Excess Oxalate Warning

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Excess Oxalate Warning
2
Foods that Enhance Oxalate Excretion

• Wheat Bran
• Beets
• Chocolate
• Nuts
• Tea
• Spinach
• Swiss Chard
• Strawberries
• Rhubarb

• Avoid excesses of these in green drinks if prone
  to kidney stones.
• Calcium inhibits absorption.
• Massey, Linda K., et al., Effect of dietary
  oxalate and calcium on urinary oxalate and risk
  of formation of calcium oxalate kidney stones,
  Journal of the American Dietetic Association,
  August 1993 93(8)901-906.
• 36 patients with recurring oxalate kidney stones
  were supplemented with 200 mg Mg and 10 mg B6 for
  5 years. 30 had no recurrence or decreased stone
  formation.
• Gershoff, Stanley, et al., Effect of daily MgO
  and vitamin B6 administration to patients with
  recurring calcium oxalate kidney stones, Am J
  Clin Nut, May 1967 20(5)393-399.

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Organic vs Commercial Agriculture
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Polyphenols vs. Flavonoids

• Flavonoids (4,000)
• Anthocyanins
• Flavonols
• Flavanones
• Flavonols
• Flavones
• Isovlavones

• Polyphenols (8,000)
• Flavonoids (4,000 )
• Phenolic acids
• Stilbenes
• Tannins
• Diferuloylmethanes

• All flavonoids are polyphenols but not all
  polyphenols are flavonoids. Flavonoids are the
  largest family of polyphenolic compounds. The
  names are often used interchangeably.

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Suggested Biological Effects of Polyphenols

• Antimutagenicity
• Anticarcinogenicity
• Antiaging

• Antibacterial
• Antiviral
• Anti-inflammatory
• Antiallergic
• Antithrombotic

Velioglu, Y.S., et al., Antioxidant activity and
total phenolics in selected fruits, vegetables,
and grain products, J. Agric. Food Chem.,
1998464113-4117.
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Polyphenol Loss with Conventional Farming

• Organic grapes were shown to have 2 times the
  levels of polyphenols found in conventional
  produce. This increasemay contribute
  effectively to disease resistance in organic
  farming (ie. less pesticide use)
• Nunez-Delicado, Estrella, et al., Effect of
  organic farming practices on the level of latent
  polyphenol oxidase in grapes, Journal of Food
  Science, 200570(1). Web Publication.

• All organic peach samples showed a highly
  significant (Pgt0.01) increase in polyphenols
  compared with conventional peaches.
• Carbonaro, Marina and Mattera, Maria,
  Polyphenoloxidase activity and polyphenol levels
  in organically and conventionally grown peach and
  pear, Food Chemistry, March 2001 72(4)419-424.

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Total Phenolics

• the total phenolic (TP) content of
  marionberries, strawberries, and corn grown by
  sustainable, organic, or conventional cultural
  practices were measuredStatistically higher
  levels of TPs were consistently found in
  organically and sustainably grown foods as
  compared to those produced by conventional
  agricultural practices.
• Asami, Danny K., et al., Comparison of the Total
  Phenolic and Ascorbic Acid Content of
  Freeze-Dried and Air-Dried Marionberry,
  Strawberry, and Corn Grown Using Conventional,
  Organic, and Sustainable Agricultural Practices,
  Journal of Agriculture and Food Chemistry, Jan
  25, 2003511237-1241. 

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Flavonoids in Tomatoes

• Ten-year mean levels of quercetin and kaempferol
  in organic tomatoes were 79 and 97 higher than
  those in conventioal tomatoes, respectively. The
  levels of flavonoids increased over time in
  samples from organic treatments, whereas the
  levels of flavonoids did not vary significantly
  in conventional treatments.
• Barrett, Diane M., et al., Ten-year comparison of
  the influence of organic and conventional crop
  management practices on the content of flavonoids
  in tomatoes, J. Agric. Food Chem.,
  2007556154-6159.

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Carpal Tunnel Syndrome

• A pinched nerve in the wrist which causes
  numbness, tingling and other symptoms in the hand
  and arm.

