Exploratory research project, funded by CNCSIS, program PN II

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Exploratory research project, funded by CNCSIS,
program PN II Idei Title Multilayer Hybrid
Nanoparticles. Synthesis, Characterisation,
Properties and Potential Applications in
Supramolecular Chemistry, Biochemistry,
Catalysis. Director Dr. Petre Ionita Lenght
01.10.2007-30.09.2010
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Budget
NR. CRT DENUMIRE CAPITOL BUGET 2007 (lei) 2008 (lei) 2009 (lei) 2010 (lei) TOTAL (lei)
1. PERSONELL 27000 108000 87000 114700 336700
2. Institute 14600 58400 34456 38544 146000
3 MOBILITIES 4538,83 19997,75 16022 11076 51634,58
4. LOGISTICS 26861,17 105602,25 34802 18400 185665,42
5. TOTAL 73000 292000 172280 182720 720000
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Summary The project aims the obtaining of
nanometric size hybrid assemblies by controlled
synthesis these assemblies are made by
successive deposition of different concentric
layers of organic or inorganic type on a metallic
core (gold) or on metal oxide core (iron oxides).
Each layer (including the core surface) may be
functionalized in a different (individual) way,
leading thus to a spatial (regional) accumulation
of the significant properties in a cumulative
way, it may be possible that a co-operation
between different layers to led to new
interesting properties, leading to the
acquisition of nanomaterials with remarkable
multifunctional properties. We aim also the
labeling of such materials with different organic
compounds, with optical, fluorescence,
complexing, paramagnetic and biological active
compounds. The multilayer hybrid nanoparticles
will be characterized by different general
physico-chemical measurements (UV-Vis, IR, NMR,
TEM) and also by particular measurements (as
function of the label, such as fluorescence,
magnetism, etc.). The properties of the new
hybrid multilayer nanoparticles will be studied
involving them in different physical, chemical or
biological processes, using the methods and the
procedures of supramolecular chemistry,
biochemistry and heterogeneous catalysis. Joining
together different properties and different
behaviors (as each layer has its own
characteristics) open the way of interesting
applications of these materials.
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• Objectives
• 1. Synthesis of gold, magnetite and hematite
  nanoparticles
• 2. Deposition of a silica layer on these
  nanoparticles
• 3. Derivatization of the hybrid nanoparticles
  with different (bio)chemical compounds
• 4. Involvement of the hybrid derivatized
  nanoparticles into different (bio)chemical
  processes.

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Team
Name Birth date Job Ph. D.
Petre Ionita 1967 CS II yes
Luminita Patron 1947 CS I yes
Elena Gabriela Ionita 1969 Reseacher yes
Gabriela Marinescu 1972 CS III yes
Daniela Culita 1979 Reseacher student
Marioara Bem 1977 Reseacher student
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CV Petre Ionita The Director of this project
gain his organic chemistry license from
University of Bucharest in 1992 in 1993 he
enrolled into a Ph. D. program at Polytechnic
University of Bucharest, defending his thesis
(Diphenyl-picryl-hydrazyl derivatives as modeling
compounds in interphasic acid-base and redox
processes) in 1997 since his license till today
he is working in the Institute of Physical
Chemistry. Advanced knowledge in Structural
physico-chemical investigations (UV-VIS, IR, NMR,
EPR, MS, CV, HPLC, GC, Chromatography. Organic
synthesis of free stable radical. Spin labeling
of gold nanoparticles. Laboratory experience and
main areas of research interests -organic and
analytical skills -synthesis of free stable
radicals and diradicals -generation of
short-lived and of persistent free
radicals -electronic paramagnetic resonance
(EPR) -spin-trapping of short-lived free
radicals -unconventional nitration,
ipso-substitution and mechanistic
studies -spin-labeling and labeling with stable
isotopes -experience with spectro-chemical and
physico-chemical analysis -interphase transport
of cations, protons, electrons, and amino-acids
using crown compounds -pKa determinations -extr
action and molar ratio determination of
supramolecular complexes -experimental and
theoretical determination of lipophilicities -chr
omatographic techniques (TLC, RPTLC) -spin-labele
d nanoparticles. 1. C. Ghica, P. Ionita, J. Mat.
Sci, 2007, 42, 10058-10064. 2. P. Ionita, F.
