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New Faculty Orientation

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Title: New Faculty Orientation


1
  • New Faculty Orientation

2
Office of Research Services (ORS)
3
Office of Research Services Research
Development Services
  • Helping you navigate your research portfolio

3
4
(No Transcript)
5
Total Dollars Awarded FY 2008- FY 2012
Millions
2010 includes ARRA awards
6
Office of Research Services (ORS)
  • Research Development
  • Proposal and award processing
  • Pre-award
  • Post award (non financial)
  • Budget review
  • Fit with scope
  • Statutory, fiscal compliance
  • All grant submissions
  • Sponsors Government, industry, foundations, etc.
  • Modes Grants.gov, Proposal Central, paper, etc.
  • All grant and contract approvals
  • All negotiations
  • Other agreements
  • Material transfer
  • Professional service agreements
  • Standard information
  • Sponsor policy updates
  • Procedural guidance

7
Research Development Tools, Resources,
and Processes
  • Searchable Databases
  • Limited Competitions
  • Internal Funding

8
Finding Funding
  • Resources to find grants matching your research
    interests
  • Examples
  • Pivot-COS
  • Grants.gov
  • Grants Resource Center (GRC)
  • IRIS
  • FedBizOpps

9
Pivot-COS
  • Pivot - Community of Science
  • All disciplines, all sponsor types, international
  • Save multiple, customized funding alerts
  • Track opportunities
  • Matching function
  • Find collaborators
  • http//pivot.cos.com/

10
GRC
  • Grants Resource Center
  • Maintains own database and publications that
    cover all relevant federal grants and many
    private grants
  • Maintains a library of funded proposals
  • Connect faculty members with program officers
  • www.aascu.org/grc
  • (login uic, pswd awards)

11
Limited Competitions
  • Sponsor makes university prescreen and select
    proposal
  • Peer reviewed typically evaluated for
  • Program Compliance
  • Scientific Merit
  • Management
  • Education/Training
  • MUST have prior authorization to submit

12
Limited Competition Process
  • Announcement
  • Letter of Intent
  • White Papers (if necessary)
  • Peer Review ( if necessary)
  • Authorization
  • Feedback (if warranted)
  • This process typically takes from 2 to 4 weeks

13
(No Transcript)
14
Campus Research Board Pilot Grants
  • Up to 20,000 over 1 year
  • Purpose
  • Foster pilot research
  • Nurture career trajectories of promising
    early-stage investigators
  • Leverage extramural funding
  • Eligibility
  • FT tenure or non-tenure track faculty
  • Within 8 years of terminal degree
  • Fall Deadline
  • LOI late summer, 2013
  • Application Autumn, 2013
  • http//tigger.uic.edu/depts/ovcr/research/funding/
    CRB.htmleligibility

15
Chancellors Discovery Fund for
Multidisciplinary Research
  • Up to 40,000 over 2 years
  • Purpose
  • Foster pilot research using the expertise of
    varied disciplines
  • Nurture career trajectories of promising
    early-stage investigators
  • Leverage extramural funding
  • Encourage new or support early stage
    collaborations
  • Eligibility
  • FT tenure or non-tenure track faculty
  • Minimum of two Principal Investigators
  • At least one PI must be within 8 years of their
    first faculty appointment
  • FY 13 Deadline
  • LOI Fall, 2013 (date TBD)
  • Application January, 2013
  • http//tigger.uic.edu/depts/ovcr/research/funding/
    discovery/

16
Bridge Funding Program
  • Purpose short term support to sustain research
    programs, laboratories, and momentum of
    productive researchers during funding gaps to
    give them a chance to regain extramural funding.
  • Eligibility
  • Full time (at least .8 FTE) senior faculty.
    Preference will be given to Associate Professors
  • Must have been PI on a grant funded at least
    three consecutive years (the same grant or
    project) by a national agency with a bona fide
    scientific peer-review process (e.g. NSF, NIH,
    AHA)
  • Awards Vary by Phase
  • 20K for one year or less. Must be matched 11  
  • Next deadline TBD
  • http//tigger.uic.edu/depts/ovcr/research/funding/
    Seed_Funding/ovcr_bridge.htmlawards

17
Ignite Proposal Development Program
  • Purpose Spark proposal planning or development
    process
  • Eligibility
  • Lead PI must be tenured or tenure track faculty
    and have a full-time (at least .8 FTE) UIC
    appointment
  • Project must involve 3 or more colleges.
  • Awards Vary by Phase
  • 20K for a six month term  
  • AY 2013 deadlines TBD
  • http//tigger.uic.edu/depts/ovcr/research/funding/
    ignite/

18
Office of Research Services (ORS)
  • Supports faculty from development to award stage
  • Authorized institutional representative
  • Official institutional endorsements
  • Authorizes all submissions
  • Accepts all awards
  • Negotiates all contracts
  • Government, for profit industry, not for profit
    foundations
  • Central point of coordination for all sponsored
    projects for the Chicago, Rockford and Peoria
    campuses

18
19
Internal Approvals Cross your T, Dot your I, CYA
20
ORS - Proposal Approval Form (PAF)
  • Internal routing
  • For ALL proposals
  • Tracks and documents clearances and approvals
  • Identifying information
  • Proposal Type
  • Activity and location
  • Budget information
  • Flags UIC contributions
  • Facilities and administrative (FA) distribution
  • Budget review and approval
  • Intellectual Property
  • Conflict of interest
  • Signatures
  • Authorized Representative
  • Track awards
  • Establish accounts
  • Grants database

