Safety and Efficacy of Neratinib (HKI-272) in Combination with Paclitaxel in Chinese Patients with ErbB-2 Metastatic Breast Cancer - PowerPoint PPT Presentation

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Safety and Efficacy of Neratinib (HKI-272) in Combination with Paclitaxel in Chinese Patients with ErbB-2 Metastatic Breast Cancer

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Title: Safety and Efficacy of Neratinib (HKI-272) in Combination with Paclitaxel in Chinese Patients with ErbB-2 Metastatic Breast Cancer


1
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  • ?????????????

2
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  • ??
  • 30?
  • 35?
  • 40?50?

3
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Ries LAG, Melbert D, et al. SEER Cancer
Statistics Review, 1975-2005, National Cancer
Institute. Bethesda, MD, http//seer.cancer.gov/cs
r/1975_2005/, based on November 2007 SEER data
submission, posted to the SEER web site, 2008.
4
50?????????
Jeong KK, Beom SK, Jung SL, et al. Do Very Young
Korean Breast Cancer Patients Have Worse Outcoms?
Annals of Surgical Oncology, 2007.14(12) 3385-91
5
Breast Cancer in Young Asian Women
Number of new breast cancer patients diagnosed
per 100,000 of the young populations in Asian
countries
10 14 yr 15 19 yr 20 24 yr 25 29 yr 30 34 yr
Pakistan (1995 1997) 1.2 6.3 14.0 48.4
Israel (Jews) 0.1 0.2 2.1 9.7 33.3
Singapore 6.3 29.9
Egypt 0 1.4 8.5 29.9
Bahrain 0 0 0 27.7
China (Beijing 1993 1997) 0.7 3 11 26.9
Kuwait 0 0 2.9 22.7
Philippines (Manila) 0.1 0.5 1.9 8.2 22.1
Jordan 0 0.8 6.5 21.7
Mali 0.5 1.9 2.9 8.5 21.7
Oman 1.9 2.9 8.5 21.7
Korea (Seoul) 0.3 1.5 6.1 17.3
Japan (Nagasaki) 0.4 1.8 3.1 16
Thailand 0.4 1.2 4.8 15.2
Vietnam 0.9 7.6 11.5 13.8
Agarwal G, et al. World J Surg.
2007311031.1040.
6
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  • Higher Percentage of young patients than in
    Western countries
  • 50 of patients are premenopausal
  • Higher percentage of ER negative patients than in
    Western countries
  • 40-50 are ER negative

Fan L et al., Breast cancer Res Treat. 2009
7
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  • ???????,????,????,??,??,?????????????,??
  • ????BRCA-1?BRCA-2?????

8
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  • ??????????????,????????????,???????????? 1,2
  • St. Gallen ????????????35????????????????????????

1.Jeong KK, Beom SK, Jung SL, et al. Do Very
Young Korean Breast Cancer Patients Have Worse
Outcoms? Annals of Surgical Oncology,
2007.14(12) 3385-91 2.Han W, Kim SW, Park LA,
et al. Young age an independent risk factor for
disease-free survival in women with operable
breast cancer. BMC Cancer, 2004, 482-89.
9
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  1. ???????,????????????????,????????????????????????
    ?????
  2. ??????????
  3. ???????,?70???????
  4. ???????????????????????????

Nancy Klarber. Tumor biology of breast cancer in
young women. Breast Dis.2005 (23)9-15
10
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  1. ???CerbB2(????26-44)?ER????(????39-80)
  2. ??S???????P53?Ki-67?????
  3. ???????????????30????????34?????,???????14-16

Nancy Klarber. Tumor biology of breast cancer in
young women. Breast Dis.2005 (23)9-15
11
????????? ??????(1)
  • ?????????
  • ??????? ?????????????????????????????????
  • ??????????????
  • 6??CMF??????80-9040????30-40
    40?????????4??AC??40?????40????????????50-60?10
    -15?

12
????????? ??????(2)
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  • ???????????????????
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13
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14
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  • ??????????(BCT)??? ??(LR)????????
  • (1)??????????????,?
  • ????,??????
  • (2)??????

15
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?????(LR)
???? 50
????? 33.3
???? 20.8
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16
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?????(LR)
?????? 5?LR??19.5???10.2
???? lt49??????????????????LR????38,?gt50?????LR??????22?
17
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  • ????????BCT??????????????
  • ????????????????????????????BCT??????LR??
  • ?????BCT????!

18
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?? ??() ?? ()
?? lt50, ER?? (n 1,398) 40 7 35 9
Age lt50, ER?? (n 1,115) 33 8 20 10
Age ?50, ER?? (n 3,240) 30 5 17 6
Age ?50, ER?? (n 6,793) 18 4 9 5
Early Breast Cancer Trialists Collaborative
Group. Lancet. 1998352930-942.
19
?????30?????????????
???? 5????() 10????() P?
? 44.1 30.9 0.05
? 62.3 41.5 0.05
???,???. ??????, 2005, 27(2) 111-113
20
P0.007
21
?????????(OvS)?????
??
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??
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  • ER?????
  • ER?????
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  • OvS TAM?RFS??
  • ???
  • ???

CMF vs Surgery CMF vs XRT CMF vs OvS
CMF vs OvS CMF vs OvS CMF vs OvS
TAM CMF vs OvS TAM FAC vs OvS TAM FEC vs OvS
TAM
Scottish Scandinavian ZEBRA IBCSG
VIII TABLE GROCTA 02 ABCSG 5 French FASG 06
22
????????30?????????????
???????? 5????() 10????() P?
? 58.4 45.0 0.03
? 86.7 63.7 0.03
???,???. ??????, 2005, 27(2) 111-113
23
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  • ?ER??????, ??????15??????11.8,?????9.2
  • ????????????????????????

EBCTCG. Lancet 2005 365 1687-1717
24
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  • ??????(CK5/6?17?)?EGFR ?????
  • ?????,???
  • ????????BRCA1?????????????, 80 ????????BRCA1??

25
??TNBC???????
  • 1999?1??2007?12???TNBC??94?,??????786?????????12.0
  • ????????????? (86.2)???????IV??????
    ?(8.1?51.1?29.8?1.0????? 14.9

??,???. ??????,2010
26
??TNBC?????
  • 1?3?5?7?DFS???88.3?66.9?59.7?59.7,OS???98.9?8
    5.6?72.9?69.6
  • ???????????,???????TNBC???????(Plt0.05)

??,???. ??????,2010
27
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  • ????(Avastin )
  • PARP ???

28
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29
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30
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31
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32
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  • ??????????0.23.8
  • ????70???30???
  • ??129?30???????,?????????24.8
  • ???????????????????,????????,???????
  • ????????

???,???. ??????, 2005, 27(2) 111-113
33
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34
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35
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