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Bottom(s) Up! A biological approach to behavioral genetics

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Bottom(s) Up! A biological approach to behavioral genetics Two Approaches to Human Genetics The Wellcome Trust Case Control Consortium Is Behavior Different? – PowerPoint PPT presentation

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Title: Bottom(s) Up! A biological approach to behavioral genetics


1
Bottom(s) Up!A biological approach to behavioral
genetics
2
Two Approaches to Human Genetics
Melancholia
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4
The Wellcome Trust Case Control ConsortiumIs
Behavior Different?
14,000 Cases 3,000 Controls
5
WGAs of Schizophrenia
MCH major histocompatibility complex HIST1H2BJ
histone PRSS16 serineprotease 16 PGBD1 piggyBac
transposable element derived 1 NOTCH4
notch4 NRGN neurogranin TCF4 transcription
factor 4
6
Many SNPs of Small Effect Size Contribute to
Risk for SCZ
n 8,537 16,124 23,563
31,029 37,655
7
Power in Association Studies
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Make the Effect Large
9
Focus on Anorexia Nervosa
  • Defined by diet restriction - weight lt85 ideal
    BMI
  • female risk gtgtgt male risk
  • Onset during adolescence
  • High comorbidity with anxiety disorders
  • Accompanied by obsessive, rigid, perfectionistic
    personality traits
  • Strong resistance to re-feeding (food phobia)
  • SSRIs not effective in underweight state, can
    prevent relapse and treat anxiety/personality
    traits.

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Fear learning model of Anorexia Nervosa
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Focus on the Serotonin Transporter
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Messenger RNA produced from the SERT gene is
processed into two forms
rs3813034 0.45 in Caucasians
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Gender difference in vs. Forms of
SERT
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rs3813034 genotype influences vs.
forms of SERT
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vs. Forms of SERTVary Across Development
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SSRIs Increases the vs. Form of SERT
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60 Diet Restriction as a Model of Anorexia
Nervosa
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Diet Restriction induces the vs.
Form of SERT
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Revisiting the vs. Forms of SERTin
the Fear Learning Model of Anorexia Nervosa
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