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Metabolism of Nucleotides

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Title: Created Date: 3/22/2001 6:43:47 AM Document presentation format: Other titles: Times New Roman Tahoma ... – PowerPoint PPT presentation

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Title: Metabolism of Nucleotides


1
? ? ?
? ? ? ? ?
Metabolism of Nucleotides
2
???
  • ?????????
  • ?????????
  • ??????5-???????
  • ?????????

3
? ?
?????
?????
????
4
????
5
  • ?????????????????????????????????,?????????
  • ????DNA??????,?RNA?????

6
????????
  • ?????????
  • dATP ? dGTP ? dCTP ? dTTP
  • DNA?????
  • ATP?GTP?CTP?UTP
  • RNA??????
  • ?????????ATP?GTP(?????)?UTP(????)?CTP(????)

7
  • ??????????cAMP?????,???????????AMP?ADP?ATP???????
    ?
  • ????????????NAD?FAD???A??
  • ????????UDPG?CDP-????SAM?PAPS??

8
(No Transcript)
9
  • ???????
  • ????
  • ??????
  • (de novo synthesis pathway)
  • ??????
  • (salvage synthesis pathway)
  • ????

10
  • ??????(de novo synthesis pathway)
    ????????????????CO2 ????????,?????????,?????????
  • ?????????
  • ????????

11
  • ??????(salvage synthesis pathway)
    ??????????,?????????,?????????
  • ?????????
  • ?????????????

12
??? ????????
Metabolism of Purine Nucleotides
13
  • ????????

AMP
GMP
14
????????????
  • ??????
  • (de novo synthesis pathway)
  • ??????
  • (salvage synthesis pathway)

15
(?)??????????
  • ??

??????????????????????????????????????????,???????
??,???????????
  • ????

??????????????????,????????,????????????????
16
  • ??????????

CO2
???
????
??? (????)
??? (????)
???? (???)
17
  • ??

1. IMP???
2. AMP?GMP???
18
PP-1-R-5-P(PRPP) (???????)
R-5-P (5-????)
H2N-1-R-5-P(PRA) (5-?????)
  • ???? ???N
  • N10??????
  • ????a-??N
  • ???
  • ????

IMP
19
(No Transcript)
20
1?IMP?????
??
?
?
?
?
? GAR??? ?????? ? FGAM??? ?AIR???
21
(No Transcript)
22
IMP???????
23
IMP?????
  • ???????????????
  • PRPP?????????,???????????????,????????????????????
    ???????5-?????????
  • PRPP??????????????

24
2?AMP?GMP???
  • IMP?AMP?GMP????

25
??????????? ?IMP??? ??????????? ?GMP???
? ?
26
ATP?GTP???
???
27
???????????
  • ???????????????????
  • PRPP?????????,???????????????,???????????????????
    ????????5-?????????
  • PRPP?????????????
  • IMP????5?ATP,6???????
  • AMP?GMP?????1?GTP?1?ATP?
  • AMP?GMP??????????

28
???????
  • ??
  • ?????,??????
  • ??ATP?GTP????

? ?
29
  • ???????

?????????????
PRPP
PRA
GTP
? ?
30
(?)????????????
  • ??

??????????????,???????,??????????,??????(?????)??
?
31
  • ????????

?????????? (adenine phosphoribosyl transferase,
APRT) ????-??????????(hypoxanthine- guanine
phosphoribosyl transferase, HGPRT) ????(adenosine
kinase)
32
  • ????

APRT
??? PRPP
AMP PPi
HGPRT
??? PRPP
GMP PPi
33
??????????????AMP
  • ??????

????(adenosine kinase)
34
?????????
  • ????????????????????????
  • ????????,???????????????
  • HGPRT??????????????

35
HGPRT????Lesch Nyhan ???
????-??????????(HGPRT)???????????????????,????????
????,?????????????
??????????(hyperuricemia)??????????,????????
36
(?)??????????
37
(?) ??????????
4?NDP(A?G?C?U)???????4????dNDP
38
????????
39
  • ??????????

