 75 metastasis
• Curcumin only 50 metastasis
• Curcumin Taxol 22 metastasis
• Research dosage 8 g daily
• journal Clinical Cancer Research, October 15th,
  2005
• M.D. Anderson Cancer Center, Sept. 2008

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Prevention The Concept of Total Load

• Most of us are exposed to constant low level of
  toxins.
• Such exposure is not well studied
• Difficult to measure
• Biochemical individuality different risks
• Multiple sources of exposures have synergistic
  effects
• The ability to inhibit or repair mutations
  depends, to a great extent, on lifestyle choices
• The concept of total load
• Decrease exposure
• Increase protection

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Talk to Your Genes With Food

• Drink about 1 glass of red wine 3-5 days a week.
• Limit sugar intake
• Consume moderate amounts of fish, eggs, poultry
  and/or wild meats up.
• Limited consumption of red meat
• Eat organically grown or wild foods.
• Spice it Up Use herbs kitchen spices liberally

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Talk to Your Genes With Food

• Consume mostly food from plant sources, including
  fruits, vegetables, whole grains, beans, nuts,
  and seeds
• Aim for 2-3 fruits 5 vegetables daily
• Eat minimally processed and mostly seasonally
  fresh foods.
• Eat a Rainbow Choose deeply colored produce and
  eat full rainbow of colors daily.

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• You can be in control when it comes to actively
  maintaining your nutritional status.

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Thank You

• Sharon Bar-Gil
• Ph.D., R.H. (AHG)
• www.sharonbargil.com
• E-mail sharon_at_sharonbargil.com
• Tel [phone]