Monitoring Milestones in Patients With Chronic Myeloid Leukemia

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Monitoring Milestones in Patients With Chronic
Myeloid Leukemia
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Activity Goal
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Treatment Milestones
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Workup Patient Newly Diagnosed in Chronic Phase
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Definition of Response in CML
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Definition of Response in CML (cont)
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Response Milestones Frontline Imatinib in
Chronic Phase CML
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Faster Responses With Nilotinib and Dasatinib
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Prediction of Outcome Based on the 3-month Time
Point
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BCR-ABL/ABL lt 10 by IS at 3 Months Predicts
Outcome
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What Are the Options When the 3-month Time Point
Has NOT Been Reached?
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At 3 Months, BCR-ABL of 10 IS Identifies
High-Risk Patients
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Retrospective Analysis of CML Study IV MMR and
CCyR at 3 Months
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Considerations for the 3-month Time Point
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Conclusions
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Monitoring at the 6-Month Time Point
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Monitoring at the 6-month Time Point
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Rise and Fall of BCR-ABL Transcript Levels With
Imatinib Dosing
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Retrospective Analysis of CML Study IV MMR and
CCyR at 6 Months
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Monitoring at the 12-Month Time Point
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12-month Follow-up
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12-month Follow-up (cont)
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12-month Follow-up (cont)
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12-month Follow-up Relapse
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Algorithm for Modulating Risk Factors
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BCR-ABL KD Mutations Before and After Imatinib
Therapy
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Conclusions
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Monitoring Patients at the18-Month Time Point
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Monitoring at the 18-month Time Point
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Event-free Survival by Response
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Monitoring at the 18-month Time Point
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Treating Patients With Mutations in the Second
Linea,b
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Results With Second-/Third-Generation TKI After
Imatinib Failure/Resistance
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Cytogenetic Relapse at 18 months
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Best Molecular Response
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