21
Tips for completing PAF
  • Page 1
  • Project Contact should be familiar with proposal
  • Electronic submission vs. hard copy
  • UIN required for PI and all Co-Investigators if
    applicable
  • Identification of original source of funds
    (federal flow through)
  • Program name and number
  • Sponsor Information needs to be complete

21
22
Tips for completing the PAF
  • Page 2
  • Project information checklist needs to be
    completed. One selection per category (ie
    proposal, award, activity, campus)
  • Identification of budget period
  • Budget totals should match proposal budget
  • Identify any related cost share
  • Distribution of College and Dept F A
  • Compliance Checklist Check all that apply
  • Human Subjects If applicable, provide
    Institutional Review Board (IRB) number or
    identify if pending
  • Animals If applicable, requires ACC protocol
    number
  • Recombinant DNA If applicable, require IBC
    number
  • Hospital/Clinics If applicable, require
    hospital administration approval. Allow 5
    working days

22
23
Tips for completing the PAF
  • Page 3
  • Export Controls
  • Approval/Certifications
  • Conflict of Interest Certification PI including
    any Co-Investigator(s) must mark yes or no
    and sign
  • Proposal Approvals
  • PI and all co-investigators
  • Department Head
  • School/College Dean

23
24
What are Export Controls?
25
Export Controls
  • Exports are materials, technology, software and
    information sent from U.S. to foreign
    destination 
  • Can be verbal, in writing, by access to items, or
    even by providing information to a foreign
    person in U.S.
  • Federal approval must be obtained prior to the
    export of any covered equipment, materials,
    technology, software or information.
  • Exemptions include
  • Fundamental research ordinarily published, shared
  • Public domain information
  • Commonly taught scientific principles
  • Disclosure of unclassified technical data in the
    U.S. by U.S. institutions of higher learning to
    foreign FTEs

26
Documents needed to process proposal
  • Minimum documents required to process a proposal
  • Completed PAF
  • Abstract/Scope of Work
  • Budget
  • NIH Required Documents
  • Face Page
  • Abstract/Key Personnel Page
  • Budget Justification
  • Checklist
  • Detailed Budget
  • Modular Budget Page (if applicable)

26
27
Proposal Approval Process
  • Upon receipt, assigned a PAF/ Institution number
  • Proposal assigned to a research coordinator to
    review accuracy of information and compliance
  • Reviewer endorses documentation on behalf of the
    authorized institutional official, Dr. Mitra
    Dutta
  • ORS staff sends electronic notification to
    department when proposal is ready to be picked
    up
  • General turn-around time is 1-2 business days
    after ORS receives complete proposal package

27
28
Timelines for PAF Approval
  • Paper Submissions PAF materials to ORS within 3
    days of sponsor deadline.
  • Electronic Submissions PAF materials to ORS
    within 7 days of sponsor deadline

29
Things that can delay timely approvals
  • Incorrect budget calculations
  • Missing institutional signatures
  • Lack of institutional approvals

30
Reminders for your budget
  • Always consult program guidelines as they
    explain
  • What can and cannot be budgeting for
  • If there is a cap on the amount that can be
    requested
  • What indirect cost rate is allowed

30
31
Distinguishing between Gifts, Grants and
Contracts
  • Gift Unrestricted Funds
  • Grant Pledge of support for a specific project
    area, very little if any sponsor involvement and
    includes specific reporting requirements
  • Contract A legal binding agreement whereby a
    specific project outcome is expected, usually
    involves some level of sponsor involvement

31
32
Award is here . . . . Now what?
  • Award notices sent to ORS from sponsor
  • ORS highlights special terms and conditions and
    compares award to request
  • If award differs from request a revised budget is
    requested from department
  • Revised budget reviewed and approved by ORS and
    forwarded to Grants and Contracts for account
    set-up
  • Award and supporting documents sent to PI,
    business manager and Grants and Contracts

32
33
What can slow down your award?
  • No proposal/PAF form ever submitted to ORS
  • Awarded budget does not match the proposed budget
    and you dont revise budget in a timely fashion
  • The award notice is errantly sent to PI,
    Department, or Grants and Contracts and not
    forwarded to ORS
  • Lack of institutional signatures

33
34
ORS on the Web
  • Research Development
  • Search engines to find funding opportunities
  • Limited competitions
  • Intramural financial resources
  • www.research.uic.edu/funding
  • Proposal submission
  • Standard Information for applications
  • Facilities and Administrative rates (F A)
  • Sample budgets
  • www.research.uic.edu/funding

35
Contact Us Office of Research Services
  • Luis R. Vargas, Executive Director,
    lrvargas_at_uic.edu, 312-996-6150
  • Amneh Kiswani, Associate Director,
    Akiswani_at_uic.edu, 312-996-9406
  • Tony Halford, Program Coordinator,
    ahalford_at_uic.edu, 312-996-7036
  • ORS Front Desk 312-996-2862