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Carpal Tunnel Syndrome

• Karl Folkers and John Ellis identified a
  deficiency of vitamin B6. Improvement takes place
  in 10-12 weeks when adequate B6 and co-factors
  (including B2) are supplied (generally about 50
  mg.).

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B Complex Deficiency

• General Causes
• Genetic and epigenetic defects -- At least 5
  metabolic abnormalities that respond to vitamin
  B6 supplements have been reported.
• Competitive antimetabolites bind more tightly
  to the receptor site than the vitamin.
• Noncompetitive antimetabolites -- can not be
  driven away by the vitamin.
• Acquired Dependency

• B6 antagonists
• Food coloring (Yellow 5)
• Herbicides
• Plant growth regulators (growth inhibitor on
  potatoes onions ripening agents)
• Prescription medications (birth control pill)
• Hydrazines (rocket fuel, smoking, medications for
  TB, depression, high blood pressure)
• PCBs
• Overheated vegetable oils

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Mauve Factor or HPL
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HPL or Mauve Factor

• Correlates with emotional and oxidative stress
• Associated with intestinal permeability.
  Prednisone provokes.
• Antibiotics reduce suggesting bacterial
  overgrowth is involved in its production or the
  production of a precursor.
• Zinc and vitamin B6 reduce urinary excretion
• McGinnis, W.R., et al., Discerning the Mauve
  Factor, Part 1, Altern Ther Health Med, Mar-Apr
  200814(2)40-50. (Part 2 May-June)

HPL is unstable outside the body and destroyed by
light.
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Mauve Factor HPL

• Schizophrenics
• Acute first admission 90
• Acute first and readmissions 75
• Treated still ill 50
• Treated and well 0
• Now identified as HPL (hydroxyhemopyrrolin-2-one)
  
• Misidentified in the literature as kryptopyrrole
• Inversely associated with vitamin B6 and zinc
  levels in red blood cells
• Causes abnormal perception
• McGinnis, W.R., et al., Discerning the Mauve
  Factor, Part 1, Altern Ther Health Med., Mar-Apr
  200814(2)40-50.

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Neurobehavioral Disorders associated with
Elevated HPL

• Down syndrome 71
• Adult sudden deviance criminal behavior 71
• Youth violent offenders 33
• Manic depression 47-50
• Non-schizophrenic depression 12-46
• Autism 46-48
• Epilepsy 44
• ADHD 40-47
• Alcoholism 20-84
• Substance abuse 75

Signs of B6 and Zinc Deficiency Poor dream
recall, morning nausea or anorexia White spots on
nails, stretch marks
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Vitamin D and Brain Function
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Vitamin D and Brain Development

• vitamin D acts as a neurosteroid with direct
  effects on brain development.
• Eyles, D.W., et al., Developmental vitamin D
  deficiency causes abnormal brain development,
  Psychoneuroendocrinology, 20093455247-5257.

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B Complex and Folic Acid
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Folic Acid Detoxification of Arsenic Alcohol
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Infertility Heart Disease
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Omega-3 and Diabetes
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Omega-3 in Diabetes and Obesity

• Derivatives of omega-3 fatty acids are important
  regulators of inflammation in obesity and
  diabetes. These compounds prevented and even
  reversed the effects of diabetes in obese mice.
• Hammock, Bruce D., et al., Inhibition of soluble
  epoxide hydrolase modulates inflammation and
  autophagy in obese adipose tissue and liver Role
  for omega-3 epoxides, PNAS. Cristina
  López-Vicario, doi 10.1073/pnas.1422590112

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Cancer Research
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Omega-3 Cancer

• A product of metabolized DHA, an omega-3 fat,
  helps combat cancer by cutting off the supply of
  oxygen and nutrients that fuel tumor growth and
  the spread of the disease. The product is called
  epoxy docosapaentaenoic acid and it blocks
  angiogenesis. A metabolite of arachidonic acid
  had the opposite effect.
• University of California - Davis Health System.
  "Fatty acid metabolite shows promise against
  cancer in mice." ScienceDaily. ScienceDaily, 2
  April 2013. ltwww.sciencedaily.com/releases/2013/04
  /130402143944.htmgt.

