Biosynthesis and catabolism of pyrimidine nucleotides.

1

• Biosynthesis and catabolism of pyrimidine
  nucleotides.

2
Nucleases (DNA-?se ? RNA-ase) decompose
nucleoproteins to oligonucletides
3
Phosphodiesterases decompose oligonucleotides to
mononucleotides
Nucleotides structure
4
Nucleoti-dases split off phosphoric acid with
the formation of nucleosides
5
Nucleosidases decompose nuclesides to nitrogenous
base and pentose
Nitrogenous bases
6
DECOMPOSITION OF MONONUCLEOTIDE
7
DECOMPOSITION OF NUCLEIC ACIDS IN
INTESTINE AND TISSUE
Nucleoproteins (nucleic acids proteins)
Pepsin, gastricsin, HCl
Nucleic acids
Histones, protamines

Nucleases (DNA-ases, RNA-ases)
Oligonucleotides
Phosphodiesterases
Mononucleotides
Phosphatases
Nuclesides
Phosphoric acid

Nucleosidases
Nitrogenous bases

Pentose
8
DESTINY OF NITROGENOUS BASES, PENTOSES AND
PHOSPHORIC ACIDS IN THE ORGANISM
Nitrogenous bases
oxidation to the end products
oxidation with energy formation synthesis of
nucleotided synthesis of hexoses
synthesis of coenzymes
Pentoses
phosphorilation ATP
synthesis synthesis of
phospholipids buffer systems
constituent of bones, cartilages
Phosphoric acid
9
Dis-integ-ration of pyri-midine nucle-otides
10
SYNTHESIS OF PYRIMIDINE NUCLEOTIDES
11
OROTACIDURIA
inherited disorder of pyrimidine synthesis caused
by a deficiency of the enzyme of
orotate-phosphoribosyltransferase and
decarboxylase. Symptoms excess of orotic acid
and its excretion with urine (1.0-1.5 g) -mental
and physical retardation -megaloblastic anemia
12
TREATMENT OF OROTACIDURIA
Taking of uridin during the whole life