35
36
Questions?
37
Office for the Protection of Research
Subjects (OPRS)
38
Goals of the UIC Human Subjects Protection Program
  • To ensure a comprehensive Human Subjects
    Protections Program (HSPP)
  • Utilizing the highest ethical and professional
    standards
  • Affording the highest possible protections for
    our human subjects
  • Minimize risk to subjects and
  • Maximize benefits of the research

39
What is research? Differing perspectives
40
Research
  • a systematic investigation including research
    development, testing, and evaluation designed to
    develop or contribute to generalizable knowledge.
  • 45CFR46.102(d)

41
Human Subjects
  • living individual(s) about whom an investigator
    (whether professional or student) conducting
    research obtains
  • (1) data through intervention or interaction
    with the individual, or
  • (2) identifiable private information.
  • 45CFR46.102(f)

42
Note -
  • Only activities that involve both
  • Research and
  • Human Subjects
  • are subject to the UIC Human Subjects Protection
    Program

43
So, you will be conducting Human Subjects
Research at UIC. Now what?....
44
Tip 1 Utilize Resources
  • Contact OPRS 312-996-1711 or uicirb_at_uic.edu
  • On-line Help
  • Getting Started - A Guide for Investigators and
    Research Staff
  • Link www.research.uic.edu/protocolreview/irb/gett
    ing_started.shtml

45
Getting Started Includes information about
  • Human Subjects Research
  • Key Research Personnel
  • Investigator Training requirements
  • The role of the UIC IRB
  • The types of protocol review, including
  • Determinations
  • Exemptions
  • Expedited IRB Review
  • Convened (full) IRB review
  • Others Amendments, CR, Prompt Reports
  • Decision Trees (e.g. medical record review
    research)
  • Research at the Jesse Brown VAMC
  • Tips for obtaining informed consent
  • Helpful links

46
Tip 2 Complete Investigator Training ASAP
  • Initial Investigator Training (Investigator 101)
  • On-Line via CITI or
  • In-Person
  • HIPAA Research Training (if research involves
    PHI)
  • On-Line via LMS or
  • In-Person
  • Note UIC cannot accept applications unless PI
    training has been completed and is current.
  • Link to Education and Training
    www.research.uic.edu/protocolreview/irb/education/
    index.shtml

47
Tip 3 Sign-up for the OPRS Newsletter
  • Sent electronically every other month
  • News for Investigators
  • Tips for Investigators
  • QIP Corner
  • Continuing Education Opportunities
  • UIC Data Security Policy Information
  • Archived on OPRS Web-site
  • Sign up Contact OPRS Assistant to the Director,
    Nora Cortes nreyes_at_uic.edu

48
Contact Us
  • West Side Office Room 203B, AOB,
  • 1737 West Polk Street
  • Phone 312-996-1711
  • Email uicirb_at_uic.edu
  • East Side Satellite Office (M,W 2 4 pm)
  • Room 3108A, BSB
  • Phone 312-996-7742
  • URL www.research.uic.edu/protocolreview/irb

49
Questions?
50
Office of Animal Care and Institutional
Biosafety (OACIB)
51
Office for Animal Care and Institutional Biosafety
OACIB provides administrative support for the
review and approval of research protocols
(experiments) involving animals, recombinant DNA
and infectious agents, and ensures compliance
with regulations related to the use of controlled
substances in animal and laboratory research. The
goal of the office is to facilitate the protocol
writing/review process and navigation of the
regulatory issues to ensure compliance with the
regulations for the protection and welfare of
animals, protection and safety of investigators,
and the University.
Animal Care Committee (ACC)
  • Oversight for all use of all live vertebrate
    animals in
  • Research
  • Testing
  • Teaching

OLAW/NIH USDA AAALAC SPONSOR GUIDE ILAR DEA IDPR

52
Office for Animal Care and Institutional Biosafety
OACIB provides administrative support for the
review and approval of research protocols
(experiments) involving animals, recombinant DNA
and infectious agents, and ensures compliance
with regulations related to the use of controlled
substances in animal and laboratory research. The
goal of the office is to facilitate the protocol
writing/review process and navigation of the
regulatory issues to ensure compliance with the
regulations for the protection and welfare of
animals, protection and safety of investigators,
and the University.
Institutional Biosafety Committee (IBC)
Oversight of all research involving rDNA Infectiou
s agents/toxins Select Agents (EHSO)
OBA CDC USDA
53
Office for Animal Care and Institutional Biosafety
  • Protocol approval is required prior to
  • Prior to initiation of any use of
  • animals
  • JIT or acceptance/transfer of a
  • funding award proposing the
  • use of animals
  • simultaneous with the initiation
  • of some rDNA work (e.g. in vitro
  • BSL 1)
  • prior to the initiation of some
  • rDNA work (e.g., all viral
  • vectors, use in animals, use in
  • humans)
  • prior to the initiation of all
  • infectious agent work
  • Protocols are needed if research involves the use
    of animals, rDNA, /or infectious agents and
  • is conducted at UIC, or
  • is conducted by UIC students /or
  • paid personnel, or
  • is conducted using funds
  • administered by UIC including
  • subcontracts and consortiums.