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Soy and Cancer

• Soybeans are a unique source of the isoflavone
  genistein, which possesses weak estrogenic
  activity and has been shown to act in animal
  models as an antiestrogen. Genistein is also a
  specific inhibitor of protein tyrosine kinases
  it also inhibits DNA topoisomerases and other
  critical enzymes involved in signal transduction.
  In vitro, genistein suppresses the growth of a
  wide range of cancer cells
• Protective effects were observed for both
  hormone and nonhormone-related cancers.
• Messina, Mark J., et al., Soy intake and cancer
  risk A review of the in vitro and in vivo data,
  Nutrition and Cancer, 199421(2)113-131.
• http//en.wikipedia.org/wiki/Tyrosine_kinase

Tyrosine kinases stuck in the on position
(promoting unregulated cell growth) are a
necessary step in the development of cancer.
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Lunasin
Prostate and breast cancers are 4-10 times more
common in the U.S. than in southeast Asia. Rates
become identical within one generation of moving
to the U.S. In spite of its cancer-preventative
properties, lunasin does not affect the growth
rate of normal and established cell lineslunasin
selectively kills cells being transformed or
newly transformed leading to cell death. De
Lumen, Ben O., Lunasin A Cancer-Preventive Soy
Peptide, Nutrition Reviews, January 2005
63(1)16-21.
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Lunasin
One of the properties of an ideal
cancer-preventive agent is that it can be taken
orally.Pilot studies (of lunasin) showed that
about 35 of the oral dose is absorbed and ends
up in the various tissues of mice and rats 6
hours after administration De Lumen, Ben O.,
Lunasin A Cancer-Preventive Soy Peptide,
Nutrition Reviews, January 2005 63(1)16-21.
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Phytonutrients and Cancer
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Allium Cruciferous

• As a first step towards the identification of
  foods endowed with the most potent
  chemopreventive activities, we evaluated the
  inhibitory effects of extracts isolated from 34
  vegetables on the proliferation of 8 different
  tumour cell lines. The extracts from cruciferous
  vegetables as well as those from vegetables of
  the genus Allium inhibited the proliferation of
  all tested cancer cell lines whereas extracts
  from vegetables most commonly consumed in Western
  countries were much less effective. The
  antiproliferative effect of vegetables was
  specific to cells of cancerous origin and was
  found to be largely independent of their
  antioxidant properties.

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Brain and Lung Cancer
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Prostate Pancreatic Cancer
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Brain and Kidney Cancer
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Breast and Stomach Cancer
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Two Powerful Supplements
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Parkinsons Disease
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The Detoxification Connection

• Parkinsons is more common in those with a
  history of exposure to agricultural and other
  toxic chemicals.
• There also appears to be a defect in the ability
  to detoxify these substances.
• Tanner, C.M., Liver Abnormalities in Parkinsons
  disease, Geriatrics 46 (1)60-63, 1991.
• Since the late 1980s, a steady stream of studies
  from around the world has shown again and again
  that a common thread among victims of Parkinson's
  is a history of exposure to insecticides and
  herbicides. Most recently a study showed that
  exposure to industrial solvents is linked to
  Parkinson's.
• J.M. Gorell, "The risk of Parkinson's disease
  with exposure to pesticides, farming, well water,
  and rural living," NEUROLOGY Vol. 50, No. 5 (May
  1998), pgs. 1346-1350.
• A. Smargiassi and others, "A case-control study
  of occupational and environmental risk factors
  for Parkinson's disease in the Emilia-Romagna
  region of Italy," NEUROTOXICOLOGY Vol. 19, Nos.
  4-5 (August-October 1998), pgs. 709-712.

