Title: Integrating depression detection and treatment into work with older adults
1Integrating depression detection and treatment
into work with older adults
- Peter A. Lichtenberg, Ph.D., ABPP
- Director, Institute of Gerontology
- Professor of Psychology
- Wayne State University
2Perspectives on Old Age
- To me old age is always 15 years older than I am
- Bernard Baruch, age 84
- How old would you be if you didnt know what age
you were? - Satchel Paige
3DSM-IV Major Depressive Disorder
- At least 5 of the following 9 symptoms have been
present for a 2 week period (either a or b must
be one of the 5 symptoms) - a. Depressed mood consistently - not transient
- b. Loss of pleasure and interest in normally
pleasurable activities (anhedonia) - c. Significant weight loss or gain (gt5 body
weight) - d. Insomnia or hypersomnia
- e. Psychomotor agitation or retardation
- f. Loss of energy, fatigue (even following a
good nights sleep) - g. Feelings of worthlessness, self-reproach,
inappropriate guilt - h. Decreased ability to think or concentrate
- i. Suicidal thoughts or attempt
4There is nothing Minor about Minor Depression
- MAJOR
- Depressed mood or loss of pleasure
- 4 additional symptoms
- Interfere with social or occupational function
- At least 2 week duration
- MINOR
- Same
- 1 additional symptom
- Same
- Same
5PrevalenceDepression at Late Life
- ECA data 1-month point prevalence is 10.0
- 2.3 MDD
- 2.3 Dysthymia
- 1.5 Minor Depression
- 3.9 symptoms
- 20-30 subsyndromal or minor
- depression symptoms
- 17-37 in PCCs
- Gatz and Smyer (1992) 1-year prevalence of all
mental disorders (gt64) at 20-22. - Comorbidity of anxiety disorder for an MDD
presentation is 35-45
6Prevalence of Major Depression in Older Adults By
Setting
0 5 10 15 20
Primary Care
Nursing home
General hospital
Assisted Living
Home Health Care
Community
7Depression Detectionin Primary Care
- Major issue in geriatric primary care
- 24 mos. study of HMO enrollees2Mean age 75, 62
women - 16 prevalence of depression
- 48 undetected
- Least detected Men 64-75 and all gt 85
8ABCs of Depression
A Affect Apathy Feelings of worthlessness Sadness, anger
B Behavior Sleep, appetite Social functioning Fatigue, agitation
C Cognition Negative thoughts Lack of concentration
J Fam Prac 03 S13
9Major negative impacts of depression
- Pre-mature mortality
- Increased physical disabilityone of leading
causes in world - Link btwn depression and subsequent cognitive
decline - Lower quality of life
- Poorer relations with others/social
network/support
10Depression Etiology
11Depression Etiology Biological
- Neurotransmitters
- Serotonin
- Norepinephrine
- Dopamine
12Neurotransmitters and Mood, Cognition, Behavior
Serotonin Norepinephrine Dopamine
Mood Mood Mood
Anxiety Anxiety Attention
Obsessions Alertness Pleasure
Compulsions Energy Reward
Panic Pain Motivation
Worry Apathy
Energy
13Neurotransmitter Function
14Pathophysiology
- Neurochemical
imbalance - Serotonin
- Norepineprine
- Dopamine
15Results of SSRI Clinical Trials
- Effective in older adultsbut not that much more
than placebo - SSRI limitations
- Use of physically healthy elders
- Major differences are side effects, not efficacy
- Liver side effects a concernespeciallyin elders
16SSRIs
Prozac 20 mg
Zoloft 50 mg
Paxil 20 mg Paxil CR 25 mg
Celexa 20 mg
www.drugs.com
17SNRI
Cymbalta 20 mg
Effexor 25 mg
Effexor XR 75 mg
www.drugs.com
18SARI
Serzone 50 mg
Trazodone 50 mg
Serzone 100 mg
19NDRI and NaSSA
Wellbutrin 75 mg
Remeron 30 mg
Wellbutrin SR 100 mg
20Antidepressant Side Effects
Tricyclics SSRI SNRI NDRI SARI/NaSSA MAOI
Dry mouth Nervousness Nausea Agitation Nervousness Drowsiness Weakness
