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Glycolysis, Krebs Cycle, and Electron Transport System

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Pyruvate (3-Carbon) Acetyl (2-Carbon)-CoA. 2 Pyruvate 2 CoA 2 NAD 2 Acetyl-CoA 2 CO2 2 NADH. Overall energy production so far... – PowerPoint PPT presentation

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Title: Glycolysis, Krebs Cycle, and Electron Transport System


1
Glycolysis, Krebs Cycle, and Electron Transport
System
  • A review for the confused (like me!)
  • Regina Lamendella
  • AP Biology
  • December 16, 2008

2
What is happening while you ingest donuts??
3
Doughnut glucose electrons
What is the purpose of glycolysis and cellular
respiration?
  • Electrons

4
Overview Video
  • Write down the major take home messages from
    the video

5
Glycolysis
  • 10-STEP reaction
  • (Rxns 1-5) Glucose is phosphorylated and cleaved
    to yield 2 molecules of triose glyceraldehyde-3-ph
    osphate. This process uses two ATPs.
  • (Rxns 6-10) The molecules of glyceraldehyde-3-pho
    sphate are converted to pyruvate, with
    concomitant generation of four ATPs and two NADH
    per glucose.
  • How many net ATPs?

6
Glycolysis
1 ATP
  • Where are we within the cell?
  • What does ATP stand for?
  • What does NAD stand for?
  • How many carbons does pyruvate have?

1 ATP
2 NAD
7
Adenosine Tri-Phosphate
8
Nicotinamide Adenine Dinucleotide
9
Nicotinamide Adenine Dinucleotide H
H
10
Overall reaction for glycolysis
  • Glucose 2 NAD 2 ADP 2 Pi ? 2
    NADH 2 pyruvate 2 ATP
  • Where do the pyruvate go next?

11
Intermediary Reaction
  • Pyruvate (3-Carbon)? Acetyl (2-Carbon)-CoA
  • 2 Pyruvate 2 CoA 2 NAD ?
    2 Acetyl-CoA 2 CO2 2 NADH

12
Overall energy production so far
  • Glycolysis 2 ATP, 2 NADH
  • Intermediate reaction 2 NADH

13
Krebs Cycle
  • Roles of the Krebs cycle
  • Generate energy by oxidizing acetyl-CoA to carbon
    dioxide and water
  • Supply biochemical intermediates for other
    pathways
  • Entry point of various degradative pathways for
    energy generation

acetyl-CoA
Squeezing the energy out of acetyl-CoA!!!
14
Krebs Cycle
  • Where are we?
  • What is ATP?
  • What is NAD?
  • What is FAD?
  • How much energy is produced?

15
FAD?FADH2Flavin Adenine Dinucleotide
H
H
?
16
Energy Production from Krebs Cycle
  • Acetyl-CoA 3 NAD ADP Pi ?
  • 3 NADH ATP 2 CO2
  • Wait we had two pyruvates to start have to
    multiply above by 2!!
  • 2 Acetyl-CoA 6 NAD 2 ADP 2Pi ?
  • 6 NADH 2 ATP 4 CO2

17
Energy Production So far
  • Glycolysis 2ATP, 2 NADH
  • Intermediate Step 2 NADH
  • Krebs Cycle 2 ATP, 6 NADH, 2 FADH2
  • Where to next?

18
Electron Transport System Video
  • Take notes and write down main points.

19
Electron Transport System
  • Electron transport chains are redox reactions
    that transfer electrons from an electron donor to
    an electron acceptor.
  • The transfer of electrons is coupled to the
    translocation of protons across a membrane,
    producing a proton gradient. The proton gradient
    is used to produce useful work.
  • NADH 3 ATP
  • FADH2 2 ATP

20
Total energy production after ETC
  • Glycolysis 2ATP 2 NADH 6 ATP
  • Intermediate step 2 NADH 6 ATP
  • Krebs 2 ATP 6 NADH 18 ATP 2
    FADH2 4 ATP
  • 34 ATP from ETC
  • 2 ATP from Glycolysis
  • 2 ATP from Krebs directly
  • Total ATP production 38 ATP
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