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The Detoxification Connection

• In 1976 Barry Kidston, a 23-year-old chemistry
  student, synthesized MPPP (an opioid)
  contaminated with MPTP. He self-injected and
  began experiencing symptoms of Parkinsons 3 days
  later. Autopsy 18 months later showed destruction
  of the substantia nigra (part of the brain).
• http//en.wikipedia.org/wiki/MPTP
• In the 1980s a recreational drug (meperidine)
  similar in chemical structure to several
  pesticides and herbicides was shown to cause
  symptoms of Parkinsons in young people.
• J.W. Langston and others, "Chronic Parkinsonism
  in humans due to a product of meperidine-analog
  synthesis," SCIENCE Vol. 219, No. 4587 (February
  25, 1983), pgs. 979-980.

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Folic Acid Protects

• National Institute on Aging (NIA) Study
• Mice on a low intake of folic acid had an 8-fold
  increase in homocysteine
• Exposure to MPTP, a chemical that causes
  Parkinsons created symptoms of the disease in
  deficient mice.
• Mice on a diet with adequate folic acid were
  resistant to the chemical.
• Folic acid protects adult nerve cells from age
  related disease.
• Injection of homocysteine directly into the brain
  increased symptoms dramatically.
• Folic acid deficiency by itself did not cause
  Parkinsons-like problems.

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Abstract January 2002

• The ability of folate deficiency and elevated
  homocysteine levels to sensitize dopaminergic
  neurons to environmental toxins suggests a
  mechanism whereby dietary folate may influence
  risk for PD.
• Wenzhen Duan, Bruce Ladenheim , Roy G. Cutler,
  Inna I. Kruman, Jean Lud Cadet and Mark P.
  Mattson, Dietary folate deficiency and elevated
  homocysteine levels endanger dopaminergic neurons
  in models of Parkinson's disease, Journal of
  Neurochemistry, Vol. 80, No. 1, January 2002
  101-110

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Riboflavin

• Researchers in Brazil found that 31 Parkinsons
  patients they tested were deficient in riboflavin
  (vitamin B2). Supplementation of 19 of these for
  6 months with 30 milligrams of vitamin B2 3 times
  a day improved functional motor capacity from 44
  of normal to 71 of normal. Patients were also
  instructed to discontinue eating red meat, which
  releases hemin, a potential neurotoxin, during
  the process of digestion.
• Coimbra, C. G., et al, High doses of riboflavin
  and the elimination of dietary red meat promote
  the recovery of some motor functions in
  Parkinsons disease patients, Braziliean Journal
  of Medical and Biological Research, 2003
  36(10)1409-1417.

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Key Supplements for Prevention of Parkinsons
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Prostate Problems
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Prostatic Hyperplasia
Definitions Hyperplasia-increase in the number
of cells. Hypertrophy-increase in the size of the
cells.
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BPH Benign Prostatic Hyperplasia

• 10 of men in their 20s and 30s
• 50 of men under 60.
• 90 of men over 80
• Prostrate surgery is the 2nd most common surgery
  in America after cataract surgery.
• Firshein, Richard, The Nutraceutical Revolution,
  New York Penguin Putnam, 1998, 299-302.

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Nature of the Problem

• The prostate surrounds the first inch of the
  urethra, the thin tube that carries the urine to
  the bladder.
• The prostate often becomes enlarged or swollen as
  men age. Symptoms frequent urination, urinary
  frequency, burning while urinating, dribbling.
• http//commons.wikimedia.org/wiki/FileHypertrophy
  _of_the_inter-uretal_fold_of_a_bladder_Wellcome_L0
  061771.jpg
• Complications
• Kidney damage
• Kidney stones
• Urinary retention
• Insomnia

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Causes of BPH

• BPH is associated with metabolic syndrome. The
  findings generate a hypothesis of a causal
  relationship between high insulin levels and the
  development of BPH.
• Associated factors diabetes, obesity, high
  insulin, low HDL levels.
• Hammarsten, J., et al., Components of the
  metabolic syndrome-risk factors for the
  development of benign prostatic hyperplasia,
  Prostate Cancer and Prostatic Diseases,
  19981(3)157-162.