Blurred vision Agitation Loss of appetite Weight loss Nausea Dry mouth Dizziness
Constipation Insomnia Anxiety Nervousness Headache Nausea Headache
Difficulty urinating Headache Headache Blurred vision Loss of appetite Weight loss Dizziness Trembling
Worsening glaucoma Nausea Insomnia, bad dreams, tiredness Insomnia Liver problems (serzone)
Impaired thinking Dry mouth Dry mouth Constipation Inc blood pressure Orthostasis Food interactions
Tiredness Diarrhea Sexual dysfunction Dry mouth Constipation Muscle pain
Inc blood pressure Sexual dysfunction Inc heart rate Inc blood pressure Seizures Weight gain
Orthostasis Inc heart rate Platelet dysfunction Inc cholesterol Constipation
21Increasing reliance on meds with little evidence
to support it
- Response yes, remit no
- Antidepressant use doubled from 1996 (5) to
10.4 in 2006 switch from 2 or gt meds increased
from 42 in 1997 to 60 in 2006 3 meds from 16
to 33 (Olfason et al., 2006)
22Placebo and You2nd Generation Antidepressants
- Acute phase, parallel group, double blinded,
placebo controlled with random assignment, for
2nd generation antidepressants not associated
with a med disorder and 60 or gt. Cochrane and
Medline - 10 unique trials with 13 contrasts (N2377 active
drug and 1788 placebo) - Response rates for Drug 44.4
- Response rate for Placebo34.7
- 10-12 weeks gt 6-8 weeks
- Discontinuation rates highest for Drug.
- 2nd generation meds work but effects are modest
and vary. - For every 100 treated, 8 show a response and 5
remission in excess of placebo - TCAs perform about the same as 2nd generation
meds - Placebo rates vary 19-47. Lots of
heterogeneity Nonspecific effects -
Nelson et al., 2009
23Vascular Depression Hypothesis
- Vascular diseases can predispose, precipitate,
or perpetuate a depressive syndrome in many
elderly patients Alexopoulos9
24Vascular disease can cause microvascular brain
tissue damage in frontal/subcortical areas of
brain
- Diabetes
- Atrial Fibrillation
- Hypertension
- Smoking
- Obesity
- High cholesterol
25Development of Depressive Disorders
- Hypertension, Diabetes, CAD, Stroke
Genetics, Neurological Disease, Stroke, Etc.
Frontal Striatal Lesions
Vulnerability To Depression
Life Events
Social Support
Depressive Disorders
Model of Risk Factors That Lead to Depressive
Disorders Adapted from Krishnan KRR. Biol
Psychiatry. 2002 52 185-192
26Vascular Burden Study(Mast, MacNeill
Lichtenberg, Amer J Geriat Psychiatry, 2004)
- Sample
- 680 consecutively admitted geriatric rehab
patients (age 60) - Separated into 3 groups
- Stroke Pts with evidence of stroke, n205
- CVRF Pts with CVRFs but no stroke, n353
- Non-vascular Pts with no stroke or CVRFs, n122
27Hypotheses
- Prevalence of depression will be greater among
patients with vascular disease (stroke and CVRFs)
than among non-vascular medical patients. - Prevalence will not differ between stroke and
CVRF groups.
28Results H1
- Prevalence and severity of depression did not
differ significantly among the 3 patient groups.
29Results H1Vascular Burden
- Presence of 2 CVRFs was associated with
increased prevalence of depression in the
non-stroke group.
30Conclusions from Study
- Concept of vascular burden
- Replication in sample of 600 community dwelling
elders (Yochim, Mast Lichtenberg 2003)
31Case StudyVascular Depression
- 78 YO WM recently retired Diabetes, heart
disease - Depression evident but physical limitations keep
him from travelling the way he wants to - At age 80 begins falling, exhaustion, lower
energy expenditure (frailty) - Falls and dies at age 82
32Activity Limitation TheoryChange in activities
mediates relationship between medical condition
and depression.
