EDNOS

1
????? ???????????? ??????"? ??? ????, ??????
??????? ?????, ?????????? ?? ??????, ???? ???
??????? ????, ??????????, ??????????? ??????
????????
2
?? ??? ?????? ??????
3

• ???????? ??????
• ?????? ??????
• EDNOS
• (Eating Disorders Not Otherwise Specified)

4
?????? ????? ?? ????????

• Subclinical AN/BN
• Binge-eating disorder (BED)
• Night eating syndrome
• Purging (w/o bingeing)
• Chewing and spitting
• Orthorexia
• Muscle dysmorphia (reverse anorexia)
• Diabulimia (insulin deprivation in type I
  diabetes)
• PICA (consumption of non-food items)

5
?????????? ????????? ?????? DSM-IV

• ???? ???? (???? ?-85 ??
• ???? ???? ?????)
• Body Mass Index (BMI) weight in kg
• 
  (height in m)2
• ??? ?????? ????? ??-?????
• ????? ????? ??? ????? ?? ???? ???? ???????
• ??????? (????? ?????? ??????)

6
???-????? ?? ???????? ??????

• Binge-eating/purging ????? ????? ?/?? ?????,
  ????? ????????, ??????, ??????, ????? ????? ???

• Restricting ?????, ???, ?????? ?????? ??????

7
??????? ?? ???????? ??????

• ????? ????? ????
• ?????? 0.3 - 0.5
• ?? 10 ???? ??????
• ???? ???? ??? ????? ???? ????????

8
????????
AN
9
?????????? ??????? ?????? DSM-IV

• 1) ????? ????? (????????)
• 2) ??????? ????
• 3) 1) ?-2) ????? ?????? ????? ???? 3 ??????

10
???-????? ?? ?????? ??????

• Purging ???????? ????? ?????, ???????,
  ??????, ??????, ??????

• Non-purging
• ???????? ????? ???, ?????? ?????? ??????

11
??????? ?? ?????? ??????

• ????? ?????? ????
• ?????? 3-4
• ?? 10 ???? ??????
• ??? ????? ????? 15-21

12
????????
BN
13
????? ????? ??????? ?????
?????
????
14
???????? ?????? ?????? ???????

• ?????-???????
• ????????
• ????????
• ???????????

• ??????
• ?????????
• ?????????
• ??????????

?????? ?????????
15
?????? - ???? ????
16
?????? - ?????? ?????? ?????????

• ???? ????? ?????? ???? ???? ????? ??????
• ???? ?????? ????? ????? (???, ???, ???'?)
• ???? ?????? ?? ???? ??????? ?????? ??????
• "???? ??????"

17
?????? - ?????? ?????? ???????, ?????????,
???????, ???????? ????????
Mary-Kate Olsen
Karen Carpenter
Jane Fonda
18
????????? ?? ???????? ?????? ?????? ?-50-80
19
?????? ?????? ?? ?????????
Genes load the gun by creating behavioral
susceptibility such as perfectionism or the drive
for thinness. Environment then pulls the
trigger. Walter H. Kaye, M.D.
"????? ?????? ?? ????? ?"? ????? ?????? ?????????
??????? ???? ???????????? ?? ???? ?????. ??????
??? ?????? ?? ????".
20
?????? ?????????

• ???????????
• ??????????
• ??? ???????
• ????? ????? ?????
• ?????? ????

AN
BN

• ????? ????? ?????
• ???? ?????? ????
• ???????? ?????

• ????? ????? ?????
• ?????, ????? ????
• ???????? ?????

21
???? ????? ???? 1
???
22
??????????? ??? ???? ??????

• ???? ??????? ?? ?????? ?????? ???????
• ??? ????? ?? ???????? ?????? ???? ???? ???????
• ????? ???
• ????? ?????????

23
??? ?????? ?? ????? ????? ??"??

• ????????
• ????? ??????
• Relative risk for AN 7-12 for women
• 20 for men

24
??? ?????? ?????????
????? ?????? MZ ?????? 100 ?????? ????? DZ
?????? ?????? 50 ??????
25
Klump et al., 2003
26
?????? ?????????

• ???? ?? ??????? ???????? ??"? ???? ???
• Nature Vs. Nurture
• ????????? ??????????

27
????? ????????? (association studies)

• ????? ????????? ????? ?????? ??? ?????? ??????
  ???????? ?? ???????? ??????? ??? ??????.

28
????? ??????? ????

• ????? ????????? ????? ???? ??????? ????? ??????
  ??????? ???????? ???????? ??????? ?? ????? ??????
  ????.

29
(No Transcript)
30
(No Transcript)
31
??????? ?? ????? ?????????

• ????? ??????
• ?????? ??????
• ???? ?????? ??????

32
????? ?????? (Linkage analysis)

• ???? ???????? ?????? ?????? ??? ???????? ????
  ???? ?????? ???????????.
• ?? ??, ??????? ??????? ?????? ?????? ?????????
  ???? ???-???? ?????? (restrictive) ?? ??????,
  ???????? ???????? ?????.

33
Grice et al., 2002
34
????? ??? ????? ????????? ????? ???????????
???? ?????? ????? ?????? ?????? ??? ????? ??????
?????????? (???? ?????) ?? ????????? (??????????,
????) ????????? ?????? ?????. ???? ?? ????? ????
????? "???? ??????" ??????, ?? ??? ???????? ?? ??.
35
???? ???????????
?????????? ?????? ????? ?????? ??? ??? ????
????? ????
36
?????? ???????

• ????? ????? ?????
• ????? ?????? ?????
• ?????? ???? ??????
• ????? ?????? ??????? ???????

37
(No Transcript)