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Causes of BPH Bisphenol A

• Bisphenol A (an estrogenic plastic ingredient) at
  low doses induced the prostate of rats to
  proliferate and aggravated testosterone-induced
  benign hyperplasia.
• Adverse effects of low-dose estrogenic chemicals
  (bisphenol A, octylphenol, diethylstilbestrol)
  include oviduct rupture, an enlarged prostate,
  feminization of males and reduced sperm quality.
• Wu, Jian-Hui, et al., Oral exposure to low-dose
  bisphenol A aggravates testosterone-induced
  benign hyperplasia prostate in rats, Toxicology
  and Industrial Health, October 2011
  27(9)810-819.
• Weltje, Lennart, et al., Reproductive stimulation
  by low doses of xenoestrogens contrasts with the
  view of hormesis as an adaptive response, Human
  and Experimental Toxicology, 200524431-437.

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Causes of BPH

• BPA increases the estradiol/testosterone ratio
  and aromatase. Aromatase is a key enzyme involved
  in estrogen synthesis.
• Castro B, Sánchez P, Torres JM, Preda O, del
  Moral RG, et al. (2013) Bisphenol A Exposure
  during Adulthood Alters Expression of Aromatase
  and 5a-Reductase Isozymes in Rat Prostate. PLoS
  ONE 8(2) e55905. doi10.1371/journal.pone.0055905

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Causes of BPHDHT

• Persistent bacterial infection.
• Transformation of testosterone to DHT
  (dihydrotestosterone) by other hormones (that
  rise as men age. The enzyme 5-alpha-reductase
  converts testosterone to DHT. DHT is 10 times
  stronger than testosterone because it clings to
  the androgen receptor longer.
• Castrated boys do not develop BPH.

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Medical Treatments

• Drugs
• a-adrenergic blocking agents or alpha blockers.
  These drugs are muscle relaxants (terazosin,
  alfuzosin, tamsulosin, silodosin)
• 5 a-reductase inhibitors block DHT formation.
  Finasteride dutasteride, are pharmaceutical to
  treatments for BPH.
• Aromatase inhibitors Block production of
  estrogen. (Atamestane)

• Surgery
• TURP trans-urethral resection of the prostate
  (2nd most common surgery in America). Involves
  boring a hole through the enlarged prostate.
• Prostatectomy Removal of the prostate.

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Natural 5-alpha Reductase Inhibitors

• St. Johns wort
• GLA
• Alpha-linolenic acid (flax oil)
• MCT (coconut oil)
• Peppermint
• Sage
• Hops
• Genistein and daidzein (soy)
• Resveratrol
• https//en.wikipedia.org/wiki/5-alpha-reductase_in
  hibitor

• Zinc
• Vitamin B2
• Beta-sitosterol
• Polyphenols
• Curcumin
• Green tea catechins
• Chinese Knotweed
• Saw Palmetto (Dual inhibition activity)
• Reishi mushroom

• Supplements
• Zinc
• B Complex
• Tre-en-en
• Tre
• Flavonoid Complex
• Masculine Herbal
• NeoLife Shake (soy)

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Natural inhibitors of Aromatase

• Zinc
• Vitamin E
• Catechin
• Chalcones
• Apigenin
• Eriodictyol
• Isoliquiritigenin
• Mangostin
• Myosmine
• Nicotine
• Resveratrol
• https//en.wikipedia.org/wiki/Aromatase

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Exercise and BPH

• There is a strong inverse relationship between
  exercise and the development of BPH and lower
  urinary tract symptoms.
• Sea, J., et al., Review of exercise and the risk
  of benign prostatic hyperplasia, The Physician
  and Sportsmedicine, 200937(4)75-83.

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Backward Pressure on Venous System

• We found that in all BPH patients, the one-way
  valves in thespermatic veins are
  destroyedcausing elevated hydrostatic pressure,
  some 6-fold greater than normalwe found that
  free testosterone levels in this blood are
  markedly elevated, with a concentration of some
  130-fold above serum level.
• The pressure causes prostate cells to swell and
  the testosterone causes the number of cells to
  increase. Elimination of the back pressure caused
  rapid regression of symptoms.