   
54
Office for Animal Care and Institutional Biosafety
  • Know what is approved on the protocol-
  • species/strains
  • specific procedures
  • specific experiments
  • specific endpoints or monitoring
  • no migration
  • Have expertise or get appropriate training in
    techniques/procedures to be performed
  • Get approval for changes prior to initiation
  • Personnel need to be listed on a protocol if they
    are
  • PI
  • PI of a grant supported by the protocol
    (must be Co-PI on the protocol. PPG, Form G
    protocol exceptions)
  • Working in any capacity with live animals or
    with rDNA/IA
  • Research Coordinators who need to receive copies
    of correspondence from OACIB related to protocol
    issues.


   
55
Office for Animal Care and Institutional Biosafety
Facilitating excellence in research at UIC
  • Protocols
  • Form A
  • Form B
  • Form C
  • Form G
  • Appendix 1a, 1b, 1c
  • Appendix 2
  • Appendix 3
  • Modifications
  • Form D
  • Training
  • ACC
  • Project Specific
  • Protocols
  • 6 weeks
  • No expedited Review
  • Vet
  • Subcommittee
  • Full Committee
  • Modifications
  • Administrative
  • - 3-7 days
  • Designated Reviews
  • - 1-6 weeks
  • Full
  • - 1-6 weeks


   
56
Office for Animal Care and Institutional Biosafety
Facilitating excellence in research at UIC
  • Protocols
  • 2 weeks
  • Prereview
  • Expedited
  • Full
  • Modifications
  • Expedited
  • - 3-7 days
  • Full
  • -1-4 weeks
  • Protocols
  • Form A
  • Form B
  • Form D
  • Appendix 1
  • BSL1 Manual
  • BSL2 Manual
  • Modifications
  • Form C
  • Training
  • BBP
  • DOT/IATA
  • Select Agents


   
57
Office for Animal Care and Institutional Biosafety
Facilitating excellence in research at UIC
  • Animal Facility
  • Orientation
  • Occupational Health
  • Card Access
  • Account Creation
  • Animal Orders
  • Approved
  • Unapproved
  • DEA Licenses
  • Modifications
  • Form D
  • Annual Renewal
  • Triennial Review
  • Lab Inspections
  • BSC Certifications
  • Modifications
  • Form C
  • Annual Training
  • Triennial Review


   
58
Web Sites
Office of Animal Care and Institutional Biosafety
  • ACC www.research.uic.edu/protocolreview/acc/index
    .shtml
  • IBC www.research.uic.edu/protocolreview/ibc/index
    .shtml
  • Controlled Substances www.research.uic.edu/protoc
    olreview/cs/index.shtml

Meeting Dates Forms Education/Training Policies
/Guidance FAQs Online Resources Contact
Information
59
Office of the Vice Chancellor for Research
Facilitating excellence in research at UIC
AAALAC
Chemicals
OBA
Controlled Substances
USDA
Humans
Toxins
Animals
Select Agents
OHSA
FDA
Lasers
OLAW
Radioactivity
X-rays
Infectious agents
rDNA
OHRP
60
Office of Animal Care and Institutional Biosafety
Regulations Pertaining to Research Animals rDNA
Infectious Agents Toxins- Biological Controlled
Substances Select Agents Humans Chemicals Radionuc
leotides X-rays/Irradiators Lasers Embryonic Stem
Cells Conflict of Time/Commitment Conflict of
Interest Import/Export Material Transfer
61
Contact Us
  • Office of Animal Care and Institutional Biosafety
  • Mary Bowman, PhD, Director
  • Room 206 AOB
  • 1737 W. Polk
  • Phone 312.996.1972
  • Email mbb_at_uic.edu

62
  • Questions?

63
Conflict of Interest (COI)
64
Conflict of Interest
65
Conflict of Interest
What is financial conflict of interest?
  • A conflict of interest arises when an academic
    staff member is in a position to influence either
    directly or indirectly University business,
    research, or other decisions in ways that could
    lead to gain for the academic staff member, the
    staff member's family, or others to the detriment
    of the University's integrity and its missions of
    teaching, research, and public service.
  • Family" is defined as one's spouse or domestic
    partner,
  • parents, siblings and children.
  • Conflicts reside in a situation, and do not
    imply
  • improper behavior.

66
Conflict of Interest
Who is covered by the policy?
  • All paid academic staff members, whether part
    time or full time, of the University of Illinois.
    The academic staff includes the faculty ranks of
    professor, associate professor, assistant
    professor (and all of the foregoing whose
    appointments contain such terms as 'research,'
    'adjunct,' 'visiting,' or 'clinical'),
    instructor, and lecturer, as well as academic
    professionals and postdoctoral associates.
  • Any paid, non-0 appointment.
  • Students, including medical residents, are not
    considered academic staff.

67
Conflict of Interest
Report of Non-University Activities (RNUA)
  • Annual Reporting of Non University Activities is
    the implementation of conflict of interest
    policies and regulations for both conflict of
    interest and conflict of commitment.
  • All academic staff complete the form, even if
    there are no outside activities to disclose.
  • 24/7 during the contract period.
  • Resolution always begins with RNUA disclosure and
    sometimes involves a combination of conflict
    management techniques.

