???? Medical Protozoa

1
???? Medical Protozoa

• ????,????
• ?????,????
• ????,?,?,??,??
• ????,????40??

2
???????(basic structures)

• ???(nucleus)??(reprodution)???(?????)
• ???(cytoplasm)?/????,?????(ingestion)???(metaboli
  sm)
• ???(plasma membrane)??????????????????
• ?????????????

3
??????(mode of reprodution)

• ????(asexual)
• ???? ?????,?????
• ????????,????
• ????(sexual)
• ????,????

4
???????(life cycle patterns)

• ?????one-stage form
• two-stage form
• ?????mammals-mammals
• ?????mammals-insect vectors

5
???????(characteristics of protozoan infection)

• ?????????????(parasitemia)
• ???????
• ????opportunistic protozoa

6
??????(medically important species)

• ???(amebae)???????
• ???(flagellates)?????
• ???(sporozoites)???,???
• ???(ciliates)???????

7
??? Amoeba

• ??????
• ???Naegleria sp.
• Acanthamoeba sp.
• ??Entamoeba coli
• ??Entamoeba histolytica

8
???????

• Entamoeba histolytica

9
? ?

• ????,??5??
• ??????4-10??
• ??????1
• ????,??????
• ????

10
???? (Morphology)

• 1.???? (trophozoite)
• 20-40?m,????
• ?????,?????
• ????

11

• 2.???(cyst)
• ?????
• ????(12 nuclei),???????(chromatoid body)
• ????4 nuclei cyst

12
(No Transcript)
13
(No Transcript)
14
(No Transcript)
15
?????(Life cycle)

• Cyst?Trophozoite?Cyst
• ???4 nuclei cyst(?)
• ???trophozoite(?,??)
• ????cyst?trophozoite

16
(No Transcript)
17
?????

• liver(????)
• lungs(?????)
• brain(??????)

18
????(Pathogenesis)

• (?)????(pathogenicity)
• Virulencepathogenic species
• Bacterium????
• Host

19
(?)??????(virulence)

• ???????
• ??-??
• ?
• ??-??,???,??
• ?
• ??-???????NO???

20
(?)Pathology

• ??????surface histogenesis lesions
• ??????(??)flask-like ulcers
• ????(??????)?????(necrotic abscess)

21
(No Transcript)
22
(?)???? (clinical types)

• ?????(intestinal amoebiasis) ??(amoebic
  dysentery)
• ??(amoebic colitis)
• ??????(extraintestinal amoebiasis) amebic
  abscess
• ?????????????

23
????????????

• ?????????
• ??????IFN? ? M?
• ??????

24
????(Laboratory diagnosis)

• ?????(etiological examination)
• ????????????? ???????
• ???????????
• ?????
• ?????????? ????B?
• ?????(immunological diagnisis)

25
?????? E.dispar

• Morphology
• ?E.histolytica????
• Pathogenesis
• Non-pathogenic species

26
??????(E. coli)

• Trophozoite2050?m,???? ??????,??? ??????
• cyst1030?m ,??48?

27
????(Epidemiology)

• ??????,???
• ??? ????????
• ????3?
• ?????,??,????
• (???????)
• ???

28
??????

• ????????
• ??? ?????????
• ???????????????
• ??????? (??????)
• ????????

29
?????????

• ???????
• Naegleria fowleri
• ????????
• Acanthamoeba sp.

30
??Life cycle and morphology(1)

• ???? ????
• Trophozoite ????? ????
• ????
• Cyst ?? ???

31
Life cycle and morphology(2)

• ???? ?????
• Infection stage ??? ???
• Infection way ???? ????/?
• ????? ????/??
• Parasitic site ? ?/?/??

32
????( Pathogenesis )

• ???? ?????
• ?????? ???,???
• ???? ????
• ???,??? ???,??
• ???? ??

33
????( Diagnosis )

• ???????????
• ?????
• ?????
• (??????)

34
????(Prevention and treatment )

• ??????? ????
• ??????
• ??????????

35
???????

• Giardia lamblia

36
????(Morphology)

• 1.???(trophozoite)
• ????
• ?????????
• ???1?
• ????
• ??????

37
Another example of a Giardia lamblia troph.  The
two nuclei are easy to see in this image. 
38

• 2.??(cyst)
• ???
• ????
• 2-4??
• ????????

39
The nuclei and axostyles are clearly visible.
40
(No Transcript)
41
?????(life cycle)

• cyst-trophozoite-cyst
• Infection stage 4 nuclei cyst
• Parasitic siteduodenum
• Excrement stagecyst/
• trophozoite

42
??? ?(Pathogenesis)

• ?????????
• ????(clinical types)
• 1.???(carrier)???
• 2.?????,????
• ???????
• 3.????????

43
??? ?(Laboratory diagnosis)

• ???????trophozoite
• ???????cyst
• ???????trophozoite

44
??? ?(Epidemiology)

• ?????, ??gt??
• ?????????
• ??????,?????
• ???????????

45
??? ?(Control)

• ????????
• Treatment
• ???(metronidazole)

46

47
?????????

• ? ? ???? ? ?
• ????? ???????? ???
• ????? ????? ??????
• ????? ?? ?????
• ?? ?? ???/Chagas?

48
?????????

• ????? ?????????
• ????? ??
• ????? ????????
• ????? ????
• ?????? ???

49
Visceral leishmaniasis has a wide geographic
distribution.
50
???????

• Leishmania donovani

51
? ?(1)

• ????
• ??????,??????????
• ????????????????,?????

52
(No Transcript)
53
Leishmania amastigotes, bone marrow aspirate,
Giemsa stain
54
? ?(2)

• ????
• ????????
• ??????????
• ?????????

55
(No Transcript)
56
(No Transcript)
57
???

• ?????,?????
• ???????(????)
• ?????????????????????
• ???????

58
???

• ???? ????
• (????) (??????)

59
The infection is transmitted by various species
of Phlebotomus, the sand fly.
60
????

• M??????
• ????????????
• ???????

61
????

• ?????,?????
• ??????,??????
• ??????,?????
• ???????(????)

62
????

• ????????????????
• ????
• ??????,?????

63
????

• ????????????(?????)

64
?????

• lt???gt
• ???????80??
• ?????????
• lt???gt
• ?????

65
????

• ??????
• ????????
• ??????

66
????????

• ???(???) ??? ???? ??
• ???(???) lt10y?? ???? ??
• ????? lt2y?? ???? ??
• (???) ????

67
????

• ???????
• ????
• ???????
• ????

68
???????

• ???,????,???
• ?????,???,30m
• ??????
• ??????

69
????

• ????,??5??, ???? 97.4
• ??????
• ????
• ????

70
???????

• ????????
• ??????
• ??????,????? ??,???