Helping to Cure Cancer

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Helping to Cure Cancer

• Computer Science and Biology

Sam Danziger Department of Biomedical
Engineering University of California, Irvine
Dr. Rainer Brachmann School of Medicine
Dr. Richard Lathrop School of Information and
Computer Science
Jue Zeng School of Medicine
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Cancer Who Gets It
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Bone Cancer What Did It Do?
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1 in 3 People Will Get Cancer
Cancer is an important problem
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What is Cancer?
www.rit.edu
Look Closely Youre Made up of Cells !
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One Cell Goes Bad
And Makes MANY Copies Of Itself
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How Your Body Protects Itselfp53!
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We Want To Understand p53
What We Know
But Theres So Many Ways It Can Break
Spiral Galaxy M101 http//hubblesite.org/
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Use Computers To Help
Computer Models
Biology
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How To Make a Computer Model of p53Modeling done
using Amber with zinc ion characteristics tuned
by Dr. Qiang Lu working in Dr. Ray Luis lab.
2. Substitute one or more amino acids to mutate
the protein.
1. Use a wild type crystal structure of the
protein in question.
4. Minimize the energy of the new mutant protein.
3. Apply simulated physical laws to determine an
energy function.
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How Does A Computer Look At A Model?
3D p53 Molecule
2D Surface Map
Features from a grid
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How Does Artificial Intelligence Work?
Training Set the parameters with n features.
Testing Use the parameters to predict unknown
classes
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The Computers and Biology Teach Each Other
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Ultimate Goal
Intermediate Goals
Research p53 Faster Than Biologists Could Do By
Themselves
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Some People Whove Helped
Rainer
Sam
Rick
Jue
Larry
Hiroto
Jonathan
Josh
Jianlin
Pierre
Qiang
Ray
Vinh
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People Who May Soon Help
YOU!