Activity Restriction
Depression
Illness, Pain
33Depression FunctionExercise Interventions
- Interventions
- Weight-lifting 20 wks v lectures 10 wks20
- 13 major 17 minor depressives, mean age 71
- Follow-up at 20 weeks and 26 months
- Aerobics v resistance v education, 3 mos21
- 439 knee osteoarthritics, mean age 69 22 scored
above BDI cutoff - Follow-up at 3 months and 18 months
34Depression FunctionExercise Interventions
- Results
- Both aerobic and resistance exercise reduced
depression, disability, pain - Exercise more effective than education
- Compliance best for low depression groups
- Adherence to exercise declined over time
35Case Study
- 81 year old womanhealthy until enters hospital
for acute kidney failure - Dx. Multiple Myeloma
- Chemotherapy
- Depression evident
- Treatment works and allows her to return to
gardening and hiking - Depression disappears
36Lewinsohnian Model of Depression
- Feelings and behavior are linked
- Three decades of research support the behavioral
model for persons including - Young, middle-aged, older adults
- Caregivers
- Demented elders
37Behavioral Treatment of Depression
- Rationale
- Goal
- Techniques
- What the person does is related to how s/he
feels - To increase positive events and decrease negative
ones - Relaxation, mood monitoring graphing
38The Retirement Research Foundation-Institute of
Gerontology Project
- Integrating Mental Health in Occupational Therapy
Practice with Older Adults - Cathy Lysack Peter Lichtenberg (PIs), plus team
of WSU experts in aging, and community partners.
39(No Transcript)
40The DVD Box Set
- 1. Introduction, Aging and Mental Health
- 2. Understanding and Treating Depression
- 3. Medications for Treatment of Depression
- 4. Family Caregiving
- 5. Falls, Balance and Exercise
- 6. Driving Rehabilitation and Community Mobility
- Plus
- - A CD with assessments, powerpoint slides, and
references/resources in pdf format. - - A DVD with video of full patient assessments.
41Behavioral Activation
- Combines meaningful activity and pleasant events
- Teaches patients that mood is related to what
they are doing - Does not require a big time investment to
integrate into treatment
42Elements of Behavioral Activation
- Mood ratings
- Rationale
- Pleasant event Brainstorming
- Identify barriers to implementation
- Commit to making a change
43Attitudes about talking with older adult clients
about mood
- Older adults are resistant to talking about their
mood or sadness? - Pre Post (True response)
- 53 16 (30 OTs in training group)
- 45 (112 OTs in one day conference
- Combined data (144 OTs)
- 40 did not know diagnostic criteria for
depression - 33 overestimated amount of depression in
population they work with - These were statistically significant changes
plt.05
44Performance Indicator Descriptive Data
Table 1 Demographic information N All Patients
Age (years) 384 80.1
Gender (female) 384 69.2
Heart Disease 384 49.2
Diabetes Mellitus 384 29.2
Dementia 384 19.0
CVA 384 11.8
Depression 384 10.5
Medications for depression or anxiety 384 19.2
High levels of comorbidity
45 Table 2 Performance Indicators Pre-training (n 199) Post-training (n 184)
Mention of mood or depression 66.3 77.7
Depression screening 3.0 25.3
Reporting mood to treatment team 25.5 31.5
Referral to other health professional 7.5 13.7
Mention of pleasant events or behavioral activation 9.0 16.1
Report mood ratings of patient 6.0 11.8
Identify pleasant events 5.6 15.0
Get commitment from patient to attempt events 4.1 8.6
Mention of cognitive functioning 70.0 88.8
Cognitive screening 11.1 39.0
Report cognitive functioning to treatment team 24.5 34.3
Referral to other health professional because of cognitive functioning 5.6 6.1
Mention of caregiver 46.7 38.8
Report on coping/stress of caregiver 2.6 5.9
Referral of caregiver to sources of help 7.3 12.0
plt.05 plt.01
Performance Indicator Change Data
46Case Study
- 80 YO live alone woman, falls fractures hip
- OT administers MLDTmild cognition problems,
mild-moderate depressive sx. - Interviews woman about enjoyable activities
- Discovers woman loves to be read to and discuss
poetry - Depression recedes and woman makes gains and can