68
Conflict of Interest
PHS FCOI Regulations (2011)
  • These regulations require HHS, PHS, and NIH
    Investigators and senior/key research personnel
    to
  •  
  • Disclose significant financial interests (SFIs)
    at the time of proposal submission
  • Disclose sponsored or reimbursed travel at the
    time of proposal submission
  • Update disclosures within 30 days of any newly
    acquired or discovered SFIs
  • Manage Financial Conflicts of Interest (FCOI)
    prior to execution of an award or continuing
    review
  • Complete mandatory University training on
    Financial Conflicts of Interest (FCOI)

69
Conflict of Interest
How to report and manage COI
  • Annual Disclosure
  • Annual Report of Non-University Activities
    (RNUA)
  • RNUA-Management Plan (RNUA-MP) for situations
    that require more management (e.g., faculty
    involved in start-up companies).
  • HHS/PHS/NIH Significant Financial Interest
    Disclosure and Management Plan Part I
  • SFI-DMP Part II when University designated
    officials determine SFI represent a FCOI
  • Transactional Disclosure
  • PAF COI Certification
  • IRB protocols applications COI section

70
Conflict of Interest
How to report and manage COI
  • Unit Executive Officer
  • Holds primary responsibility for working with
    the academic
  • staff members to manage conflicts.
  • UIC Conflict Review Committee (CRC)
  • Advisory to the Vice Chancellor for Research.
  • Reviews RNUA-management plans and other
    management plans as needed
  • COI-Human Subject Research (COI-HSR) Committee
  • Expedited review of COI disclosures on IRB
    protocols
  • Makes recommendations to the IRB.

71
Conflict of Interest
COI Resources
  • Online
  • All RNUA materials (forms, instructions, more)
  • Managing conflicts (templates, instructions,
    committee
  • info)
  • Policy, rules, regulations
  • FAQs
  • In Person
  • Phone, email help
  • Strategy, guidance, and oversight meetings
  • Educational presentations

72
Contact US
  • Jacquelyn Jancius, COI Director
  • Phone 312-996-4070
  • Email coi_at_uic.edu
  • Scott MacEwen
  • COI Coordinator
  • Phone 312-996-3642
  • Email coi_at_uic.edu
  • www.research.uic.edu/conflict

73
Questions?
74
Research Integrity
75
Research misconduct at top-tier research
institutions raise public concerns about
policing scientific integrity
  • 1970s
  • William Summerlin, Memorial Sloan-Kettering
    Cancer Center
  • the painted mice
  • 1980
  • Elias Alsabati, six different US research
    intitutions
  • gt80 plagiarized and fraudulent papers
  • Marc Straus, Boston University
  • falsified patient eligibility for clinical
    trials
  • Vijay Soman, Yale Medical School
  • falsified and fabricated data
  • plagiarized a rivals paper
  • John Long, Massachusetts General Hospital
  • falsely represented monkey cells as human

76
Fraud in Biomedical Research
March 1981 Congressional Oversight Hearings Al
Gore, Jr. , Chair, Investigations and Oversight
Committee of the House
Science and Technology Committee
Philip Handler, President of NAS The system
succeeds in policing itself Donald
Frederickson, Director of NIH no congressional
mandate for regulation of researchis necessary,
for the natural sciences contain ultimate
correctives for any debasement of the knowledge
derived from research.
77
Integrity in Research and Publication
  • Goal
  • promote compliance with the highest scholarly
    standards
  • Purpose
  • provide impartial fact-finding and fair
    adjudication of allegations of research
    misconduct
  • Policy
  • UI Policy and Procedures on Integrity in Research
    and Publication
  • http//www.vpaa.uillinois.edu/policies/Integrity
    -Policy.pdf
  • UI Policy incorporates federal regulations and
    PHS guidelines
  • 42 CFR 93 (rev. 2005)
  • http//www.gpo.gov/fdsys/pkg/CFR-2006-title42-v
    ol1/pdf/CFR-2006- title42-vol1-part93.pdf

78
  • 1985 Health Research Extension Act (Section 493)
  • HHS regulation requires that institutions
    establish
  • process to review allegations research
    misconduct
  • report investigation of alleged research
    misconduct to the federal government

79
Integrity in Research and Publication
  • Research Misconduct includes fabrication,
    falsification, or plagiarism in proposing,
    performing, or reviewing research, or in
    reporting research results.
  • Fabrication making up data or results and
    recording or reporting them
  • Falsification manipulating research materials,
    equipment, or processes,
  • or changing or omitting data or results such
    that the research is not
  • accurately represented in the research record.
  • Plagiarism appropriation of another persons
    ideas, processes, results
  • or words without giving appropriate credit
  • Does not include honest error or difference of
    opinion

80
Integrity in Research and Publication
  • Research Misconduct also includes, but is not
    limited to, the following
  • intentionally misleading or deliberately false
    reporting of credentials
  • and related information
  • abuse of confidentiality with respect to
    unpublished materials
  • misappropriation of research materials
  • evasion, or intentional failure to comply after
    notice with research
  • regulations, such as those governing conflict
    of interest/commitment,
  • human subjects, laboratory animals, new drugs,
    radioactive materials,
  • genetically altered organisms, and safety
  • any other conduct that constitutes a serious
    deviation from accepted
  • ethical guidelines and professional standards
    in scholarship
  • and research

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Integrity in Research and Publication
  • Any member of the University community who has
    information
  • related to potential Research Misconduct has a
    duty to report such
  • information to the Respondents Unit Executive
    Officer, or to the RIO
  • Members of the University community shall
    cooperate with the RIO
  • and other institutional officials in the review
    of allegations and the
  • conduct of inquiries and Investigations.
  • Institutional members, including Respondents,
    have an obligation to
  • provide evidence relevant to Research
    Misconduct allegations to the
  • RIO or other institutional officials.

