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Tips%20on%20writing%20a%20manuscript%20for%20peer-review

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Tips on writing a manuscript for peer-review Stephen Durham Section Allergy and Clinical Immunology NHLI, Imperial College London EAACI Barcelona – PowerPoint PPT presentation

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Title: Tips%20on%20writing%20a%20manuscript%20for%20peer-review


1
Tips on writing a manuscript for peer-review
  • Stephen Durham
  • Section Allergy and Clinical Immunology
  • NHLI, Imperial College London

EAACI Barcelona Tues 10th June 2008
2
Assumptions
  • Target audience
  • 2nd-3rd year research student working
  • on a translational project in allergy
  • - protocol driven
  • - background known
  • - literature search ongoing
  • - references available

3
Tips on writing a manuscript for peer-review
Have a system and write back to front
4
Time course of biomarkers during immunotherapy
2 weeks
IL-10 production
Grass pollen count
Change in response
late phase response
0
2
4
6
8
12
16
20
24
28
32
36
40
44
48
52
Duration of allergen immunotherapy (weeks)
J Allergy Clin Immunol 2008 121(5)1120-1125
5
Time course of changes in IL-10 and
IgG-associated inhibitory activity
Time course of biomarkers during immunotherapy
Late allergen-induced Skin Response
4 weeks
Grass Pollen season
Change in response
0
2
4
6
8
12
16
20
24
28
32
36
40
44
48
52
Duration of allergen immunotherapy (weeks)
late phase response
J Allergy Clin Immunol 2008 121(5)1120-1125
IgG4
IgE-FAB inhibition
Change in response
Pollen count
8 weeks
Early skin response
0
2
4
6
8
12
16
20
24
28
32
36
40
44
48
52
Duration of allergen immunotherapy (weeks)
6
The system
  • Have all data available before you start to write
  • Decide target journal and read instructions for
    authors
  • Draft figures to illustrate key findings
  • Write legends to figures
  • Draft tables subject data, results/stats
  • Write legends to tables
  • Draft results.
  • Write discussion (4-6 paragraphs)
  • Write methods (do not duplicate fig/table
    legends)
  • Write introduction
  • Add references
  • Write abstract
  • Write title
  • Authors/acknowledgements/conflicts of interest

7
Tips on writing a manuscript for peer-review
  • Have all data available before you start to write
  • Decide target journal and read instructions for
    authors
  • Draft figures (usually 3-4) to illustrate key
    findings
  • Write legends to figures
  • Draft tables (usually 2) subject data,
    results/stats
  • Write legends to tables
  • Draft results.

8
Tips on writing a manuscript for peer-review
  • Have all data available before you start to write
  • Decide target journal and for authors
  • Draft figures to illustrate key findings
  • Write legends to figures
  • Draft tables subject data, results/stats
  • Write legends to tables
  • Draft results. Do not duplicate figures/tables

9
Figures
  • Simple
  • Illustrate main findings
  • - clinical data
  • - lab data
  • - Micrographs/Facs plots etc to illustrate data
  • Do not include figures of hypotheses etc for
    peer-reviewed m/s

10
Clinical response to Grass IT
11
Antibodies after Grass SCIT
12
Legends
  • Short unless journal requests methodology in
    legends
  • Do not include lengthy details of pts or methods
  • Identify all symbols fully
  • Check numbering!

13
Tables
  • Demographic data
  • Detailed data and stats to allow
    validation/replication of results
  • Uninformative data
  • Negative data

14
Subject data
15
Main data in detail with statistics
Table 2
16
Tips on writing a manuscript for peer-review
  • Have all data available before you start to write
  • Decide target journal and read instructions for
    authors
  • Draft figures (usually 3-4) to illustrate key
    findings
  • Write legends to figures
  • Draft tables (usually 2) subject data,
    results/stats
  • Write legends to tables
  • Draft results.
  • Write discussion (4-6 paragraphs)

17
Results
  • Lay out hard copies of figures, tables and
    legends and describe them!
  • Use plain English
  • Simple
  • Short sentences
  • Factual
  • Illustrate rather than duplicate data in
    figures/tables
  • No statements of interpretation

18
Discussion (6-8 paragraphs)
  • 1. Recap results emphasise novelty/importance
  • Punchline - last sentence of first
    paragraph
  • 2. Defend study/methods acknowledge limitations
  • 3 Put in historical context
  • 4. Emphasise biological/clinical relevance
  • 5. Practical implications
  • 6. Future studies/ Summary

19
Tips on writing a manuscript for peer-review
  • 7. Draft results.
  • 8. Write discussion (4-6 paragraphs)
  • 9. Write methods (do not duplicate fig/table
    legends)
  • 10. Write introduction
  • 11. Add references
  • 12. Write abstract
  • 13. Write title
  • 14. Authors/acknowledgements/conflicts of
    interest

20
Methods
  • Participants
  • Statement of ethical approval and consent
  • Study design
  • Clinical protocols
  • Details of practical procedures
  • Laboratory methods
  • State ALL sources of reagents
  • Statistical analysis (include power calculation)
  • Sufficient information to reproduce all methods

21
Introduction
  • Background
  • Importance of problem
  • Hypothesis
  • Aims/overview of study (very short)

22
References
  • Check journal style
  • Ensure consistency and accuracy
  • Use SOURCE references
  • Proof read and double check
  • (can be collected and listed anytime, but add
    only at this stage)

23
Tips on writing a manuscript for peer-review
  • 7. Draft results.
  • 8. Write discussion (4-6 paragraphs)
  • 9. Write methods (do not duplicate fig/table
    legends)
  • 10. Write introduction
  • 11. Add references
  • 12. Write abstract
  • 13. Write title
  • 14. Authors/acknowledgements/conflicts of
    interest

24
Abstract
  • Check Journal requirements
  • (150-250 words)
  • Background/rationale
  • Aims
  • Methods
  • Results
  • Summary/conclusions

25
Title
  • Format/content essential for citation index
  • Short
  • Include key words
  • Main message
  • - definitive
  • - inclusive
  • - NOT descriptive alone
  • - WORSE a bland statement of intent

26
Time course of biomarkers during immunotherapy
2 weeks
IL-10 production
Grass pollen count
Change in response
late phase response
0
2
4
6
8
12
16
20
24
28
32
36
40
44
48
52
Duration of allergen immunotherapy (weeks)
J Allergy Clin Immunol 2008 121(5)1120-1125
27
Finally!
  • 13. Title
  • 14. Authors
  • - (?joint 1st ?joint last authors)
  • - acknowledgements
  • - conflicts of interest
  • - get independent review before submission.

28
The system
  • Have all data available before you start to write
  • Decide target journal and read instructions for
    authors
  • Draft figures to illustrate key findings
  • Write legends to figures
  • Draft tables subject data, results/stats
  • Write legends to tables
  • Draft results.
  • Write discussion (4-6 paragraphs)
  • Write methods (do not duplicate fig/table
    legends)
  • Write introduction
  • Add references
  • Write abstract
  • Write title
  • Authors/acknowledgements/conflicts of interest
  • Anticipate reviewers comments stalking horses
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