return home
47Wordens Four Tasks of Grief
- Accept the reality of the loss
- Work through the pain of grief
- Adjust to the environment in which the deceased
is missing - Emotionally relocate the deceasedand move on
with life
48Bereavement
- Bereavement 800,000 people/year bereavement (20
MDD) Key What is depression what is abnormal
grief and what is OK? - Complicated Bereavement V Code
- Yearning for, preoccupation for, searching
for, excessive crying, disbelief regarding death
and non-acceptance of death, as well as social
isolation. Global functioning suffers. - Must generally return to pre-loss activities
- Assess for depression and the above
variables - Texas Revised Inventory of Grief (26 items,
0-65) - Inventory of Complicated Grief (18 items
and score 25 or gt)
49Grief and Depression
- Depression as a typical complication of grief29
- 13.9 of newly bereaved had depressive symptoms
after 2 years v 4 of married persons - Percent of newly bereaved with depressive
symptoms by month (no gender difference)
50Early Loss and Late Life Expression in Poor Elders
- 109 older-old African Americans
- 51 of respondents lost parentto death or
desertion by age 16 - Those with parental loss had
- Decreased education, social resources, and family
satisfaction - Increased depressive symptoms
51Case Study
- 78YO woman loses husband and leg (below knee) in
same month (diabetes) - Enters psychotherapy
- Excessive guilt, searching, waiting for husband
to returnfor months - Works through issues surrounding fathers death
- Begins to get active and convinces adult children
to get jobs and help care for her
52Assessment, referral and how to
- Screening for depression is important
- Communicating with the clinical team is key
- Understanding basic approaches to intervention is
helpful
53MLDT Emotional Status Measure GDS-3
- Do you feel pretty worthless the way you are now?
- Do you feel that your life is empty?
- Do you often feel downhearted and blue?
54MLDT GDS-3 Decision Making
- If just one GDS-3 item is answered
- YES,
- A complete evaluation for
- depression is recommended
55Items from the Geriatric Depression Scale Items
1-5
- Are you basically satisfied with your life?
- Have you dropped many of your activities and
interests? - Do you feel that your life is empty?
- Do you often get bored?
- Are you in good spirits most of the time?
56Items from the Geriatric Depression Scale Items
6-10
- Are you afraid that something bad is going to
happen to you? - Do you feel happy most of the time?
- Do you often feel helpless?
- Do you prefer to stay home rather than going out
and doing something? - Do you feel you have more problems with memory
than most?
57Items from the Geriatric Depression Scale Items
11-15
- Do you think it is wonderful to be alive?
- Do you feel pretty worthless the way you are now?
- Do you feel full of energy?
- Do you feel your situation is hopeless?
- Do you think most people are better off than you
are? - GDS score greater than or equal to 5 raises
suspicion as to depression
58Communicating results of screening
- Integrated Care and its role in treating older
adults
59Integrated Care
- Interdisciplinary Health Care that emphasizes a
high degree of collaboration in - Patient evaluation
- Treatment planning
- Outcome evaluation
602007 American Psychological Association
Presidential Task Force
61Individual Assessments
Shared information Team goals Intervention plan
strategies
Individual Delivery of Care
62Practice Models
- Fully Integrated Care - part of treatment team
coordinated behavioral and medical care (i.e.
response to illness, Rx develop/ situational
issues, management chronic) - Consultant Model evaluation physician
consultation, brief interventions - Co-Location Model- essentially specialty mental
health care in same location as primary care
63Case for Integrated Care
- Supported research evaluations- integrated care
more sessions, than enhanced referral (Bartels et
al, 2004) - Evidence studies of reduced symptoms, improved
life quality (see Aredin, 2003 Skultety Zeiss,
2006) - Reduced stigma and increased knowledge re
behavioral health