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Contact US
Mark D. Grabiner, PhD Associate Vice Chancellor
for Research and Research Integrity Officer
Phone 312-996-2757 Email grabiner_at_uic.edu
Website www.vpaa.uillinois.edu/Policies/integrit
yresearch/index.cfm
83
Questions?
84
Research Resources Center (RRC)
85
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  • Assures accessibility of shared resources to all
    researchers in the UIC community
  • Serves gt1,000 investigators, 160M 013 grants
  • 8 M operating budget, 35-40 subsidy
  • 60 staff full-time PhD lab directors in each
    facility
  • Faculty Academic Directors
  • East and West Campus central facilities

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Recent Advancements
  • 12M new capital equipment since 2010
  • New Imaging Center 2 of Latest Zeiss Confocals,
    Prairie Multiphoton Scope, Vectra tissue imaging
  • JEOL ARM-200CF Aberration-corrected STEM very
    high resolution EM
  • Small animal imaging 9.4T MRI, IVIS live animal
    imager, VEVO Echo
  • 4 new Mass Specs Orbitrap Velos Pro, Agilent
    triple quad, AB Sciex 5500, 6500
  • New Genomics Center Sequenome Gene Titan HT
    Genotyping Ion Torrent, Proton Next-Gen digital
    PCR
  • Drug Discovery Center High-throughput Screening

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Center for Structural Biology
Director Yoshitaki Ishii, Technical Director
Ben Ramirez
  • NMR 600, 750, 800, 900 Mhz
  • Small molecule and macromolecular XRD, X-ray
    Crystallography
  • Biacore molecular interaction analysis
  • Analytical Ultracentrifugation, Calorimetry,
    Fluorescence
  • Production and purification of proteins


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Confocal Microscopy Facility
Peter Toth, Technical Director, Ke Ma, associate
Director
The Confocal Microscopy Facility will work to
accommodate any biological research that requires
light, deconvolution, confocal, TIRF, and/or
widefield fluorescent microscopy. State-of-the-art
imaging technology for fixed and live cells and
tissues. Imaging techniques live-cell, confocal,
FRET, FRAP, FLIP, TIRF, PhotoActivation, and real
time recording of micro- injection.
Instruments Confocals Two new Zeiss LSM710,
Zeiss 510Meta Olympus VivaView live-cell
long-term imaging system Prairie Systems
Multiphoton microscope Zeiss TIRF System Newly
upgraded total internal reflection
fluorescence high-resolution imaging of signals
near biological membranes. AIS2 automatic
microinjection system high injection rates of
1,500 cells per hour.
Newly rennovated space 2500 sq ft, microscopy
suites
Contact RRC-imaging_at_uic.edu
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ELECTRON MICROSCOPY SERVICE
Director Robert Klie, Technical Director Alan
Nichols
Scanning (SEM), transmission (TEM) and scanning
transmission (STEM) electron microscopes as well
as Raman spectroscopy and surface analysis
(XPS) Two laboratories E5, Medical Sciences
Building - SEM and Life Science TEM Room 116, SES
- Materials Science TEM/STEM, Microprobe, Surface
Analysis Raman NEW JEOL JEM-ARM200CF
TEM/STEM with cold field emission source CEOS
probe aberration corrector
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Flow Cytometry Service FCS Balaji Ganesh,
Director
  • The Flow Cytometry Service is a full service
    facility with seven flow cytometers. We provide
    flow cytometry services for analysis and sorting
    of cells, as well as training and expert
    consultation for project/experiment planning.
  • High speed sorters Beckman MoFlo new cell
    sorter soming soon
  • Bio-Rad Bio-Plex for multiplex quantitative
    assays
  • 5 flow cytometry analyzers new BD Fortessa, new
    Beckman Gallios
  • Staff
  • Jewell Graves, Lab Manager
  • Juan Chen, Research Specialist
  • Lakshmy Ganesh, Research Specialist

Bio-Rad Bio-Plex
Beckman Coulter Cyan ADP
Appointments can be made for instrument
instruction, sorts, and use of our flow
cytometers on the FCS Online scheduler
proteomics.rrc.uic.edu/flow. Raw data and
analysis files will be sent on line to with the
"MY DATA" server.
Types of analysis Immunophenotyping, DNA content,
cell cycle analysis, DNA ploidy analysis,
apoptosis, phagocytosis, intracellular pH,
calcium levels, oxidative burst, intracellular
antigen measurement, total protein, cytokine
detection, intracellular signaling and isolation
of rare cell populations including human and
animal stem cells.
Becton Dickinson Fortessa
Beckman Coulter MoFlo
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Transgenic Production Service
The Transgenic Production Service provides a
resource for investigators seeking to generate
transgenic and gene-targeted mice for their
research activities.
  • DNA Microinjection/Transgenics
  • ES Cell Microinjection/Chimeric mice
  • ES cell expansion
  • Gene Targeting in ES cells
  • Embryo Sperm Cryopreservation
  • Recovery of Pups from Cryopreserved Embryos
  • Recovery of Pups from Cryopreserved Sperm
  • In Vitro Fertilization (IVF)

