Neuromuscular%20Pharmacology - PowerPoint PPT Presentation

View by Category
About This Presentation
Title:

Neuromuscular%20Pharmacology

Description:

... - released from adrenal medulla in response to symp. activation Other Neurotransmitters: neuropeptide Y, vasoactive intestinal polypeptide (VIP), enkephalin, ... – PowerPoint PPT presentation

Number of Views:94
Avg rating:3.0/5.0
Slides: 17
Provided by: uwi58
Learn more at: http://mutuslab.cs.uwindsor.ca
Category:

less

Write a Comment
User Comments (0)
Transcript and Presenter's Notes

Title: Neuromuscular%20Pharmacology


1
Neuromuscular Pharmacology
59-291 Section 2, Lecture 1
2
Drugs change the function of Nervous System
  • Neurotransmitters
  • Synthesis
  • Storage
  • Release
  • Inactivation
  • Neuronal uptake
  • Receptors
  • Activate
  • block

3
Short preganglionic
Long postganglionic
Thoracic/ lumbar spinal chord
Discharge as a unit
High post pre fiber ratio
4
Short postganglionic
Long preganglionic
Cranial nerves some from the sacral spinal chord
Discrete activation of specific target
tissues Low post pre fiber ratio
5
Sympathetic and the Parasympathetic NS have
opposing effects on organ function
rest digest
Fight or flight
6
P
S
7
P
S
8
Neurotransmitters and Receptors Acetylcholine
(Ach)- in all autonomic parasymp. Junctions pre
and post ganglionic Norepinephrine (NE)- Symp.
post ganglionic neuroeffector juncion Epinephrine
(E)- released from adrenal medulla in response to
symp. activation
Other Neurotransmitters neuropeptide Y,
vasoactive intestinal polypeptide (VIP),
enkephalin, substance P, NO, seretonin, ATP
9
Receptors for Ach, NE, and EP
  • Cholinergic receptors
  • Muscarinic (M)
  • Binds and activated by muscarine
  • Para sympathetic neuroeffector junctions
  • Nicotinic (N)
  • Activated by nicotine
  • Found in all autonomic ganglia and somatic
    neuromuscular junctions
  • Adrenergic receptors
  • Receptors for EP and NE
  • Sympathetic neuroeffector junctions
  • Two types
  • a (a1, a2 ) Mediates smooth muscle contraction
  • b (b1 and b2) Mediates smooth muscle relaxation
    and cardiac stimulation

10
(No Transcript)
11

Choline acethytransferase
Nerve stimulation calcium influx
Removed by cholinesterase
()
Cholinesters (Direct acting) Bethanechol Pilocarp
ine
Cholinesterase inhibitors Indirect- acting
12
Tyrosine hydroxylase
Neuronal blocking agents block synthesis, storage
and release
DADopamine NE Norepinephrine MAO Monoamine
oxidase COMT Cathecol-O-methyltransferase
13
Mechanism of physiological response by
direct-acting sympathomimetics. D, Drug NE,
norepinephrine.
14
Mechanism of physiological response by
indirect-acting sympathomimetics. D, Drug NE,
norepinephrine.
15
Mechanism of physiological response by
mixed-acting sympathomimetics. D, Drug NE,
norepinephrine.
16
(No Transcript)
About PowerShow.com