Tuna, M. Andruh, T. Constantinescu, A. T.
Balaban, Aust. J. Chem., 2007, 60, 173-179. 3. P.
Ionita, Free Radic. Res., 2006, 40, 59-65. 4. V.
Chechik, P. Ionita, B. C. Gilbert, A.
Caragheorgheopol, H. Caldararu, H. Wellsted, A.
Korte, Faraday Discuss., 2004, 125, 279-91. 5. P.
Ionita, A. Caragheorgheopol, V. Chechik, and B.
C. Gilbert, J. Am Chem. Soc., 2002, 124, 9048-9.
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CV Patron Luminita Over 112 papers, 13 patents
(5 in use), 1 book, 1 monography, over 20
national and international conferences. Gas-croma
tography and complexes chemistry. Synthesis and
characterization of mono- and poly-nuclear
compounds. Coordinative chemistry and application
of patents in practical purposes. Oxidic
materials and precursors in complex coordinative
chemistry. 1) Daniela C. Culita, G. Marinescu,
L. Patron and N. Stanica, Rev. Roum. Chim., 2006,
51(6), 503-508. 2) G. Marinescu, L. Patron,
Daniela C. Culita, C. Neagoe, C. I. Lepadatu, I.
Balint, L. Bessais and C. Bazil Cizmas, Journal
of Nanoparticle Research, 2006, 8(6),
1045-1052. 3) D. Gingasu, I. Mîndru, L. Patron,
O. Carp, D. Matei, C. Neagoe, I. Balint, J.
Alloys Compd., 2006, 425, 357-361. 4) O. Carp, D.
Gingasu, I. Mîndru, L. Patron, Thermochim. Acta,
2006, 449, 55-60. 5) Daniela C. Culita, L.
Patron, V. S. Teodorescu, I. Balint, Journal of
Alloys and Compounds, 2007, 432, 211-216.
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CV Elena Gabriela Ionita 1993-2002, University
of Pitesti since 2002 researcher at Institute of
Physical Chemistry Bucharest. Expertise EPR,
IR, UV-Vis spectroscopy, cyclic voltammetry, TLC,
organic synthesis, cyclodextrins, spin labelling.
International fellowships - NATO/Royal Society
(2004-5) Spin-Labelled Cyclodextrins Novel
Supramolecular Receptor/Reporter Units at York
University, UK -September December 2005, Royal
Society -Short visit fellowship (York
University, UK) -February-August 2006, study
visit at York University CEEX 2/2005 -COST P15
STSM, January-March 2007 (York University, UK),
COST P15 STSM June 2007, (Institute Weizmann,
Rehovot). 1. Gabriela Ionita, Viorica Meltzer,
Elena Pincu, Victor Chechik, Org. Biomol. Chem,
2007, 5, 1910. 2. Victor Chechik, Gabriela
Ionita, Organic Biomolecular Chemistry, 2006,
3(17), 3505. 3. Gabriela Ionita, Victor Chechik,
Organic Biomolecular Chemistry, 2005, 3(17),
3096. 4. Agneta Caragheorgheopol, Horia
Caldararu, Gabriela Ionita, and Florenta Savonea,
Langmuir 2005, 21, 2591 5. Gabriela Ionita, V.
Sahini, J. Incl. Phenom. Macrocycl. Chem., 2004,
50, 183.
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CV Gabriela Marinescu Bucharest University
degree-Faculty of Chemistry (1996), master
(1997), Ph. D. diploma (2003). Post-doctoral
fellowship, France (2005-2006) other short
visits (several months) in France and Spain. 24
published papers. Competence Thermo-chromism.
Reactions in solid state. Poly-nuclear complexes.
Synthesis of complex homo- and hetero-polynuclear
derivatives (poly-metallic self-assemblies).
Poly-metallic supramolecular architectures.
Advanced materials, nanomaterials synthesis and
characterization. 1) G. Marinescu, M. Andruh, M.
Julve, F. Lloret, R. Llusar, S. Uriel, J.
Vaissermann, Cryst. Growth Design 2004, 5,
261-267. 2) L. Patron, O. Carp, I. Mindru, G.
Marinescu, N. Stanica, I. Balint, J. Serb. Chem.
Soc., 2005, 70(8), 1049-1056. 3) Daniela C.