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Animal Imaging and phenotyping
Preclinical MRI Facility 2,000 sq. ft. animal
imaging laboratory equipped with a new Agilent
9.4 Tesla MRI system that is able to image small
animals and samples up to 7.5 cm in diameter.
The Xenogen IVIS Spectrum in vivo imaging system
uses optical imaging technology to facilitate
non-invasive longitudinal monitoring of disease
progression, cell trafficking and gene expression
patterns in living animals.
CCVR Surgical services Trans aortic
constriction Coronary artery ligation Osmotic
plant implantation Imaging VisualSonics Vevo770
ultrasound
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Research Histology Core (RHC) Director Andy Hall
COMRB 1120
  • Services Available
  • Tissues embedded in paraffin and processed for
    sectioning
  • Training and consultation available for by phone,
    e-mail or in person.
  • Antibody testing for determination of optimal
    conditions
  • Immunofluorescence of cultured cells
  • Fluorescent or colorimetric detection of antigens
    by immunohistochemistry
  • TUNEL staining in fixed sections for apoptosis
    studies
  • Routine Hematoxylin and Eosin staining of tissue
    sections
  • Specialized stains, such as the Gomori Trichrome
    Stain
  • Sample preparation/OCT freezing for
    cryosectioning
  • Tissue preparation for electron microscopy
  • Imaging Nikon E400 fluorescent microscope
    equipped with a SPOT color camera.

3 microtomes Do your own or we do the work for
you Routine histology staining or
immuno-histochemical staining
Dual staining of Connexin 26 (green) and
cytokeratin (red) in the baboon endometrium.
Microm Vacutome Cryostat service, or can be
reserved to do your own sectioning
Immunohistochemical localization of cFOS in the
baboon endometrium visualized with DAB. Ha
Nikon Eclipse E400 Epi-fluorescence microscope,
Contact Andy Hall www.rrc.uic.edu/rhc
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Biorepository
  • Institutional resource for processing and storing
    human tissue samples for research purposes.
  • New LN and -85 freezers house blood, serum,
    plasma, urine, nucleic acids, PBMC specimens
  • IRB-approved opt-in protocol
  • Specimens are banked in compliance with
    IRB-approved protocols and HIPAA standards
  • Investigator protocols 10 current, others in IRB
  • Staffing
  • Director
  • 2 Pathologists
  • 2 Path Assistants
  • 2 Techs
  • SERVICES INCLUDE
  • Separation of whole blood derivatives serum,
    plasma, PBMCs, urine, and saliva.
  • Nucleic Acid isolation using iPrep
  • Opt-in or PI protocol all samples bar coded and
    annotated
  • Specimen management database moving from caTissue
    to OnCore
  • Secure storage of samples/data

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BioInformatics Service
Director Ives Lussier, Technical Director Neil
Bahroos
  • For analysis of big datasets from
    Genomics/Sequencing Resources
  • Integrated with Genomics, computing IT and
    Biorepository
  • Staff
  • 4 Bioinformaticians specializing in analysis of
    genome sequencing, gene expression, genotyping,
    pathways
  • Computing resources
  • Mixed cluster (GPU/CPU)
  • HPC coming soon
  • UIUC computing resources
  • New 3,000 sq ft facility in CME

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Center for Genomic Research
  • Staff Co-Directors, 8 full time technicians, 4
    students
  • Budget 1.6M/yr
  • Services
  • Next-Generation Sequencing
  • CE Sequencing
  • Quantitative analyses- QPCR
  • and Digital PCR
  • Automated Nucleic Acid purification
  • and QC
  • Gene expression analysis
  • High Throughput Genotyping, CNV
  • Cytogenomics

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Select Capabilities
  • Whole genome sequencing (De novo and
    re-sequencing)
  • Ion Torrent Proton and PGM (UIC)
  • Illumina HiSeq2000, Roche 454 (UIUC)
  • Target capture (custom/cancer panel/exome)
  • Agilent SureSelect / Haloplex (hybridization
    capture)
  • Ion Torrent Ampliseq / Qiagen Generead
    (PCR-based)
  • ChIP-seq Sample prep with Covaris acoustic
    shearing
  • Microbiome Analysis Ribosomal RNA gene
    sequencing
  • Genotyping Affymetrix Gene Titan 96 sample
    2.2M microarray
  • Sequenome 768 sample throughput
  • Transcriptome sequencing
  • Differential gene expression
  • Detection of novel transcripts
  • Illumina HiSeq / Ion Torrent Proton
  • MicroRNA Ion Torrent Proton TILDA microfluidic
    arrays
  • Quantitative mRNA expression analysis
  • Affymetrix Quantigene Plex 3 to 80-plex
    96-sample throughput
  • Affymetrix micro array
  • Cytoscan Affymetrix cytogenetic profiling

