Large neuroblastoma showing patchy necrosis and haemorrhage excised surgically from a female aged 16 months

1

• Large neuroblastoma showing patchy necrosis and
  haemorrhage excised surgically from a female aged
  16 months
• occur within the adrenal medulla

2

• Relatively mild acute pancreatitis.
• The pancreas appears mildly congested and foci of
  calcification (arrows) are present within the
  gland

3

• Severe acute haemorrhagic pancreatitis.

4
The main changes occurring in pancreatitis are

• Protease digestion of pancreatic substance
• Elastase digestion of blood vessels with
• subsequent haemorrhage
• Lipases digesting fat in the pancreas and in the
  peritoneal cavity
• Accompanying inflammatory reaction

5

• Acute pancreatitis. The pre-existing architecture
  has been essentially destroyed
• Haemorrhage and necrosis of acute pancreatitis,
  with some preserved pancreatic parenchyma on the
  left

6

• Focal acute necrosis of perirenal fat in a
  patient who had severe acute pancreatitis.
• The patient was oliguric due to acute renal
  tubular necrosis of ischaemic type.
• See the calcium deposition (arrows) highlighting
  foci of enzymatic fat necrosis.

7

• Severe chronic pancreatitis in a male alcoholic
  aged 45

8

• Chronic pancreatitis with atrophy of the exocrine
  component and replacement by fibrous tissue.