Gat, Y., et al., Reversal of benign prostate
hyperplasia by selective occlusion of impaired
venous drainage in the male reproductive system
novel mechanism, new treatment, Andrologia,
200840273-281.
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Back Pressure on Venous System

• Destruction of the one way valves in the veins
  reaches 75 at the age of 70.

Impaired venous flow here builds pressure and
hormone levels in prostate tissue. Aggravated by
lack of exercise, weight gain, and weak
connective tissue.
Prostate
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Home Treatment Tips

• Practice double voiding
• Avoid caffeine and alcohol which increase
  urination
• Antihistamines, decongestants, and allergy pills
  make urination difficult.

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Migraine
60
Migraine

• 12 of 21 children with migraine and bedwetting
  problems improved on an elimination diet. 8
  relapsed after reintroduction of the offending
  foods.
• Egger, J., M.D., et al, "Effect of Diet Treatment
  on Enuresis in Children With Migraine or
  Hyperkinetic Behavior", Clinical Pediatrics, May
  1992302-307.
• 50 of migraine sufferers improved with
  elimination of specific foods although prick
  tests and blood IgE levels were normal.
• Nattero, Giovanni, et al, "Dietary Migraine as
  Adverse Reactions", Cephalalgia, 1989
  9(10)193-194.

• Candida albicans overgrowth. Garlic and
  acidophilus suppress.
• Heuser, Gunnar, M.D., Ph.D., et al, "Candida
  Albicans and Migraine Headaches A Possible
  Link", Journal of the Advancement in Medicine,
  Fall 19925(3)177-187.
• Melatonin supplementation reduced frequency.
• Peres MFP, Zukerman E, et al, "Melatonin, 3 mg,
  Is Effective for Migraine Prevention," Neurology,
  August 200463(2 of 2)757. 

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Sleep Quality and Melatonin

• Ear plugs and eye masks significantly elevated
  melatonin in the intensive care unit (ICU).
  Melatonin is a simple derivative of tryptophan.
• "Melatonin Hormone of Darkness", Editorial,
  British Medical Journal, 1993307.

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Migraine and Mitochondrial Energy

• Red blood cell magnesium levels are low in
  migraine sufferers. Supplementation produces
  benefits.
• Gallai, Virgilio, et al, "Red Blood Cell
  Magnesium Levels in Migraine Patients",
  Cephalalgia, 19931394-98.
• 49 patients with migraine were given 400 mg B2
  before breakfast for 3 months. Headache scores
  improved by 68.
• Schoenen, J., et al., High-dose riboflavin as a
  prophylactic treatment of migraine Results of an
  open pilot study, Cephalalgia , October 1994 
  14(5)328-329

• Case report of 2 individuals who were able to
  relieve migraine pain by taking 500 mg of niacin.
• Prousky JE, Sykes E, "Two Case Reports on the
  Treatment of Acute Migraine With Niacin Its
  Hypothetical Mechanism of Action Upon
  Calcitonin-Gene Related Peptide and Platelets," J
  Orthomol Med, 200318(2)108-110.
• About 75 of young migraine sufferers were
  deficient in CoQ10. Supplementation reduced
  frequency and severity.
• Hershey AD, Powers SW, et al, "Coenzyme Q10
  Deficiency and Response to Supplementation in
  Pediatric and Adolescent Migraine," Headache,
  2007 47(1) 73-80.

63
Migraine

• Scientists from the Genomics Research Centre
  (GRC) at Griffith University in Brisbane
  investigated giving 52 migraine sufferers
  supplements that lower homocysteine (B6 25 mg,
  B12 400 mcg and folic acid 2 mg). These
  levels are at least 10X RDA levels. Homocysteine
  levels were reduced by 39. Reduction in migraine
  disability went from 60 at the start of the
  study to 30 after 6 months.
• Lea, Rod, et al., The effects of supplementation
  and MTHFR (C677T) genotype on homocysteine-lowerin
  g and migraine disability, Pharmacogenetics and
  Genomics, June 2009 19(6)422-428.
• Other supplements involved in methylation TMG
  (betaine), zinc, vitamin B2)

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The End