Aterogeneza: znacaj lipidskih poremecaja i oksidativnog stresa' Novi faktori rizika za ishemijsku bo

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Aterogeneza znacaj lipidskih poremecaja i
oksidativnog stresa.Novi faktori rizika za
ishemijsku bolest srca
Bioloki mehanizmi regulacija - Fiziologija
kardiovaskularnog sistema -

• Doc. Dr Zvezdana Kojic
• Decembar 2004.

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Atherosclerosisa multifactorial disease
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Arterial wallstructure and function
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Different stages of atherosclerotic
plaquedevelopment
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Vascular endothelium modificationin
atherosclerosis
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Plaque formation1 Fatty streak
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Plaque formation2 Fibrous cap
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Plaque formation3 Lipid core
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Lipid core constitutionActivated macrophages
accumulate lipids
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Lipid core constitutionLDL oxidation
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Parietal vascular inflammationThe activated
macrophage produces inflammatory cytokines
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From plaque to thrombosis, key event plaque
rupture
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Plaque vulnerabilityKey role of macrophages
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Vulnerable plaqueKey role of the macrophage in
vascular wall inflammation
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Fibrinogen is an independent risk factorfor
atherosclerosis
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Vulnerable plaqueKey role of the macrophage in
the degradation of the fibrous cap
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Tissue factor the initiator of coagulation and
thrombogenesis in vivo
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Tobacco and atherosclerosis
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Dyslipidemia and atherosclerosis
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Novi faktori rizika

• ADMA ?
• homocistein
• grelin, leptin
• mokracna kiselina
• Mg, Fe, Zn, Cu

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Literatura

• Li AS., Glass CK. PPAR and LXR-dependent pathways
  controlling lipid metabolism and development of
  atherosclerosis. J Lip Res., 2004, 45(12)
  2161-73.
• Francois M, Kojda G. Effect of hypercholesterolemi
  a and of oxidative stress on the nitric
  oxide-cGMP pathway. Neurochem Int. 2004
  Nov45(6)955-61.
• Bursill CA, Choudhury RP, Ali Z, Greaves DR,
  Channon KM. Broad-spectrum CC-chemokine blockade
  by gene transfer inhibits macrophage recruitment
  and atherosclerotic plaque formation in
  apolipoprotein E-knockout mice. Circulation,
  2004, 110(16) 2460-6.