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Mass Spectrometry, Metabolomics and Proteomics
Richard van Breemen, Academic Director Alex
Schilling, Technical Director Primary Staff Rod
Davis, Jerry White
  • Other Instrumentation
  • New Triple Quad ABSciex 5500
  • Shimazdu IT-TOF MSn
  • JOEL GC-MATE MS
  • Thermo TSQ Quantum QQQ MS-MS
  • Agilent HPLC Chip Cube Interface
  • Agilent 1946C MSD MS
  • Thermo LCQDeca MSn
  • Waters SCF-MS
  • Shimazdu LCMS 8030 QQQ MS-MS
  • Agilent Off-gel
  • Thermo LTQ MSn
  • Services Provided
  • Accurate Mass Measurement
  • LC-MS and LC-MS-MS
  • MALDI MS and MS-MS
  • Quantitative Analysis
  • Structure Elucidation
  • Protein Identification
  • Metabolite Identification

Thermo LTQ-FT LC/MS/MS
Informatics Tools
  • Mascot SEQUEST search engines
  • Scaffold report generation easier to interpret,
    interact with your results
  • Self-serve informatics workstations BioWorks and
    file conversion tools
  • X!Tandem searches
  • Specialized tools, customized databases

2 Agilent 6410 Triple quads ChipCube system
Waters Synapt QTOF MS ion mobility
Thermo Velos Orbitrap Pro funded by NCRR Fitted
with Chip Cube
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Scientific Instrumentation Shop Director Eric
Schmidt

The Scientific Instrument Shop (SIS) is staffed
by Instrument Makers, Senior Laboratory
Mechanics, and Biomedical Electronics Engineers
who construct and repair all types of mechanical
and electronic/electrical equipment for the
research, teaching and clinical requirements of
faculty, staff and students.

Machine Shop Skilled Instrument Makers will
assist designing and/or fabricating items
utilizing the latest CAD/CAM software full
3-axis and 3-D contour milling. Materials
stainless and alloy steels, titanium, lead,
platinum, brass, aluminum, copper, sheet
metal plastics acrylic, acetate, acetal,
polypropylene, polystyrene, nylon, PVC, teflon,
polycarbonates, polyethylene, engineered plastics
wood, wood composites and machinable ceramics.

Electronics Shop complete electronic services
including the maintenance and repair of
electronic devices. We also design and fabricate
customized electronic equipment that may not be
commercially available.
Staff
 
Eric Schmidt Director Schmidte _at_uic.edu
Services Tig welding of most metals Brazing
silver solder Sandblasting Thermocouples
Repair and rebuilding Fabrication of parts-
most plastics machining, plastic
welding/gluing, bending and polishing
Capabilities Turning in lathe up to 15" Manual
milling 2 axes and 3 axes CNC milling Surface
grinding Precision thread cutting Sheetmetal
bending Forming, shearing and fabrication Hole
punching Woodworking sawing and fabrication
Matthew Schuck, Instrument Maker
John Grega, Biomedical Engineering Technician
101
Contact US
William Hendrickson Director, RRC Phone
312-996-5600 Email whend_at_uic.edu Website
http//www.rrc.uic.edu/
102
Questions?
103
Biologic Resources Laboratory (BRL)
104
Biologic Resources Laboratory
  • UICs Centralized Animal Research Facility
  • Oversight of the institutions animal care and
    use program
  • Support research
  • Daily care and husbandry of all laboratory
    animals
  • Procurement of all animals
  • Ensure animal welfare
  • Ensure compliance with regulatory agencies
  • Ensure the health status of animal colonies
  • Train students, staff, and faculty

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Biologic Resources Laboratory
  • UICs Animal Care and Use Program has been
    continually accredited by AAALAC International
    since 1970.
  • Oldest and most successful training programs for
    laboratory animal veterinarians
  • Active professional staff
  • Professional organizations
  • Teaching
  • Research
  • Service

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Biologic Resources Laboratory Program Scope
  • 137,000 sq. ft.
  • 10 satellite facilities
  • House over 20 species
  • Ave. daily census 32,000 animals
  • Mice 30,000
  • Primates 175

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Biologic Resources Laboratory Program Scope
  • Staff - 64
  • 11 vets 5 board certified, 6 post-docs
  • 8 veterinary technicians
  • 37 husbandry staff
  • 6 administrative staff
  • 1enrichment specialist
  • 1 machinist

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Biologic Resources Laboratory Animal Based
Research Scope
  • 275 investigators
  • 700 active research protocols
  • Types of studies
  • Cancer
  • Immunotherapy
  • Radiobiology
  • Infectious disease
  • TransplantationHeart Disease
  • Diabetes
  • Neurologic disease
  • Retinal diseases

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Biologic Resources Laboratory Services
  • To gain access to any of the facilities
  • Listed on an approved ACC protocol
  • Orientation with one of the veterinarians
  • Visit employee health and enroll in the
    occupational health and safety program

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Biologic Resources Laboratory Services
  • Centralized surgery
  • Diagnostic laboratory
  • Radiology section
  • Antibody production service
  • Cross foster rederivation program
  • Support Good Laboratory Practice Studies
  • Support bio and chemical hazard work
  • Irradiator
  • Metabolic cages
  • Rodent quarantine
  • Resource

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Biologic Resources Laboratory
  • Main phone number 312-996-7040
  • Website http//www.brl.uic.edu/
  • Key contacts
  • Fee schedule
  • Animal per diem rate
  • Diagnostic lab services
  • Surgery services
  • Jeffrey Fortman, Director Biologic Resources Lab
  • 312-996-1220
  • jdf_at_uic.edu

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Questions?
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