40
  • ??????????????,??R1?R2???????R1?R2??????????DNA
    ???????????????,???????????????

41
  • ?????DNA?4?????????????,????????????????????,??
    ????????????

42
(?) ??????????
  • ????????????????????????????

????? ?????? ?????
6-???? 6-????? 8-?????? ?????? ??? ?????
43
?????
44
  • 6-MP????????????6MP???,????????IMP???AMP?GMP???
  • ?????????,??????-??????????(HGPRT),?PRPP??????????
    ???????????,??????????

45
??????
46
  • ??????????
  • ?????Gln???
  • ???Gln????????????,?????????????

47
?????
???
????
Aminopterin, AP
Methotrexate, MTX
48
  • ???????????(MTX)??
  • ?????????????,????????FH2?FH4??????????????????,??
    ???????????

49
? ?
50
?????????
dADP
dATP
AMP
ADP
ATP
IMP
GMP
GDP
GTP
dGDP
dGTP
51
????????????
????
???
??
Pi
??????
??
1-????
52
?????????????????????????
? ?
53
(No Transcript)
54
I (????)
AMP
??????
X (???)
GMP
G
??????
?????? ????
55
  • ???????????????????????????
  • ?????????????????????????

56
??? ???????? ,???????
????????????
???????????,????HGPRT?PRPP???????PRPP??????(GPAT)?
??-6-???(G6PC)???????(XDH)?
57
  • HGPRT??????,????????????,???IMP?GMP?GDP??,????????
    ??????PPRTK?GPAT????,??????????????
  • ??-6-??????,G-6-P??????????,G-6-P?????????????5-?
    ???,????PRPP????
  • ?????????????????????,??10???????????

58
??????????????????????????0.120.36mmol/L?????????
??????????????0.64 mmol/L?,????????????????????,??
???????????????????????????(gout)?
59
????????
  • ????????(allopurinol)???????????

60
  • ?????
  • ????????,?????????????????????????????,??
    ???
  • ??
  • ???????
  • ??????

61
???????????
Metabolism of Pyrimidine Nucleotides
62
????????
63
????????????
  • ??????
  • ??????

64
(?)??????????
  • ??

????????????????????????????????????????,?????????
,???????????
  • ????

????????
65
  • ?????????

Gln
CO2
66
  • ????

1. ?????????
67
(No Transcript)
68
(No Transcript)
69
2. ?????????
UDP
UTP
70
3. dTMP?TMP???
dUMP
??????? dTMP
71
???????
ATP CO2 ????
??????
????
????????
?????
ATP 5-????
PRPP
UMP
?????
UTP
CTP
72
(?) ??????????
73
?????????
CDP
74
(?)??????????
1.????????????????,????????????????????????????,
????????????????. 2.???????

75
  • ????????5-????(5-FU)

76
  • ??????
  • ????????CTP????
  • ?????
  • ?????????dUMP????????????dTMP?

77
  • ???????????????
  • ???????CDP???dCDP,???DNA????

78
?????
????
????
?????
79
????????????
80
????????
81
?????????
82
???
????
NH3
???
ß-?????
?????
H2O
H2O
CO2 NH3
ß-???
ß-?????
?
?????CoA
???????CoA
??
??CoA
???CoA
TAC
???
TAC
83
?????
  • 1. ??(1)??????
  • (2)??????
  • (3)????????
  • 2. ???????
  • (1)IMP ? AMPS ? AMP
  • (2)IMP ? XMP ? GMP
  • (3)UTP ? CTP
  • (4)dUMP ? dTMP

84
  • 3. AMP C6?GMP C2?CTP C4????dTMP C5??????????
  • 4. ???????????????????????????????????
  • 5. ??PRPP????????????

85
  • 6. ????????(CPS)????????
  • 7. ????????????????????????????????????
  • 8. ???????????????????????????
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