Culita, G. Marinescu, L. Patron and N. Stanica,
Rev. Roum. Chim., 2006, 51(6), 503-508. 4) G.
Marinescu, L. Patron, Daniela C. Culita, C.
Neagoe, C. I. Lepadatu, I. Balint, L. Bessais and
C. Bazil Cizmas, Journal of Nanoparticle
Research, 2006, 8(6), 1045-1052. 5) G. Marinescu,
S. Ferlay, N. Kyritsakas, Mir W. Hosseini, Dalton
Transction, 2008, in press.
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CV Daniela Culita Design and Synthesis of
Coordination Compounds Supramolecular Chemistry
Synthesis of functionalized iron oxide
nanoparticles for biomedical applications. 1.
Daniela C. Culita, L. Patron, V. S. Teodorescu,
I. Balint, Journal of Alloys and Compounds, 2007,
432, 211-216. 2. G. Marinescu, L. Patron, Daniela
C. Culita, C. Neagoe, C. I. Lepadatu, I. Balint,
L. Bessais and C. B. Cizmas, Journal of
Nanoparticle Research, 2006, 8, 1045-1051. 3.
Daniela C. Culita, G. Marinescu, L. Patron and N.
Stanica, Rev. Roum. Chim., 2006, 51(6),
503-508. 4. Daniela C. Culita, L. Patron, G.
Marinescu, T. Constantinescu, R. Alexandrova and
G. Rashkova, Rev. Roum. Chim., 2005, 50(9-10),
745-749. 5. J. Stoyloff, R. Alexandrova, Daniela
C. Culita, L. Patron and S. Ivanov, Experimental
Pathology and Parasitology, 2005, 8/3, 3-12.
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• CV Marioara Bem
• Professional experience
• the supramolecular chemistry areas (catalysis
  through interphase transfer), fine synthesis of
  organic compounds (through SNAr and SN2
  mechanism), the projection of structural
  molecular design for specific physical-chemical
  properties (dynamic and covalent chemistry)
• purifycation of organic compounds (selective
  extractions, preparative chromatography)
• physical-chemical characterizations (UV-Vis,
  IR, 1H- and 13C-NMR, experimental determination
  of hydrophobic/hydrophilic balance by HPTLC and,
  the calculation of this properties respectively
  using the influence parameters of the different
  molecular groups.
• 1. M. Bem, F. Badea, C. Draghici, M.T. Caproiu,
  M. Vasilescu, M. Voicescu, A. Beteringhe, A.
  Caragheorgheopol, M. Maganu, T. Constantinescu
  and A.T. Balaban, Arkivoc, 2007, XIII, 87-104.
• 2. M. Bem, M.Vasilescu, M.T.Caproiu, C. Draghici,
  A. Beteringhe, T. Constantinescu, M.D. Banciu,
  A.T. Balaban, Central European Journal of
  Chemistry, 2004, 2(4), 672-685.
• 3. M. Bem, M.T. Caproiu, M.Vasilescu, M. Tudose,
  R. Socoteanu, A. Nicolae, T. Constantinescu and
  M.D. Banciu, Revue Roumaine de Chimie, 2003,
  48(9), 709-715.
• 4. M. Bem, M.T. Caproiu, D. Stoicescu, T.
  Constantinescu and A.T. Balaban, Central European
  Journal of Chemistry, 2003, 3, 260-276.
• 5. M. Bem, D. C. Culita, M.T. Caproiu, T.
  Constantinescu and M. D. Banciu, Revue Roumaine
  de Chimie, 2003, 48(5), 387-392.

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Results
No. Journal Year Vol. Pages
1 Mat. Sci. (Poland) 2007 25 1011-1017
2 J. Inorg. Organomet. Polym. 2008 18 414-419
3 Rev. Roum. Chim. 2008 53 439-445
4 J. Mat. Sci. 2008 43 6571-6574
5 Arkivoc 2008 xiv 158-165
6 Org. Biomolec. Chem. 2009 7 598-602
7 J. Inorg. Organomet. Polym. 2009 19 228-233
8 Rev. Roum. Chim. 2010 55 131-135
9 Phys. Chem. Chem. Phys. 2010 12 6956-6960
10 Mat. Chem. Phys. 2010 122 491-495
11 Chem. Comm. 2010 46 8255-8257